INSRR (insulin receptor related receptor) - Rat Genome Database

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Gene: INSRR (insulin receptor related receptor) Homo sapiens
Analyze
Symbol: INSRR
Name: insulin receptor related receptor
RGD ID: 1346961
HGNC Page HGNC:6093
Description: Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin cytoskeleton organization and cellular response to alkaline pH. Part of receptor complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: insulin receptor-related protein; insulin receptor-related receptor; IR-related receptor; IRR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,840,063 - 156,859,117 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,840,063 - 156,859,117 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,809,855 - 156,828,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,077,289 - 155,095,290 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,623,737 - 153,641,739NCBI
Celera1129,881,880 - 129,899,901 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,169,042 - 128,187,107 (-)NCBIHuRef
CHM1_11158,206,845 - 158,224,892 (-)NCBICHM1_1
T2T-CHM13v2.01155,976,882 - 155,995,951 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA,IEA)
insulin receptor complex  (IBA,IEA)
membrane  (IEA)
plasma membrane  (NAS)
receptor complex  (IDA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1326521   PMID:2249481   PMID:2768234   PMID:7649121   PMID:7829525   PMID:8916919   PMID:10226785   PMID:10329736   PMID:10535406   PMID:10640820   PMID:14654552   PMID:15629149  
PMID:16195402   PMID:18660489   PMID:20734064   PMID:21641549   PMID:21873635   PMID:22939624   PMID:23220417   PMID:23382219   PMID:23824460   PMID:24121506   PMID:25597417   PMID:28065597  
PMID:29156593   PMID:30898150   PMID:31615897   PMID:32296183   PMID:32708676   PMID:33111431   PMID:33961781   PMID:35384245   PMID:36724073   PMID:37099121  


Genomics

Comparative Map Data
INSRR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,840,063 - 156,859,117 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,840,063 - 156,859,117 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,809,855 - 156,828,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,077,289 - 155,095,290 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,623,737 - 153,641,739NCBI
Celera1129,881,880 - 129,899,901 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,169,042 - 128,187,107 (-)NCBIHuRef
CHM1_11158,206,845 - 158,224,892 (-)NCBICHM1_1
T2T-CHM13v2.01155,976,882 - 155,995,951 (-)NCBIT2T-CHM13v2.0
Insrr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,704,215 - 87,723,408 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,704,258 - 87,723,408 (+)EnsemblGRCm39 Ensembl
GRCm38387,796,908 - 87,816,101 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,796,951 - 87,816,101 (+)EnsemblGRCm38mm10GRCm38
MGSCv37387,600,873 - 87,620,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36387,882,989 - 87,902,028 (+)NCBIMGSCv36mm8
Celera387,834,770 - 87,853,941 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.7NCBI
Insrr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,553,244 - 175,572,676 (+)NCBIGRCr8
mRatBN7.22173,255,335 - 173,274,800 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,255,414 - 173,274,800 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,403,648 - 180,423,105 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,425,995 - 178,445,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,015,443 - 173,034,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,161,817 - 187,181,400 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,162,017 - 187,181,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,566,945 - 206,586,422 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,857,189 - 179,876,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,807,294 - 179,814,613 (+)NCBI
Celera2167,205,192 - 167,224,577 (+)NCBICelera
Cytogenetic Map2q34NCBI
Insrr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,911,691 - 2,928,326 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,911,691 - 2,928,335 (-)NCBIChiLan1.0ChiLan1.0
INSRR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2192,985,951 - 93,004,212 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,720,520 - 92,738,702 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,183,963 - 132,195,267 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,005,458 - 136,024,374 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,005,458 - 136,024,374 (-)Ensemblpanpan1.1panPan2
