CCT4 (chaperonin containing TCP1 subunit 4) - Rat Genome Database

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Gene: CCT4 (chaperonin containing TCP1 subunit 4) Homo sapiens
Analyze
Symbol: CCT4
Name: chaperonin containing TCP1 subunit 4
RGD ID: 1345648
HGNC Page HGNC:1617
Description: Enables protein folding chaperone. Involved in several processes, including positive regulation of establishment of protein localization to telomere; positive regulation of telomerase RNA localization to Cajal body; and positive regulation of telomere maintenance via telomerase. Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of chaperonin-containing T-complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCT-DELTA; Cctd; chaperonin containing t-complex polypeptide 1, delta subunit; chaperonin containing TCP1, subunit 4 (delta); MGC126164; MGC126165; SRB; stimulator of TAR RNA-binding; T-complex protein 1 subunit delta; TCP-1-delta
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CCT4P1   CCT4P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,868,085 - 61,888,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,868,085 - 61,888,671 (-)EnsemblGRCh38hg38GRCh38
GRCh37262,095,220 - 62,115,806 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,948,766 - 61,969,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 34262,006,913 - 62,027,442NCBI
Celera261,940,173 - 61,960,736 (-)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,835,217 - 61,855,722 (-)NCBIHuRef
CHM1_1262,025,224 - 62,045,751 (-)NCBICHM1_1
T2T-CHM13v2.0261,874,246 - 61,894,829 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (EXP)
aminoglutethimide  (EXP)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
caffeine  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (EXP)
chromium(6+)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dinophysistoxin 1  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indirubin  (EXP)
indometacin  (EXP)
ivermectin  (EXP)
L-serine  (EXP)
methapyrilene  (EXP)
nefazodone  (ISO)
nimesulide  (ISO)
okadaic acid  (EXP)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
PhIP  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (EXP)
sodium arsenite  (EXP)
sulindac  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
trimellitic anhydride  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
zinc sulfate  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene. Lee MJ, etal., Hum Mol Genet 2003 Aug 1;12(15):1917-25.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7953530   PMID:8626763   PMID:8661059   PMID:8889549   PMID:9153422   PMID:9819444   PMID:10604479   PMID:11580270   PMID:11689615   PMID:12477932   PMID:12665801   PMID:14532270  
PMID:15489334   PMID:15815621   PMID:15967112   PMID:16009940   PMID:16055720   PMID:16085932   PMID:16341674   PMID:16344560   PMID:16497536   PMID:17081065   PMID:17110338   PMID:17314511  
PMID:17550899   PMID:17643375   PMID:18029348   PMID:18715871   PMID:18775504   PMID:18782753   PMID:19135240   PMID:19156129   PMID:19380743   PMID:19738201   PMID:20080638   PMID:20193073  
PMID:20458337   PMID:20467437   PMID:20473970   PMID:21081503   PMID:21081666   PMID:21145461   PMID:21319273   PMID:21360678   PMID:21525035   PMID:21654808   PMID:21726808   PMID:21873635  
PMID:21900206   PMID:21942715   PMID:22079093   PMID:22133715   PMID:22199357   PMID:22268729   PMID:22304920   PMID:22623428   PMID:22658674   PMID:22810585   PMID:22863883   PMID:22939629  
PMID:23011926   PMID:23125841   PMID:23184937   PMID:23349634   PMID:23376485   PMID:23383273   PMID:23398456   PMID:23438482   PMID:23443559   PMID:23455922   PMID:23463506   PMID:23533145  
PMID:23612981   PMID:23658844   PMID:23752268   PMID:24298020   PMID:24320561   PMID:24366813   PMID:24711643   PMID:24846140   PMID:24980433   PMID:24981860   PMID:25144556   PMID:25147182  
PMID:25192599   PMID:25306918   PMID:25315684   PMID:25324306   PMID:25342745   PMID:25437307   PMID:25467444   PMID:25499913   PMID:25737280   PMID:25756610   PMID:25798074   PMID:25817432  
PMID:25852190   PMID:25900982   PMID:25921289   PMID:25940091   PMID:25944111   PMID:25959826   PMID:25963833   PMID:26186194   PMID:26217791   PMID:26344197   PMID:26446488   PMID:26460568  
