HCAR3 (hydroxycarboxylic acid receptor 3)

Gene: HCAR3 (hydroxycarboxylic acid receptor 3) Homo sapiens

Analyze

Symbol:

HCAR3

Name:

hydroxycarboxylic acid receptor 3

RGD ID:

1348987

HGNC Page

HGNC:16824

Description:

Predicted to enable GTP binding activity; nicotinic acid receptor activity; and purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cell junction.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GPR109B; GTP-binding protein; HCA3; HM74; hydroxy-carboxylic acid receptor 3; niacin receptor 2; nicotinic acid receptor 2; Puma-g; PUMAG; putative chemokine receptor

RGD Orthologs

Mouse

Bonobo

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Hcar2 (hydroxycarboxylic acid receptor 2)	HGNC	EggNOG, Ensembl, HGNC, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100986398 (hydroxycarboxylic acid receptor 3)	NCBI	Ortholog
Other homologs ²
Sus scrofa (pig):	HCAR2 (hydroxycarboxylic acid receptor 2)	HGNC	Ensembl, OMA, OrthoDB, Panther
Rattus norvegicus (Norway rat):	Fcmr (Fc mu receptor)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Hcar2 (hydroxycarboxylic acid receptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hcar2 (hydroxycarboxylic acid receptor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hcar1-3 (hydroxycarboxylic acid receptor 1-3)	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus laevis (African clawed frog):	hcar3.L	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	hcar3.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	122,714,756 - 122,716,811 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	122,714,756 - 122,716,811 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	123,199,303 - 123,201,358 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	121,765,256 - 121,767,392 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	121,724,182 - 121,726,224	NCBI
Celera	12	122,778,682 - 122,780,822 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	120,159,744 - 120,161,468 (-)	NCBI		HuRef
CHM1_1	12	123,167,514 - 123,169,650 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	122,710,140 - 122,712,195 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

essential hypertension (EXP)

genetic disease (IAGP)

Skin Neoplasms (EXP)

squamous cell carcinoma (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (EXP)

3',5'-cyclic AMP (EXP)

3,4-dichloroaniline (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (EXP)

avobenzone (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP)

bisphenol F (EXP)

calcitriol (EXP)

calcium atom (EXP)

calcium(0) (EXP)

ciglitazone (EXP)

copper(II) sulfate (EXP)

crocidolite asbestos (EXP)

cyclosporin A (EXP)

dioxygen (EXP)

diuron (EXP)

ethyl methanesulfonate (EXP)

fonofos (EXP)

irinotecan (EXP)

lipopolysaccharide (EXP)

methyl methanesulfonate (EXP)

nickel atom (EXP)

nicotinic acid (EXP)

paracetamol (EXP)

parathion (EXP)

progesterone (EXP)

pyrazoles (EXP)

rac-lactic acid (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

silicon dioxide (EXP)

terbufos (EXP)

triazoles (EXP)

urethane (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA,IEA,TAS)

signal transduction (IEA)

Cellular Component

cell junction (IDA)

membrane (IEA,ISO)

plasma membrane (IBA,IEA,TAS)

Molecular Function

G protein-coupled receptor activity (IEA,TAS)

GTP binding (ISO)

nicotinic acid receptor activity (IBA,IEA)

purinergic nucleotide receptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7505609	PMID:9205127	PMID:12090300	PMID:12477932	PMID:12522134	PMID:12563315	PMID:12646212	PMID:15489334	PMID:16344560	PMID:17562024	PMID:18983141	PMID:19237584
PMID:19460752	PMID:19502010	PMID:19561068	PMID:19633298	PMID:19913121	PMID:20380810	PMID:20628086	PMID:21454438	PMID:21655214	PMID:21873635	PMID:22289163	PMID:25839160
PMID:26656756	PMID:32102673	PMID:34852802	PMID:34948292	PMID:34968686

Genomics

Comparative Map Data

HCAR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	122,714,756 - 122,716,811 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	122,714,756 - 122,716,811 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	123,199,303 - 123,201,358 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	121,765,256 - 121,767,392 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	121,724,182 - 121,726,224	NCBI
Celera	12	122,778,682 - 122,780,822 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	120,159,744 - 120,161,468 (-)	NCBI		HuRef
CHM1_1	12	123,167,514 - 123,169,650 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	122,710,140 - 122,712,195 (-)	NCBI		T2T-CHM13v2.0