INSRR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,161,036 - 41,176,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,161,333 - 41,175,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,648,067 - 40,663,757 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,023,495 - 41,039,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,023,278 - 41,039,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,805,532 - 40,821,218 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,858,559 - 40,874,251 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,142,065 - 41,157,749 (+)NCBIUU_Cfam_GSD_1.0
Insrr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,951,859 - 26,970,037 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,983,006 - 5,999,994 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,982,259 - 5,999,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSRR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,239,969 - 93,258,075 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,239,678 - 93,258,075 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,811,817 - 101,830,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INSRR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,008,882 - 7,029,377 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,010,504 - 7,028,557 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,299,398 - 6,318,332 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insrr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,971,345 - 1,987,231 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,971,442 - 1,987,595 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in INSRR
98 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|See cases [RCV000051851] Chr1:156664483..160727411 [GRCh38]
Chr1:156634275..160697201 [GRCh37]
Chr1:154900899..158963825 [NCBI36]
Chr1:1q23.1-23.3
pathogenic
NM_014215.2(INSRR):c.3271G>A (p.Glu1091Lys) single nucleotide variant Malignant melanoma [RCV000059925] Chr1:156842238 [GRCh38]
Chr1:156812030 [GRCh37]
Chr1:155078654 [NCBI36]
Chr1:1q23.1
not provided
NM_014215.3(INSRR):c.3484G>A (p.Glu1162Lys) single nucleotide variant Inborn genetic diseases [RCV003173028] Chr1:156841708 [GRCh38]
Chr1:156811500 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2062T>C (p.Cys688Arg) single nucleotide variant Inborn genetic diseases [RCV003188861] Chr1:156845731 [GRCh38]
Chr1:156815523 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.229A>T (p.Thr77Ser) single nucleotide variant Inborn genetic diseases [RCV003184498] Chr1:156854160 [GRCh38]
Chr1:156823952 [GRCh37]
Chr1:1q23.1
uncertain significance
GRCh38/hg38 1q21.3-23.1(chr1:154566501-157624084)x3 copy number gain See cases [RCV000139902] Chr1:154566501..157624084 [GRCh38]
Chr1:154538977..157593874 [GRCh37]
Chr1:152805601..155860498 [NCBI36]
Chr1:1q21.3-23.1
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
NM_014215.3(INSRR):c.3237+45C>G single nucleotide variant not provided [RCV001547631] Chr1:156842353 [GRCh38]
Chr1:156812145 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.584C>A (p.Thr195Asn) single nucleotide variant Inborn genetic diseases [RCV003196084] Chr1:156853805 [GRCh38]
Chr1:156823597 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.818G>A (p.Arg273His) single nucleotide variant Inborn genetic diseases [RCV003191832] Chr1:156852011 [GRCh38]
Chr1:156821803 [GRCh37]
Chr1:1q23.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_014215.3(INSRR):c.1020G>A (p.Ala340=) single nucleotide variant not provided [RCV003312141] Chr1:156851710 [GRCh38]
Chr1:156821502 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3243C>A (p.Asn1081Lys) single nucleotide variant Inborn genetic diseases [RCV003277920] Chr1:156842266 [GRCh38]
Chr1:156812058 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.905C>A (p.Ala302Asp) single nucleotide variant Inborn genetic diseases [RCV003271368] Chr1:156851924 [GRCh38]
Chr1:156821716 [GRCh37]
Chr1:1q23.1
uncertain significance
Single allele inversion Pediatric metastatic thyroid tumour [RCV000585807] Chr1:154130985..156843877 [GRCh37]
Chr1:1q21.3-23.1
likely pathogenic
NM_014215.3(INSRR):c.3158A>G (p.Gln1053Arg) single nucleotide variant Inborn genetic diseases [RCV003304650] Chr1:156842477 [GRCh38]
Chr1:156812269 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2668G>A (p.Val890Ile) single nucleotide variant Inborn genetic diseases [RCV003255434] Chr1:156844531 [GRCh38]