PMID:26472337   PMID:26472760   PMID:26496610   PMID:26549023   PMID:26618866   PMID:26638075   PMID:26693507   PMID:26725010   PMID:26811472   PMID:26816005   PMID:26831064   PMID:26972000  
PMID:27025967   PMID:27114451   PMID:27353360   PMID:27375898   PMID:27462432   PMID:27503909   PMID:27591049   PMID:27684187   PMID:27705803   PMID:27880917   PMID:28027390   PMID:28330616  
PMID:28443643   PMID:28514442   PMID:28515276   PMID:28561026   PMID:28581483   PMID:28675297   PMID:28685749   PMID:28718761   PMID:28902428   PMID:29117863   PMID:29229926   PMID:29298432  
PMID:29331416   PMID:29395067   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29511261   PMID:29531219   PMID:29568061   PMID:29845934   PMID:29955894   PMID:29969578   PMID:29991511  
PMID:30021884   PMID:30097533   PMID:30209976   PMID:30258100   PMID:30274258   PMID:30425250   PMID:30442662   PMID:30455355   PMID:30463901   PMID:30559450   PMID:30575818   PMID:30711629  
PMID:30745168   PMID:30809309   PMID:30833792   PMID:30890647   PMID:30948266   PMID:30955883   PMID:31067453   PMID:31091453   PMID:31152661   PMID:31239290   PMID:31300519   PMID:31405213  
PMID:31409639   PMID:31501420   PMID:31527615   PMID:31586073   PMID:31620119   PMID:31685992   PMID:31732153   PMID:31751430   PMID:31980649   PMID:31995728   PMID:32129710   PMID:32296183  
PMID:32416067   PMID:32513696   PMID:32529326   PMID:32552912   PMID:32687490   PMID:32698014   PMID:32707033   PMID:32786267   PMID:32807901   PMID:32814769   PMID:32877691   PMID:32929329  
PMID:32994395   PMID:33022573   PMID:33024031   PMID:33137104   PMID:33144677   PMID:33226137   PMID:33239621   PMID:33306668   PMID:33397691   PMID:33545068   PMID:33567341   PMID:33644029  
PMID:33729478   PMID:33762435   PMID:33777788   PMID:33863777   PMID:33916271   PMID:33961781   PMID:34004371   PMID:34079125   PMID:34133714   PMID:34185411   PMID:34316702   PMID:34373451  
PMID:34428256   PMID:34645483   PMID:34650049   PMID:34687317   PMID:34728620   PMID:34732665   PMID:34732716   PMID:35008187   PMID:35013218   PMID:35102251   PMID:35140242   PMID:35256949  
PMID:35271311   PMID:35366418   PMID:35411049   PMID:35446349   PMID:35509820   PMID:35530310   PMID:35545034   PMID:35546148   PMID:35562734   PMID:35563538   PMID:35676659   PMID:35776542  
PMID:35777956   PMID:35821088   PMID:35831314   PMID:35844135   PMID:35850772   PMID:35944360   PMID:36055981   PMID:36057605   PMID:36102200   PMID:36129980   PMID:36168627   PMID:36180891  
PMID:36215168   PMID:36252997   PMID:36282215   PMID:36414381   PMID:36424410   PMID:36517590   PMID:36526897   PMID:36574265   PMID:36610398   PMID:36762613   PMID:36912080   PMID:37120454  
PMID:37232246   PMID:37536630   PMID:37689310   PMID:37827155   PMID:38113892   PMID:38172120   PMID:38216268   PMID:38245532  


Genomics

Comparative Map Data
CCT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,868,085 - 61,888,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,868,085 - 61,888,671 (-)EnsemblGRCh38hg38GRCh38
GRCh37262,095,220 - 62,115,806 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,948,766 - 61,969,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 34262,006,913 - 62,027,442NCBI
Celera261,940,173 - 61,960,736 (-)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,835,217 - 61,855,722 (-)NCBIHuRef
CHM1_1262,025,224 - 62,045,751 (-)NCBICHM1_1
T2T-CHM13v2.0261,874,246 - 61,894,829 (-)NCBIT2T-CHM13v2.0
Cct4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391122,940,593 - 22,953,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1122,940,519 - 22,953,780 (+)EnsemblGRCm39 Ensembl
GRCm381122,990,593 - 23,003,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1122,990,519 - 23,003,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,890,593 - 22,903,336 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,890,593 - 22,903,336 (+)NCBIMGSCv36mm8
Celera1125,126,226 - 25,138,969 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.25NCBI
Cct4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,193,057 - 101,205,935 (+)NCBIGRCr8