Hcar2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	124,001,633 - 124,003,579 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	124,001,633 - 124,003,562 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	123,863,570 - 123,865,516 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	123,863,570 - 123,865,499 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	124,313,581 - 124,315,518 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	124,124,193 - 124,126,114 (-)	NCBI		MGSCv36	mm8
Celera	5	120,935,826 - 120,937,763 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	63.24	NCBI

LOC100986398
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	130,808,252 - 130,814,753 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	130,804,391 - 130,811,129 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	120,318,905 - 120,322,068 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	124,553,121 - 124,555,252 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	124,553,940 - 124,555,103 (-)	Ensembl	panpan1.1		panPan2

Variants

Variants in HCAR3
20 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 12q24.23-24.33(chr12:118165459-133182322)x3	copy number gain	See cases [RCV000050866]	Chr12:118165459..133182322 [GRCh38] Chr12:118603264..133758908 [GRCh37] Chr12:117087647..132268981 [NCBI36] Chr12:12q24.23-24.33	pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:115131583-133166920)x3	copy number gain	See cases [RCV000053689]	Chr12:115131583..133166920 [GRCh38] Chr12:115569388..133743506 [GRCh37] Chr12:114053771..132253579 [NCBI36] Chr12:12q24.21-24.33	pathogenic
GRCh38/hg38 12q24.23-24.33(chr12:119417382-133191400)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053691]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053691]\|See cases [RCV000053691]	Chr12:119417382..133191400 [GRCh38] Chr12:119855187..133767986 [GRCh37] Chr12:118339570..132278059 [NCBI36] Chr12:12q24.23-24.33	pathogenic
NM_006018.2(HCAR3):c.150G>A (p.Trp50Ter)	single nucleotide variant	Malignant melanoma [RCV000069868]	Chr12:122716588 [GRCh38] Chr12:123201135 [GRCh37] Chr12:121767088 [NCBI36] Chr12:12q24.31	not provided
NM_006018.2(HCAR3):c.296C>T (p.Pro99Leu)	single nucleotide variant	Malignant melanoma [RCV000062429]	Chr12:122716442 [GRCh38] Chr12:123200989 [GRCh37] Chr12:121766942 [NCBI36] Chr12:12q24.31	not provided
GRCh38/hg38 12q24.31-24.33(chr12:120697672-133202490)x3	copy number gain	See cases [RCV000137651]	Chr12:120697672..133202490 [GRCh38] Chr12:121135475..133779076 [GRCh37] Chr12:119619858..132289149 [NCBI36] Chr12:12q24.31-24.33	pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3	copy number gain	See cases [RCV000139555]	Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33	pathogenic
GRCh38/hg38 12q24.31(chr12:122646987-123057419)x3	copy number gain	See cases [RCV000141434]	Chr12:122646987..123057419 [GRCh38] Chr12:123131534..123541966 [GRCh37] Chr12:121697487..122107919 [NCBI36] Chr12:12q24.31	uncertain significance
GRCh38/hg38 12q24.31-24.32(chr12:120718786-127500215)x1	copy number loss	See cases [RCV000142454]	Chr12:120718786..127500215 [GRCh38] Chr12:121156589..127984760 [GRCh37] Chr12:119640972..126550713 [NCBI36] Chr12:12q24.31-24.32	pathogenic
GRCh38/hg38 12q24.31-24.32(chr12:121917758-127802717)x1	copy number loss	See cases [RCV000143250]	Chr12:121917758..127802717 [GRCh38] Chr12:122355664..128287262 [GRCh37] Chr12:120840047..126853215 [NCBI36] Chr12:12q24.31-24.32	pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:114268403-133201316)x3	copy number gain	See cases [RCV000143656]	Chr12:114268403..133201316 [GRCh38] Chr12:114706208..133777902 [GRCh37] Chr12:113190591..132287975 [NCBI36] Chr12:12q24.21-24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3	copy number gain	See cases [RCV000258805]	Chr12:1..133851895 [GRCh37] Chr12:12p13.33-q24.33	pathogenic\|likely pathogenic
GRCh37/hg19 12q24.31-24.32(chr12:122726807-127365912)x1	copy number loss	See cases [RCV000449178]	Chr12:122726807..127365912 [GRCh37] Chr12:12q24.31-24.32	likely pathogenic
GRCh37/hg19 12q24.31(chr12:123185916-123199400)x3	copy number gain	See cases [RCV000446957]	Chr12:123185916..123199400 [GRCh37] Chr12:12q24.31	conflicting data from submitters
GRCh37/hg19 12q24.31(chr12:122938957-123747037)x3	copy number gain	See cases [RCV000447635]	Chr12:122938957..123747037 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12q24.31(chr12:123185916-123200173)x3	copy number gain	See cases [RCV000447922]	Chr12:123185916..123200173 [GRCh37] Chr12:12q24.31	benign
GRCh37/hg19 12q24.31(chr12:123185916-123200755)x3	copy number gain	See cases [RCV000448431]	Chr12:123185916..123200755 [GRCh37] Chr12:12q24.31	benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3	copy number gain	See cases [RCV000510482]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)	copy number gain	See cases [RCV000511643]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12q24.23-24.33(chr12:120367241-133777645)x3	copy number gain	not provided [RCV000738070]	Chr12:120367241..133777645 [GRCh37] Chr12:12q24.23-24.33	pathogenic