Chr1:156814323 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3397+17G>T single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV000670814] Chr1:156842095 [GRCh38]
Chr1:156811887 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3397+8G>T single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV000667449] Chr1:156842104 [GRCh38]
Chr1:156811896 [GRCh37]
Chr1:1q23.1
uncertain significance
GRCh37/hg19 1q22-23.1(chr1:155636337-158024499)x1 copy number loss not provided [RCV000684658] Chr1:155636337..158024499 [GRCh37]
Chr1:1q22-23.1
pathogenic
GRCh37/hg19 1q22-23.1(chr1:155999570-156844432)x3 copy number gain not provided [RCV000684659] Chr1:155999570..156844432 [GRCh37]
Chr1:1q22-23.1
uncertain significance
NM_014215.3(INSRR):c.3397+9G>A single nucleotide variant Familial medullary thyroid carcinoma [RCV000708801]|Hereditary insensitivity to pain with anhidrosis [RCV000986435] Chr1:156842103 [GRCh38]
Chr1:156811895 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3397+4del deletion Familial medullary thyroid carcinoma [RCV000708802] Chr1:156842108 [GRCh38]
Chr1:156811900 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3319G>T (p.Ala1107Ser) single nucleotide variant Familial medullary thyroid carcinoma [RCV000708803]|not provided [RCV001726315] Chr1:156842190 [GRCh38]
Chr1:156811982 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3537dup (p.Val1180fs) duplication Familial medullary thyroid carcinoma [RCV000708800] Chr1:156841518..156841519 [GRCh38]
Chr1:156811310..156811311 [GRCh37]
Chr1:1q23.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
LMNA-NTRK1 fusion fusion Congenital fibrosarcoma [RCV000754610] Chr1:156100565..156844697 [GRCh37]
Chr1:1q22-23.1
pathogenic
NM_014215.3(INSRR):c.3397+98G>C single nucleotide variant not provided [RCV001585503] Chr1:156842014 [GRCh38]
Chr1:156811806 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3265T>C (p.Leu1089=) single nucleotide variant not provided [RCV001532552] Chr1:156842244 [GRCh38]
Chr1:156812036 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.1281C>G (p.Ser427=) single nucleotide variant not provided [RCV000905951] Chr1:156849409 [GRCh38]
Chr1:156819201 [GRCh37]
Chr1:1q23.1
benign
NM_014215.3(INSRR):c.3513C>T (p.Thr1171=) single nucleotide variant not provided [RCV000902371] Chr1:156841679 [GRCh38]
Chr1:156811471 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.1113C>T (p.Ser371=) single nucleotide variant not provided [RCV000883961] Chr1:156851406 [GRCh38]
Chr1:156821198 [GRCh37]
Chr1:1q23.1
benign
NM_014215.3(INSRR):c.2783C>T (p.Pro928Leu) single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV000986436] Chr1:156844235 [GRCh38]
Chr1:156814027 [GRCh37]
Chr1:1q23.1
benign
NM_014215.3(INSRR):c.259C>T (p.Arg87Cys) single nucleotide variant not provided [RCV000917574] Chr1:156854130 [GRCh38]
Chr1:156823922 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.775C>T (p.Leu259=) single nucleotide variant not provided [RCV000896316] Chr1:156852054 [GRCh38]
Chr1:156821846 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3761T>C (p.Phe1254Ser) single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV000986434] Chr1:156841006 [GRCh38]
Chr1:156810798 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1660C>T (p.Arg554Cys) single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV000986437]|not provided [RCV003411926] Chr1:156846669 [GRCh38]
Chr1:156816461 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.736T>C (p.Cys246Arg) single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV000986438]|not provided [RCV002511009] Chr1:156852093 [GRCh38]
Chr1:156821885 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.223C>T (p.Arg75Cys) single nucleotide variant Inborn genetic diseases [RCV003247944] Chr1:156854166 [GRCh38]
Chr1:156823958 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1786G>A (p.Val596Ile) single nucleotide variant Inborn genetic diseases [RCV003251422]|not provided [RCV003410317] Chr1:156846543 [GRCh38]
Chr1:156816335 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.1891C>A (p.Arg631Ser) single nucleotide variant Inborn genetic diseases [RCV003270771] Chr1:156846039 [GRCh38]
Chr1:156815831 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3028G>A (p.Val1010Met) single nucleotide variant Inborn genetic diseases [RCV003290787] Chr1:156843102 [GRCh38]
