Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Ppp2r2d (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PPP2R2D mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PPP2R2D mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPP2R2D mRNA | CTD | PMID:33387578 | 2,6-dinitrotoluene | affects expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of PPP2R2D mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PPP2R2D mRNA | CTD | PMID:19285098 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of PPP2R2D gene | CTD | PMID:31601247 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of PPP2R2D gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of PPP2R2D mRNA | CTD | PMID:23724009 | ammonium chloride | affects expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of PPP2R2D mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of PPP2R2D mRNA | CTD | PMID:24449571 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of PPP2R2D 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PPP2R2D mRNA | CTD | PMID:25181051 more ... | bisphenol A | affects splicing | ISO | Ppp2r2d (Mus musculus) | 6480464 | bisphenol A affects the splicing of PPP2R2D mRNA | CTD | PMID:37894381 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PPP2R2D gene] | CTD | PMID:28238834 | ciguatoxin CTX1B | affects expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Ciguatoxins affects the expression of PPP2R2D mRNA | CTD | PMID:18353800 | clofibrate | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Clofibrate results in increased expression of PPP2R2D mRNA | CTD | PMID:23811191 | copper atom | multiple interactions | EXP | | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of PPP2R2D mRNA and [NSC 689534 binds to Copper] which results in increased expression of PPP2R2D mRNA | CTD | PMID:20971185 and PMID:30911355 | copper(0) | multiple interactions | EXP | | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of PPP2R2D mRNA and [NSC 689534 binds to Copper] which results in increased expression of PPP2R2D mRNA | CTD | PMID:20971185 and PMID:30911355 | crocidolite asbestos | decreases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PPP2R2D mRNA | CTD | PMID:29279043 | decabromodiphenyl ether | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in increased expression of PPP2R2D mRNA | CTD | PMID:23640034 | dichloroacetic acid | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of PPP2R2D mRNA | CTD | PMID:28962523 | disodium selenite | increases expression | EXP | | 6480464 | Sodium Selenite results in increased expression of PPP2R2D mRNA | CTD | PMID:18175754 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2D mRNA | CTD | PMID:27188386 | entinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2D mRNA | CTD | PMID:27188386 | ethanol | affects expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Ethanol affects the expression of PPP2R2D mRNA | CTD | PMID:30319688 | fenthion | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Fenthion results in increased expression of PPP2R2D mRNA | CTD | PMID:34813904 | finasteride | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of PPP2R2D mRNA | CTD | PMID:24136188 | flavonoids | decreases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Flavonoids results in decreased expression of PPP2R2D mRNA | CTD | PMID:18035473 | folic acid | multiple interactions | ISO | Ppp2r2d (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PPP2R2D mRNA | CTD | PMID:22206623 | gentamycin | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PPP2R2D mRNA | CTD | PMID:22061828 and PMID:33387578 | methidathion | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | methidathion results in increased expression of PPP2R2D mRNA | CTD | PMID:34813904 | methyl methanesulfonate | increases expression | EXP | | 6480464 | Methyl Methanesulfonate results in increased expression of PPP2R2D mRNA | CTD | PMID:23649840 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | decreases expression | EXP | | 6480464 | N more ... | CTD | PMID:12756304 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of PPP2R2D gene | CTD | PMID:33148267 | nefazodone | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of PPP2R2D mRNA | CTD | PMID:24136188 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PPP2R2D mRNA | CTD | PMID:35430440 | paracetamol | affects expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Acetaminophen affects the expression of PPP2R2D mRNA | CTD | PMID:17562736 | permethrin | multiple interactions | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of PPP2R2D gene | CTD | PMID:33148267 | pirinixic acid | multiple interactions | ISO | Ppp2r2d (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPP2R2D mRNA and [pirinixic acid co-treated with PPARA] results in increased expression of PPP2R2D mRNA | CTD | PMID:19710929 and PMID:20813756 | pirinixic acid | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PPP2R2D mRNA | CTD | PMID:17426115 more ... | quercetin | increases expression | EXP | | 6480464 | Quercetin results in increased expression of PPP2R2D mRNA | CTD | PMID:30152185 | resveratrol | multiple interactions | EXP | | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PPP2R2D mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2D mRNA | CTD | PMID:27188386 | tetrachloroethene | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of PPP2R2D mRNA | CTD | PMID:28973375 | thapsigargin | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Thapsigargin results in increased expression of PPP2R2D protein | CTD | PMID:35544339 | thioacetamide | increases expression | ISO | Ppp2r2d (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of PPP2R2D mRNA | CTD | PMID:23411599 and PMID:34492290 | trichloroethene | increases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of PPP2R2D mRNA | CTD | PMID:28973375 | triptonide | decreases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | triptonide results in decreased expression of PPP2R2D mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of PPP2R2D gene | CTD | PMID:29154799 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of PPP2R2D mRNA | CTD | PMID:19101580 | valproic acid | affects expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Valproic Acid affects the expression of PPP2R2D mRNA | CTD | PMID:17292431 | valproic acid | decreases expression | ISO | Ppp2r2d (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of PPP2R2D mRNA | CTD | PMID:17963808 and PMID:21427059 | vorinostat | decreases expression | EXP | | 6480464 | vorinostat results in decreased expression of PPP2R2D mRNA | CTD | PMID:27188386 | zinc sulfate | increases expression | EXP | | 6480464 | Zinc Sulfate results in increased expression of PPP2R2D mRNA | CTD | PMID:12756304 | 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