GRCh37/hg19 12q24.31(chr12:122706844-124294517)x3	copy number gain	not provided [RCV000738079]	Chr12:122706844..124294517 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3	copy number gain	not provided [RCV000750246]	Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3	copy number gain	not provided [RCV000750253]	Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12q24.31-24.32(chr12:122169403-129084163)x1	copy number loss	not provided [RCV000848395]	Chr12:122169403..129084163 [GRCh37] Chr12:12q24.31-24.32	pathogenic
NM_006018.3(HCAR3):c.647G>A (p.Arg216Gln)	single nucleotide variant	Inborn genetic diseases [RCV003251910]	Chr12:122716091 [GRCh38] Chr12:123200638 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12q24.31(chr12:122737779-123265478)x3	copy number gain	not provided [RCV002472674]	Chr12:122737779..123265478 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12q24.22-24.33(chr12:117461902-133841395)x3	copy number gain	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures [RCV001801213]	Chr12:117461902..133841395 [GRCh37] Chr12:12q24.22-24.33	likely pathogenic
GRCh37/hg19 12q24.31(chr12:121887337-123386068)x3	copy number gain	not provided [RCV001795860]	Chr12:121887337..123386068 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12q24.31(chr12:122938957-123747037)	copy number gain	not specified [RCV002053031]	Chr12:122938957..123747037 [GRCh37] Chr12:12q24.31	uncertain significance
NC_000012.11:g.(?_122277634)_(124242579_?)del	deletion	not provided [RCV003111519]	Chr12:122277634..124242579 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.507C>G (p.Ile169Met)	single nucleotide variant	Inborn genetic diseases [RCV002682123]	Chr12:122716231 [GRCh38] Chr12:123200778 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.985G>A (p.Val329Ile)	single nucleotide variant	Inborn genetic diseases [RCV002992705]	Chr12:122715753 [GRCh38] Chr12:123200300 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.1021G>A (p.Ala341Thr)	single nucleotide variant	Inborn genetic diseases [RCV002772590]	Chr12:122715717 [GRCh38] Chr12:123200264 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.65G>A (p.Arg22Gln)	single nucleotide variant	Inborn genetic diseases [RCV002794658]	Chr12:122716673 [GRCh38] Chr12:123201220 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.229A>G (p.Ile77Val)	single nucleotide variant	Inborn genetic diseases [RCV002849292]	Chr12:122716509 [GRCh38] Chr12:123201056 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.551A>G (p.His184Arg)	single nucleotide variant	Inborn genetic diseases [RCV002950534]	Chr12:122716187 [GRCh38] Chr12:123200734 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.775C>T (p.His259Tyr)	single nucleotide variant	Inborn genetic diseases [RCV002694753]	Chr12:122715963 [GRCh38] Chr12:123200510 [GRCh37] Chr12:12q24.31	likely benign
NM_006018.3(HCAR3):c.466G>C (p.Val156Leu)	single nucleotide variant	Inborn genetic diseases [RCV002759856]	Chr12:122716272 [GRCh38] Chr12:123200819 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.808C>T (p.Arg270Cys)	single nucleotide variant	Inborn genetic diseases [RCV002799494]	Chr12:122715930 [GRCh38] Chr12:123200477 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.991C>T (p.Leu331Phe)	single nucleotide variant	Inborn genetic diseases [RCV002893464]	Chr12:122715747 [GRCh38] Chr12:123200294 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.307G>A (p.Val103Met)	single nucleotide variant	Inborn genetic diseases [RCV002920739]	Chr12:122716431 [GRCh38] Chr12:123200978 [GRCh37] Chr12:12q24.31	likely benign
NM_006018.3(HCAR3):c.383G>A (p.Arg128Gln)	single nucleotide variant	Inborn genetic diseases [RCV003220355]	Chr12:122716355 [GRCh38] Chr12:123200902 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.1057T>C (p.Trp353Arg)	single nucleotide variant	Inborn genetic diseases [RCV003219900]	Chr12:122715681 [GRCh38] Chr12:123200228 [GRCh37] Chr12:12q24.31	uncertain significance
NM_006018.3(HCAR3):c.752G>A (p.Arg251Gln)	single nucleotide variant	Inborn genetic diseases [RCV003172878]	Chr12:122715986 [GRCh38] Chr12:123200533 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12q24.31(chr12:121341598-124103434)x3	copy number gain	See cases [RCV003329531]	Chr12:121341598..124103434 [GRCh37] Chr12:12q24.31	uncertain significance
GRCh37/hg19 12q24.31-24.33(chr12:121551496-133777902)x3	copy number gain	not provided [RCV003484881]	Chr12:121551496..133777902 [GRCh37] Chr12:12q24.31-24.33	pathogenic
GRCh37/hg19 12q24.31-24.33(chr12:120880079-133777902)x3	copy number gain	not provided [RCV003484880]	Chr12:120880079..133777902 [GRCh37] Chr12:12q24.31-24.33	pathogenic
NM_006018.3(HCAR3):c.981G>A (p.Thr327=)	single nucleotide variant	not provided [RCV003392168]	Chr12:122715757 [GRCh38] Chr12:123200304 [GRCh37] Chr12:12q24.31	likely benign

