Gene: PARD6A (par-6 partitioning defective 6 homolog alpha (C. elegans))
Homo sapiens
Symbol:
PARD6A
Name:
par-6 partitioning defective 6 homolog alpha (C. elegans)
Description:
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
OTTHUMP00000174836; PAR-6 alpha; par-6 partitioning defective 6 homolog alpha (c.elegans); PAR-6A; PAR6; PAR6alpha; PAR6C; partitioning defective 6 homolog alpha; partitioning defective-6 homolog alpha; partitioning-defective protein 6; tax interaction protein 40; Tax-interacting protein 40; TAX40; TIP-40
Orthologs:
Mus musculus : Pard6a
(par-6 (partitioning defective 6,) homolog alpha (C. elegans))
MGI
Pard6a
(par-6 (partitioning defective 6,) homolog alpha (C. elegans))
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 16 68,701,151 - 68,702,981 + NCBI Human Genome Assembly HuRef 16 53,567,763 - 53,569,593 + NCBI Human Genome Assembly GRCh37 16 67,694,851 - 67,696,681 + NCBI Human Genome Assembly Build 36 16 66,252,352 - 66,254,182 + NCBI Human Cytogenetic Map 16 q22.1 NCBI Human Genome Assembly 16 66,252,362 - 66,254,177 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol multiple interactions ISO RGD:1551602 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARD6A mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1551602 6480464 Ethinyl Estradiol affects the expression of PARD6A mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1551602 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARD6A mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551602 6480464 Tetrachlorodibenzodioxin affects the expression of PARD6A mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1303273 6480464 2,4-dinitrotoluene affects the expression of PARD6A mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1303273 6480464 2,6-dinitrotoluene affects the expression of PARD6A mRNA CTD PMID:21346803 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of PARD6A mRNA CTD PMID:21179406 benzo[a]pyrene multiple interactions ISO RGD:1551602 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PARD6A mRNA CTD PMID:21715664 benzo[a]pyrene increases expression ISO RGD:1551602 6480464 Benzo(a)pyrene results in increased expression of PARD6A mRNA CTD PMID:22228805 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PARD6A protein CTD PMID:16803524 copper(2+) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of PARD6A mRNA CTD PMID:19549813 cytarabine decreases expression EXP 6480464 Cytarabine results in decreased expression of PARD6A mRNA CTD PMID:19194470 N-nitrosodiethylamine increases expression ISO RGD:1551602 6480464 Diethylnitrosamine results in increased expression of PARD6A mRNA CTD PMID:17942915 N-nitrosodiethylamine multiple interactions ISO RGD:1551602 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PARD6A mRNA] CTD PMID:17942915
Gene Ontology Annotations
Biological Process cell cycle IEA UniProtKB-KW:KW-0131 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 cell division IEA UniProtKB-KW:KW-0132 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 cell junction assembly TAS 2290271 Reactome:REACT_20676 Reactome Reactome:REACT_20676 cell-cell junction maintenance ISS UniProtKB:Q9Z101 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 cell-cell junction organization TAS 2290271 Reactome:REACT_19331 Reactome Reactome:REACT_19331 tight junction assembly TAS 2290271 Reactome:REACT_19373 Reactome Reactome:REACT_19373 transforming growth factor beta receptor signaling pathway TAS 2290271 Reactome:REACT_6844 Reactome Reactome:REACT_6844 transforming growth factor beta receptor signaling pathway TAS 2290271 Reactome:REACT_120726 Reactome Reactome:REACT_120726 viral reproduction TAS 2290271 PMID:9482110 PINC PMID:9482110
1300036 BW29_H Body weight QTL 29 (human) 2.55 Body weight body mass index 16 49113595 75113595 Human 1358850 MULTSCL10_H Multiple sclerosis susceptibility QTL 10 (human) Multiple sclerosis susceptibility 16 66124225 90185220 Human 1578609 SCL125_H Serum cholesterol level QTL 125 (human) 1.5 Lipid level triglyceride 16 6043155 86386413 Human 1559231 SCL79_H Serum cholesterol level QTL 79 (human) 2.62 Lipid level triglyceride 16 66359506 90185220 Human 1581527 BP70_H Blood pressure QTL 70 (human) 2.2 .001 Blood pressure pulse pressure 16 58735205 84735205 Human 2289240 BW147_H Body weight QTL 147 (human) 2.54 .0003 Body weight BMI 16 53670735 86516334 Human 1643310 BW236_H Body weight QTL 236 (human) 1.26 Body weight body mass index 16 42999684 68999684 Human 2289204 BW362_H Body weight QTL 362 (human) .0221 Body fat amount percent fat 16 63683467 89683467 Human 1643055 BW115_H Body Weight QTL 115 (human) 2.59 .00028 Body weight 16 58735205 84735205 Human 2289460 BW216_H Body weight QTL 216 (human) 1.57 Body weight BMI 16 50598916 76598916 Human 2289478 SLEP18_H Serum leptin level QTL 18 (human) 2.98 Hormone level leptin 16 50598916 76598916 Human 2293479 PRSTS287_H Prostate tumor susceptibility QTL 287 (human) Prostate tumor susceptibility 16 66045003 90185220 Human 2292949 PRSTS151_H Prostate tumor susceptibility QTL 151 (human) 5.13 .000055 Prostate tumor susceptibility 16 50598916 76598916 Human 2301150 PRSTS400_H Prostate tumor susceptibility QTL 400 (human) 1.59 Prostate tumor susceptibility 16 66124225 90185220 Human
Gene Ontology Annotations