Chr1:156812894 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2289G>A (p.Gln763=) single nucleotide variant not provided [RCV000974863] Chr1:156845224 [GRCh38]
Chr1:156815016 [GRCh37]
Chr1:1q23.1
benign
NM_014215.3(INSRR):c.1811-5C>T single nucleotide variant not provided [RCV000911054] Chr1:156846124 [GRCh38]
Chr1:156815916 [GRCh37]
Chr1:1q23.1
benign
NM_014215.3(INSRR):c.3663-5A>G single nucleotide variant not provided [RCV000955791] Chr1:156841109 [GRCh38]
Chr1:156810901 [GRCh37]
Chr1:1q23.1
benign
NM_014215.3(INSRR):c.835C>T (p.Arg279Cys) single nucleotide variant not provided [RCV000912685] Chr1:156851994 [GRCh38]
Chr1:156821786 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.260G>A (p.Arg87His) single nucleotide variant Inborn genetic diseases [RCV003309810] Chr1:156854129 [GRCh38]
Chr1:156823921 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1785C>T (p.Ile595=) single nucleotide variant not provided [RCV001532554] Chr1:156846544 [GRCh38]
Chr1:156816336 [GRCh37]
Chr1:1q23.1
likely benign
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
NM_014215.3(INSRR):c.2796G>A (p.Thr932=) single nucleotide variant not provided [RCV001532553] Chr1:156844222 [GRCh38]
Chr1:156814014 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.406C>T (p.Arg136Cys) single nucleotide variant not provided [RCV001532555] Chr1:156853983 [GRCh38]
Chr1:156823775 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3397+23G>A single nucleotide variant Hereditary insensitivity to pain with anhidrosis [RCV003120119] Chr1:156842089 [GRCh38]
Chr1:156811881 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3366G>C (p.Met1122Ile) single nucleotide variant not provided [RCV001767458] Chr1:156842143 [GRCh38]
Chr1:156811935 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2454T>A (p.Ile818=) single nucleotide variant not provided [RCV001816066] Chr1:156844827 [GRCh38]
Chr1:156814619 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.2250C>T (p.Pro750=) single nucleotide variant not provided [RCV001815684] Chr1:156845263 [GRCh38]
Chr1:156815055 [GRCh37]
Chr1:1q23.1
likely benign
NC_000001.10:g.(?_155581953)_(156851434_?)del deletion Charcot-Marie-Tooth disease type 2 [RCV001983077] Chr1:155581953..156851434 [GRCh37]
Chr1:1q22-23.1
pathogenic
GRCh37/hg19 1q23.1(chr1:156665257-156902706)x1 copy number loss not provided [RCV001829219] Chr1:156665257..156902706 [GRCh37]
Chr1:1q23.1
uncertain significance
NC_000001.10:g.(?_149895434)_(156851434_?)dup duplication Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency [RCV001958273]|Congenital neutropenia-myelofibrosis-nephromegaly syndrome [RCV001958271]|Kostmann syndrome [RCV003120769]|MHC class II deficiency [RCV001992607] Chr1:149895434..156851434 [GRCh37]
Chr1:1q21.2-23.1
uncertain significance
NC_000001.10:g.(?_154141761)_(156851434_?)dup duplication Charcot-Marie-Tooth disease type 2 [RCV001990060] Chr1:154141761..156851434 [GRCh37]
Chr1:1q21.3-23.1
uncertain significance
NM_014215.3(INSRR):c.1215C>T (p.Asp405=) single nucleotide variant not provided [RCV002211116] Chr1:156851304 [GRCh38]
Chr1:156821096 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3789G>A (p.Pro1263=) single nucleotide variant not provided [RCV002211115] Chr1:156840978 [GRCh38]
Chr1:156810770 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.1945G>A (p.Gly649Ser) single nucleotide variant Inborn genetic diseases [RCV003305783] Chr1:156845985 [GRCh38]
Chr1:156815777 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3538G>C (p.Val1180Leu) single nucleotide variant Inborn genetic diseases [RCV003280247] Chr1:156841518 [GRCh38]
Chr1:156811310 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3857G>A (p.Arg1286Lys) single nucleotide variant Inborn genetic diseases [RCV003275944] Chr1:156840910 [GRCh38]
Chr1:156810702 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.879C>T (p.Phe293=) single nucleotide variant not provided [RCV002262252] Chr1:156851950 [GRCh38]
Chr1:156821742 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.789G>A (p.Pro263=) single nucleotide variant not provided [RCV002262253] Chr1:156852040 [GRCh38]
Chr1:156821832 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.2700T>G (p.Ser900=) single nucleotide variant not provided [RCV002262251] Chr1:156844499 [GRCh38]
Chr1:156814291 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.56C>T (p.Ser19Phe) single nucleotide variant not provided [RCV002511597] Chr1:156858566 [GRCh38]