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	295
Count of miRNA genes:	252
Interacting mature miRNAs:	266
Transcripts:	ENST00000528880
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

D12S2030

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	123,199,430 - 123,199,769	UniSTS	GRCh37
Build 36	12	121,765,383 - 121,765,722	RGD	NCBI36
Cytogenetic Map	12	q24.31	UniSTS
GeneMap99-GB4 RH Map	12	475.07	UniSTS
Whitehead-RH Map	12	591.3	UniSTS
Whitehead-YAC Contig Map	12		UniSTS
NCBI RH Map	12	779.6	UniSTS

GC10S02

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	123,199,949 - 123,201,032	UniSTS	GRCh37
Build 36	12	121,765,902 - 121,766,985	RGD	NCBI36
Celera	12	122,792,753 - 122,793,838	UniSTS
Celera	12	122,779,330 - 122,780,415	RGD
Cytogenetic Map	12	q24.31	UniSTS
HuRef	12	120,159,978 - 120,161,061	UniSTS

GPR109B_8864

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	123,199,243 - 123,199,999	UniSTS	GRCh37
GRCh37	12	123,185,780 - 123,186,540	UniSTS	GRCh37
Build 36	12	121,751,733 - 121,752,493	RGD	NCBI36
Celera	12	122,792,045 - 122,792,805	UniSTS
Celera	12	122,778,622 - 122,779,382	RGD
HuRef	12	120,159,551 - 120,160,028	UniSTS
HuRef	12	120,146,139 - 120,146,899	UniSTS

RH17364

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	123,199,508 - 123,199,743	UniSTS	GRCh37
GRCh37	12	123,186,047 - 123,186,282	UniSTS	GRCh37
Build 36	12	121,752,000 - 121,752,235	RGD	NCBI36
Celera	12	122,792,312 - 122,792,547	UniSTS
Celera	12	122,778,889 - 122,779,124	RGD
Cytogenetic Map	12	q24.31	UniSTS
HuRef	12	120,146,406 - 120,146,641	UniSTS
GeneMap99-GB4 RH Map	12	475.07	UniSTS
NCBI RH Map	12	779.6	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