mRatBN7.21496,991,853 - 97,004,732 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1496,991,859 - 97,005,267 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,325,100 - 101,337,974 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,567,399 - 102,580,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,039,002 - 99,051,876 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014107,767,392 - 107,780,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14107,767,392 - 107,780,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014107,843,411 - 107,856,260 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414103,675,110 - 103,687,893 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114103,694,320 - 103,707,104 (+)NCBI
Celera1495,973,133 - 95,985,983 (+)NCBICelera
Cytogenetic Map14q22NCBI
Cct4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542422,088,949 - 22,108,514 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542422,088,949 - 22,108,514 (+)NCBIChiLan1.0ChiLan1.0
CCT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21264,495,636 - 64,516,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A64,499,652 - 64,519,655 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,950,477 - 61,970,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A63,084,090 - 63,104,530 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A63,084,090 - 63,105,216 (-)Ensemblpanpan1.1panPan2
CCT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,859,148 - 61,874,030 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,859,245 - 61,874,389 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1061,748,927 - 61,763,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01062,867,889 - 62,882,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,867,244 - 62,882,587 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11062,551,782 - 62,566,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,855,534 - 62,870,428 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01063,151,020 - 63,165,931 (-)NCBIUU_Cfam_GSD_1.0
Cct4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,330,016 - 21,346,300 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364917,224,692 - 7,241,358 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364917,224,989 - 7,241,348 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl379,924,507 - 79,946,207 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1379,924,338 - 79,941,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2383,760,065 - 83,777,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,086,932 - 45,106,922 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,086,920 - 45,111,271 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604566,727,959 - 66,748,110 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cct4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462483346,076 - 62,665 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462483346,071 - 62,665 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCT4
21 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p16.1-15(chr2:59658846-62336083)x1 copy number loss See cases [RCV000050796] Chr2:59658846..62336083 [GRCh38]
Chr2:59885981..62563218 [GRCh37]
Chr2:59739485..62416722 [NCBI36]
Chr2:2p16.1-15
pathogenic
GRCh38/hg38 2p16.1-15(chr2:60009106-62006709)x3 copy number gain See cases [RCV000052660] Chr2:60009106..62006709 [GRCh38]
Chr2:60236241..62233844 [GRCh37]
Chr2:60089745..62087348 [NCBI36]
Chr2:2p16.1-15
uncertain significance
GRCh38/hg38 2p16.1-15(chr2:56738054-62473668)x1 copy number loss See cases [RCV000054020] Chr2:56738054..62473668 [GRCh38]
Chr2:56965189..62700803 [GRCh37]
Chr2:56818693..62554307 [NCBI36]
Chr2:2p16.1-15
pathogenic
GRCh38/hg38 2p16.1-14(chr2:58873039-64190332)x1 copy number loss See cases [RCV000054022] Chr2:58873039..64190332 [GRCh38]
Chr2:59100174..64417466 [GRCh37]
Chr2:58953678..64270970 [NCBI36]
Chr2:2p16.1-14
pathogenic
GRCh38/hg38 2p15(chr2:61515438-62305848)x1 copy number loss See cases [RCV000054053] Chr2:61515438..62305848 [GRCh38]
Chr2:61742573..62532983 [GRCh37]
Chr2:61596077..62386487 [NCBI36]
Chr2:2p15
pathogenic
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh38/hg38 2p16.1-15(chr2:58031916-63611810)x1 copy number loss See cases [RCV000143007] Chr2:58031916..63611810 [GRCh38]
Chr2:58259051..63838944 [GRCh37]