Chr1:156828358 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.376G>A (p.Val126Met) single nucleotide variant Inborn genetic diseases [RCV002974672] Chr1:156854013 [GRCh38]
Chr1:156823805 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.535G>A (p.Val179Met) single nucleotide variant Inborn genetic diseases [RCV002997809] Chr1:156853854 [GRCh38]
Chr1:156823646 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2525C>T (p.Pro842Leu) single nucleotide variant Inborn genetic diseases [RCV002947015] Chr1:156844756 [GRCh38]
Chr1:156814548 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1948G>T (p.Asp650Tyr) single nucleotide variant Inborn genetic diseases [RCV002818716] Chr1:156845982 [GRCh38]
Chr1:156815774 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.201C>T (p.Asp67=) single nucleotide variant not provided [RCV002511596] Chr1:156854188 [GRCh38]
Chr1:156823980 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.1883C>G (p.Pro628Arg) single nucleotide variant Inborn genetic diseases [RCV002974041] Chr1:156846047 [GRCh38]
Chr1:156815839 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.524A>G (p.Glu175Gly) single nucleotide variant Inborn genetic diseases [RCV002773308] Chr1:156853865 [GRCh38]
Chr1:156823657 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3188C>A (p.Thr1063Asn) single nucleotide variant Inborn genetic diseases [RCV002858905] Chr1:156842447 [GRCh38]
Chr1:156812239 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3625G>A (p.Gly1209Arg) single nucleotide variant Inborn genetic diseases [RCV002733912] Chr1:156841431 [GRCh38]
Chr1:156811223 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3286G>A (p.Ala1096Thr) single nucleotide variant Inborn genetic diseases [RCV002794511] Chr1:156842223 [GRCh38]
Chr1:156812015 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2468C>T (p.Ala823Val) single nucleotide variant Inborn genetic diseases [RCV002783748] Chr1:156844813 [GRCh38]
Chr1:156814605 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1141T>C (p.Phe381Leu) single nucleotide variant Inborn genetic diseases [RCV002707512] Chr1:156851378 [GRCh38]
Chr1:156821170 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2887G>A (p.Ala963Thr) single nucleotide variant Inborn genetic diseases [RCV002706953] Chr1:156843436 [GRCh38]
Chr1:156813228 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1796G>A (p.Arg599Gln) single nucleotide variant Inborn genetic diseases [RCV002998578] Chr1:156846533 [GRCh38]
Chr1:156816325 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3538G>A (p.Val1180Met) single nucleotide variant Inborn genetic diseases [RCV002978337] Chr1:156841518 [GRCh38]
Chr1:156811310 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1043C>T (p.Thr348Met) single nucleotide variant Inborn genetic diseases [RCV002869498] Chr1:156851687 [GRCh38]
Chr1:156821479 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2423G>T (p.Arg808Leu) single nucleotide variant Inborn genetic diseases [RCV002887064] Chr1:156845090 [GRCh38]
Chr1:156814882 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1979G>A (p.Gly660Asp) single nucleotide variant Inborn genetic diseases [RCV002821956] Chr1:156845814 [GRCh38]
Chr1:156815606 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1043C>A (p.Thr348Lys) single nucleotide variant Inborn genetic diseases [RCV002694743] Chr1:156851687 [GRCh38]
Chr1:156821479 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1388G>T (p.Arg463Leu) single nucleotide variant Inborn genetic diseases [RCV002739494] Chr1:156849302 [GRCh38]
Chr1:156819094 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2362C>A (p.His788Asn) single nucleotide variant Inborn genetic diseases [RCV002691367] Chr1:156845151 [GRCh38]
Chr1:156814943 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2477C>T (p.Ala826Val) single nucleotide variant Inborn genetic diseases [RCV002826866] Chr1:156844804 [GRCh38]
Chr1:156814596 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.29G>A (p.Gly10Glu) single nucleotide variant Inborn genetic diseases [RCV002854265] Chr1:156858593 [GRCh38]
Chr1:156828385 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2709C>G (p.Asp903Glu) single nucleotide variant Inborn genetic diseases [RCV002645296] Chr1:156844490 [GRCh38]
Chr1:156814282 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.917C>G (p.Ser306Cys) single nucleotide variant Inborn genetic diseases [RCV002916219] Chr1:156851912 [GRCh38]