703

839

534

148

250

Low

246

421

506

303

536

189

1540

112

247

137

478

815

121

1075

631

Below cutoff

1266

1178

940

253

338

215

1244

1050

2221

194

685

483

102

1113

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_006018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB065865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC026333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK290930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK313212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC038955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC047891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI908162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB529340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD366840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU451507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D10923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA948030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA953971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU293604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU285448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	R02740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000528880 ⟹ ENSP00000436714

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	122,714,756 - 122,716,811 (-)	Ensembl

RefSeq Acc Id:

NM_006018 ⟹ NP_006009

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	122,714,756 - 122,716,811 (-)	NCBI
GRCh37	12	123,199,303 - 123,201,439 (-)	ENTREZGENE
Build 36	12	121,765,256 - 121,767,392 (-)	NCBI Archive
HuRef	12	120,159,744 - 120,161,468 (-)	ENTREZGENE
CHM1_1	12	123,167,514 - 123,169,650 (-)	NCBI
T2T-CHM13v2.0	12	122,710,140 - 122,712,195 (-)	NCBI

Sequence:

show sequence

ACCATACAGACACACGCCACTTTGCTGGAGCATTCACTAGGCGAGGCGCTCCATCGGACTCACT
AGCTGCACTCATGAATCGGCACCATCTGCAGGATCACTTTCTGGAAATAGACAAGAAGAACTGC
TGTGTGTTCCGAGATGACTTCATTGCCAAGGTGTTGCCGCCGGTGTTGGGGCTGGAGTTTATCT
TTGGGCTTCTGGGCAATGGCCTTGCCCTGTGGATTTTCTGTTTCCACCTCAAGTCCTGGAAATC
CAGCCGGATTTTCCTGTTCAACCTGGCAGTAGCTGACTTTCTACTGATCATCTGCCTGCCGTTC
GTGATGGACTACTATGTGCGGCGTTCAGACTGGAAGTTTGGGGACATCCCTTGCCGGCTGGTGC
TCTTCATGTTTGCCATGAACCGCCAGGGCAGCATCATATTCCTCACGGTGGTGGCGGTAGACAG
GTATTTCCGGGTGGTCCATCCCCACCACGCCCTGAACAAGATCTCCAATTGGACAGCAGCCATC
ATCTCTTGCCTTCTGTGGGGCATCACTGTTGGCCTAACAGTCCACCTCCTGAAGAAGAAGTTGC
TGATCCAGAATGGCACTGCAAATGTGTGCATCAGCTTCAGCATCTGCCATACCTTCCGGTGGCA
CGAAGCTATGTTCCTCCTGGAGTTCTTCCTGCCCCTGGGCATCATCCTGTTCTGCTCAGCCAGA
ATTATCTGGAGCCTGCGGCAGAGACAAATGGACCGGCATGCCAAGATCAAGAGAGCCATCACCT
TCATCATGGTGGTGGCCATCGTCTTTGTCATCTGCTTCCTTCCCAGCGTGGTTGTGCGGATCCA
CATCTTCTGGCTCCTGCACACTTCGGGCACGCAGAATTGTGAAGTGTACCGCTCGGTGGACCTG
GCGTTCTTTATCACTCTCAGCTTCACCTACATGAACAGCATGCTGGACCCCGTGGTGTACTACT
TCTCCAGCCCATCCTTTCCCAACTTCTTCTCCACTTTGATCAACCGCTGCCTCCAGAGGAAGAT
AACAGGTGAGCCAGATAATAACCGCAGCACGAGCGTCGAGCTCACAGGGGACCCCAACAAAACC
AGAGGCGCTCCAGAGGCGTTAATCGCCAACTCCGGTGAGCCATGGAGCCCCTCTTATCTGGGCC
CAACCTCAAATAACCATTCCAAGAAGGGACATTGTCACCAAGAACCAGCATCTCTGGAGAAACA
GTTGGGCTGTTGCATCGAGTAATGTCACTGGACTCGGCCTAAGATTTCCTGGAACTTCCAGATT
CAGAGAATCTGATTTAGGGAAACTGTGGCAGATGAGTGGGAGACTGGTTGCAAGGTGTGACCGC
AGGAATCCTGGAGGAACAGAGAGTAAAGCTTCTAGGCATCTGAAACTTGCTTCATCTCTGACGC
TCGCAGGACTGAAGATGGGCAAATTGTAGGCGTTTCTGCTGAGCAGAGTTGGAGCCAGAGATCT
ACTTGTGACTTGTTGGCCTTCTTCCCACATCTGCCTCAGACTGGAGGGGGCTCAGCTCCTGGGG
TGATATCTAGCCTGCTTGTGAGCTCTAGCAGGGATAAGGAGAGCTGAGATTGGAGGGAATTGTG
TTGTTCCTGGAGGAAGCCCAGGCATCATTAAACAAGCCAGTAGGTCACCTGGCTTCCGTGGACC
AATTCATCTTTCAGACAATCTTTAGCAGAAATGGACTCAGGGAAGAGACTCACATGCTTTGGTT
AGTATCTGTGTTTCCGGTGGGTGTAATAGGGGATTAGCCCCAGAAGGGACTGAGCTAAACAGTG
TTATTATGGGAAAGGAAATGGCATTGCTGCTTTCAACCAGCGACTAATGCAATCCATTCCTCTC
TTGTTTATAGTAATCTAAGGGTTGAACAGTTAAAACGGCTTCAGGATAGAAAGCTGTTTCCCAC
CTGTTTGCTTTTACCATTAAAAGGGAAACGTGCCTCTGCCCCACGGGTAGAGGGGTGCACGTTC
CTCCTGGTTCCTTCGCTTGTGTTTCTGTACTTACCAAAAATCTACCATTTCAATAAATTTTGAT
AGGAGACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_006009	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH47891	(Get FASTA)	NCBI Sequence Viewer
	ABX64359	(Get FASTA)	NCBI Sequence Viewer
	APT70330	(Get FASTA)	NCBI Sequence Viewer
	BAA01721	(Get FASTA)	NCBI Sequence Viewer
	BAC06083	(Get FASTA)	NCBI Sequence Viewer
	BAF83619	(Get FASTA)	NCBI Sequence Viewer
	BAG36027	(Get FASTA)	NCBI Sequence Viewer
	EAW98335	(Get FASTA)	NCBI Sequence Viewer
	EAW98336	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000436714
	ENSP00000436714.2
GenBank Protein	P49019	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_006009 ⟸ NM_006018

