FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase)

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Keyword

Gene: FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase) Homo sapiens

Symbol:

FBXW7

Name:

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

Description:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

AGO; archipelago; archipelago homolog; archipelago, Drosophila, homolog of; CDC4; DKFZp686F23254; f-box and wd-40 domain protein 7 (archipelago homolog, drosophila); F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FBW6; FBW7; FBX30; FBXO30; FBXW6; FLJ16457; hAgo; hAgo; hCdc4; hCdc4; homolog of C elegans sel-10; SEL-10; SEL10

Orthologs:

Mus musculus : Fbxw7 (F-box and WD-40 domain protein 7) MGI
Rattus norvegicus : Fbxw7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	4	153,027,150 - 153,241,136	-	NCBI
Human Genome Assembly HuRef	4	148,968,491 - 149,182,492	-	NCBI
Human Genome Assembly GRCh37	4	153,242,410 - 153,456,393	-	NCBI
Human Genome Assembly Build 36	4	153,461,860 - 153,675,622	-	NCBI
Human Cytogenetic Map	4	q31.3		NCBI
Human Genome Assembly	4	153,601,099 - 153,690,635		NCBI