Chr1:156821704 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3805C>T (p.Arg1269Trp) single nucleotide variant Inborn genetic diseases [RCV003004067] Chr1:156840962 [GRCh38]
Chr1:156810754 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3751C>T (p.Arg1251Trp) single nucleotide variant Inborn genetic diseases [RCV002805200] Chr1:156841016 [GRCh38]
Chr1:156810808 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1736C>G (p.Thr579Arg) single nucleotide variant Inborn genetic diseases [RCV002641253] Chr1:156846593 [GRCh38]
Chr1:156816385 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2504G>T (p.Arg835Leu) single nucleotide variant Inborn genetic diseases [RCV002849729] Chr1:156844777 [GRCh38]
Chr1:156814569 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3470G>T (p.Arg1157Leu) single nucleotide variant Inborn genetic diseases [RCV002747968] Chr1:156841722 [GRCh38]
Chr1:156811514 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3736A>T (p.Ile1246Leu) single nucleotide variant Inborn genetic diseases [RCV002935815] Chr1:156841031 [GRCh38]
Chr1:156810823 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3748C>A (p.Leu1250Met) single nucleotide variant Inborn genetic diseases [RCV002672650] Chr1:156841019 [GRCh38]
Chr1:156810811 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2659T>G (p.Ser887Ala) single nucleotide variant Inborn genetic diseases [RCV002831712] Chr1:156844540 [GRCh38]
Chr1:156814332 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.127C>T (p.Arg43Cys) single nucleotide variant Inborn genetic diseases [RCV002987889] Chr1:156854262 [GRCh38]
Chr1:156824054 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2503C>T (p.Arg835Cys) single nucleotide variant Inborn genetic diseases [RCV002921256] Chr1:156844778 [GRCh38]
Chr1:156814570 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.547G>A (p.Val183Met) single nucleotide variant Inborn genetic diseases [RCV002807884] Chr1:156853842 [GRCh38]
Chr1:156823634 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.992G>T (p.Gly331Val) single nucleotide variant Inborn genetic diseases [RCV002680238] Chr1:156851738 [GRCh38]
Chr1:156821530 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2086G>A (p.Gly696Ser) single nucleotide variant Inborn genetic diseases [RCV002680166] Chr1:156845707 [GRCh38]
Chr1:156815499 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3880G>T (p.Gly1294Cys) single nucleotide variant Inborn genetic diseases [RCV002724765] Chr1:156840887 [GRCh38]
Chr1:156810679 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.407G>A (p.Arg136His) single nucleotide variant Inborn genetic diseases [RCV002722525] Chr1:156853982 [GRCh38]
Chr1:156823774 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.748C>T (p.Arg250Cys) single nucleotide variant Inborn genetic diseases [RCV002677167] Chr1:156852081 [GRCh38]
Chr1:156821873 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3601G>T (p.Val1201Leu) single nucleotide variant Inborn genetic diseases [RCV003218779] Chr1:156841455 [GRCh38]
Chr1:156811247 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.285C>T (p.Arg95=) single nucleotide variant not provided [RCV003222640] Chr1:156854104 [GRCh38]
Chr1:156823896 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.430A>G (p.Asn144Asp) single nucleotide variant Inborn genetic diseases [RCV003197252] Chr1:156853959 [GRCh38]
Chr1:156823751 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.380C>A (p.Ala127Glu) single nucleotide variant not provided [RCV003334110] Chr1:156854009 [GRCh38]
Chr1:156823801 [GRCh37]
Chr1:1q23.1
likely benign
GRCh37/hg19 1q12-23.1(chr1:142535935-157648813)x3 copy number gain Chromosome 1q21.1 duplication syndrome [RCV003329522] Chr1:142535935..157648813 [GRCh37]
Chr1:1q12-23.1
pathogenic
NM_014215.3(INSRR):c.2905C>A (p.Pro969Thr) single nucleotide variant Inborn genetic diseases [RCV003341410] Chr1:156843225 [GRCh38]
Chr1:156813017 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.1006G>A (p.Asp336Asn) single nucleotide variant Inborn genetic diseases [RCV003384721] Chr1:156851724 [GRCh38]
Chr1:156821516 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2515C>A (p.Pro839Thr) single nucleotide variant Inborn genetic diseases [RCV003373979] Chr1:156844766 [GRCh38]
Chr1:156814558 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.2171C>T (p.Pro724Leu) single nucleotide variant Inborn genetic diseases [RCV003343190] Chr1:156845622 [GRCh38]