- UniProtKB:

E9PI97 (UniProtKB/Swiss-Prot), B2R830 (UniProtKB/Swiss-Prot), A8K4G5 (UniProtKB/Swiss-Prot), Q8NGE4 (UniProtKB/Swiss-Prot), P49019 (UniProtKB/Swiss-Prot), A0A4Y1JWR6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRI
FLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFR
VVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAM
FLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFW
LLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGE
PDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGC
CIE

hide sequence

RefSeq Acc Id:

ENSP00000436714 ⟸ ENST00000528880

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P49019-F1-model_v2	AlphaFold	P49019	1-387	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:16824	AgrOrtholog
COSMIC	HCAR3	COSMIC
Ensembl Genes	ENSG00000255398	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000528880	ENTREZGENE
	ENST00000528880.3	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000255398	GTEx
HGNC ID	HGNC:16824	ENTREZGENE
Human Proteome Map	HCAR3	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:8843	UniProtKB/Swiss-Prot
NCBI Gene	8843	ENTREZGENE
OMIM	606039	OMIM
PANTHER	HYDROXYCARBOXYLIC ACID RECEPTOR 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46048:SF5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA165512827	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P2YPURNOCPTR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A4Y1JWR6	ENTREZGENE, UniProtKB/TrEMBL
	A8K4G5	ENTREZGENE
	B2R830	ENTREZGENE
	E9PI97	ENTREZGENE
	HCAR3_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q8NGE4	ENTREZGENE
UniProt Secondary	A8K4G5	UniProtKB/Swiss-Prot
	B2R830	UniProtKB/Swiss-Prot
	E9PI97	UniProtKB/Swiss-Prot
	Q8NGE4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-27	HCAR3	hydroxycarboxylic acid receptor 3	NIACR2	niacin receptor 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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