CAMLG (calcium modulating ligand)

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Keyword

Gene: CAMLG (calcium modulating ligand) Homo sapiens

Symbol:

CAMLG

Name:

calcium modulating ligand

Description:

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

calcium signal-modulating cyclophilin ligand; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; CAML; cyclophilin B-binding protein; MGC163197; OTTHUMP00000159378; OTTHUMP00000223128

Orthologs:

Mus musculus : Caml (calcium modulating ligand) MGI
Rattus norvegicus : Camlg (calcium modulating ligand)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	134,351,485 - 134,365,160	+	NCBI
Human Genome Assembly HuRef	5	129,260,141 - 129,273,526	+	NCBI
Human Genome Assembly GRCh37	5	134,074,170 - 134,087,850	+	NCBI
Human Genome Assembly Build 36	5	134,102,105 - 134,115,746	+	NCBI
Human Cytogenetic Map	5	q23		NCBI
Human Genome Assembly	5	134,102,104 - 134,115,740		NCBI