Chr1:156815414 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3190C>T (p.Arg1064Cys) single nucleotide variant Inborn genetic diseases [RCV003353781] Chr1:156842445 [GRCh38]
Chr1:156812237 [GRCh37]
Chr1:1q23.1
uncertain significance
NM_014215.3(INSRR):c.3339C>T (p.His1113=) single nucleotide variant not provided [RCV003409158] Chr1:156842170 [GRCh38]
Chr1:156811962 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.3042G>A (p.Thr1014=) single nucleotide variant not provided [RCV003409159] Chr1:156843088 [GRCh38]
Chr1:156812880 [GRCh37]
Chr1:1q23.1
likely benign
NM_014215.3(INSRR):c.534C>T (p.Asp178=) single nucleotide variant not provided [RCV003409160] Chr1:156853855 [GRCh38]
Chr1:156823647 [GRCh37]
Chr1:1q23.1
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:712
Count of miRNA genes:454
Interacting mature miRNAs:513
Transcripts:ENST00000368195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S1179  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371156,824,860 - 156,825,048UniSTSGRCh37
GRCh371590,893,035 - 90,893,386UniSTSGRCh37
Build 361155,091,484 - 155,091,672RGDNCBI36
Celera1129,896,075 - 129,896,283RGD
Celera1567,297,374 - 67,297,725UniSTS
Cytogenetic Map1q21-q23UniSTS
HuRef1567,005,280 - 67,005,631UniSTS
HuRef1128,183,237 - 128,183,445UniSTS
Marshfield Genetic Map1161.05RGD
Marshfield Genetic Map1161.05UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 7 4 2 20 7 13 10 1 2
Low 523 107 522 15 51 7 354 133 1367 183 876 262 8 1 467 290 1 1
Below cutoff 1739 2616 964 424 1246 274 3518 2005 2214 88 435 1117 154 721 2267 2

Sequence


RefSeq Acc Id: ENST00000368195   ⟹   ENSP00000357178
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,840,063 - 156,859,117 (-)Ensembl
RefSeq Acc Id: NM_014215   ⟹   NP_055030
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,840,063 - 156,859,117 (-)NCBI
GRCh371156,810,665 - 156,828,712 (-)ENTREZGENE
Build 361155,077,289 - 155,095,290 (-)NCBI Archive
HuRef1128,169,042 - 128,187,107 (-)ENTREZGENE
CHM1_11158,206,845 - 158,224,892 (-)NCBI
T2T-CHM13v2.01155,976,882 - 155,995,951 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_055030 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC17167 (Get FASTA)   NCBI Sequence Viewer  
  AAC31759 (Get FASTA)   NCBI Sequence Viewer  
  AFM93766 (Get FASTA)   NCBI Sequence Viewer  
  EAW52903 (Get FASTA)   NCBI Sequence Viewer  
  EAW52904 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000357178
  ENSP00000357178.3
GenBank Protein P14616 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_055030   ⟸   NM_014215
- Peptide Label: precursor
- UniProtKB: O60724 (UniProtKB/Swiss-Prot),   Q5VZS3 (UniProtKB/Swiss-Prot),   P14616 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000357178   ⟸   ENST00000368195
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14616-F1-model_v2 AlphaFold P14616 1-1297 view protein structure

Promoters
RGD ID:6785790
Promoter ID:HG_KWN:5580
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:OTTHUMT00000098929,   UC009WSJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361155,095,226 - 155,095,726 (-)MPROMDB
RGD ID:6857632
Promoter ID:EPDNEW_H1981
Type:initiation region
Name:INSRR_1
Description:insulin receptor related receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,859,092 - 156,859,152EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6093 AgrOrtholog
COSMIC INSRR COSMIC
Ensembl Genes ENSG00000027644 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000368195 ENTREZGENE
  ENST00000368195.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000027644 GTEx
HGNC ID HGNC:6093 ENTREZGENE
Human Proteome Map INSRR Human Proteome Map
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_insulin-like_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot
KEGG Report hsa:3645 UniProtKB/Swiss-Prot
NCBI Gene 3645 ENTREZGENE
OMIM 147671 OMIM
PANTHER PTHR24416:SF338 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29899 PharmGKB
PIRSF Insulin_receptor UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot
SMART FN3 UniProtKB/Swiss-Prot
  SM00261 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt I6U4P1_HUMAN UniProtKB/TrEMBL
  INSRR_HUMAN UniProtKB/Swiss-Prot
  O60724 ENTREZGENE
  P14616 ENTREZGENE
  Q5VZS3 ENTREZGENE
UniProt Secondary O60724 UniProtKB/Swiss-Prot
  Q5VZS3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 INSRR  insulin receptor related receptor    insulin receptor-related receptor  Symbol and/or name change 5135510 APPROVED