Chr2:58112555..63692448 [NCBI36]
Chr2:2p16.1-15
pathogenic
GRCh37/hg19 2p16.1-15(chr2:60405806-62442792)x3 copy number gain See cases [RCV000239924] Chr2:60405806..62442792 [GRCh37]
Chr2:2p16.1-15
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p16.1-15(chr2:57445335-62733206) copy number loss not provided [RCV000767552] Chr2:57445335..62733206 [GRCh37]
Chr2:2p16.1-15
likely pathogenic
GRCh37/hg19 2p16.1-15(chr2:58837279-63720819)x1 copy number loss See cases [RCV000449133] Chr2:58837279..63720819 [GRCh37]
Chr2:2p16.1-15
pathogenic
NC_000002.12:g.(?_61374256)_(62493432_?)dup duplication Schizophrenia [RCV000416716] Chr2:61374256..62493432 [GRCh38]
Chr2:61601391..62720567 [GRCh37]
Chr2:61454895..62574071 [NCBI36]
Chr2:2p15
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p15-14(chr2:61701437-65731084)x1 copy number loss See cases [RCV000511169] Chr2:61701437..65731084 [GRCh37]
Chr2:2p15-14
likely pathogenic
NM_006430.4(CCT4):c.59G>A (p.Gly20Glu) single nucleotide variant Inborn genetic diseases [RCV003267559] Chr2:61888449 [GRCh38]
Chr2:62115584 [GRCh37]
Chr2:2p15
uncertain significance
GRCh37/hg19 2p16.1-15(chr2:60308869-62368583) copy number gain Global developmental delay [RCV000626531] Chr2:60308869..62368583 [GRCh37]
Chr2:2p16.1-15
likely pathogenic
GRCh37/hg19 2p15(chr2:61576332-62775261) copy number gain Macrocephaly [RCV000626530] Chr2:61576332..62775261 [GRCh37]
Chr2:2p15
uncertain significance
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele duplication Schizophrenia [RCV000754267] Chr2:61372285..62496451 [GRCh38]
Chr2:2p15
likely pathogenic
GRCh37/hg19 2p15(chr2:61968083-62238312)x1 copy number loss not provided [RCV000847794] Chr2:61968083..62238312 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.121G>A (p.Ala41Thr) single nucleotide variant Inborn genetic diseases [RCV003290680] Chr2:61888387 [GRCh38]
Chr2:62115522 [GRCh37]
Chr2:2p15
uncertain significance
GRCh37/hg19 2p15(chr2:61523951-62262243)x3 copy number gain not provided [RCV001005281] Chr2:61523951..62262243 [GRCh37]
Chr2:2p15
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13
pathogenic
NM_006430.4(CCT4):c.605G>A (p.Ser202Asn) single nucleotide variant Inborn genetic diseases [RCV002973005] Chr2:61877432 [GRCh38]
Chr2:62104567 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.394A>G (p.Ile132Val) single nucleotide variant Inborn genetic diseases [RCV002772553] Chr2:61878997 [GRCh38]
Chr2:62106132 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.71A>T (p.Tyr24Phe) single nucleotide variant Inborn genetic diseases [RCV002734593] Chr2:61888437 [GRCh38]
Chr2:62115572 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.1448G>A (p.Arg483Gln) single nucleotide variant CCT4-related condition [RCV003928933]|Inborn genetic diseases [RCV002738633] Chr2:61872125 [GRCh38]
Chr2:62099260 [GRCh37]
Chr2:2p15
likely benign|uncertain significance
NM_006430.4(CCT4):c.460C>T (p.Pro154Ser) single nucleotide variant Inborn genetic diseases [RCV002782235] Chr2:61878931 [GRCh38]
Chr2:62106066 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.514A>G (p.Asn172Asp) single nucleotide variant Inborn genetic diseases [RCV002744509] Chr2:61878877 [GRCh38]
Chr2:62106012 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.670G>A (p.Val224Met) single nucleotide variant Inborn genetic diseases [RCV002789148] Chr2:61877027 [GRCh38]
Chr2:62104162 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.485C>T (p.Thr162Ile) single nucleotide variant Inborn genetic diseases [RCV002763038] Chr2:61878906 [GRCh38]
Chr2:62106041 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.1531C>T (p.Pro511Ser) single nucleotide variant Inborn genetic diseases [RCV002956318] Chr2:61869514 [GRCh38]
Chr2:62096649 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.1372A>G (p.Met458Val) single nucleotide variant Inborn genetic diseases [RCV002763371] Chr2:61872201 [GRCh38]
Chr2:62099336 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.903G>T (p.Gln301His) single nucleotide variant Inborn genetic diseases [RCV002836047] Chr2:61876109 [GRCh38]
Chr2:62103244 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.386A>G (p.His129Arg) single nucleotide variant Inborn genetic diseases [RCV002807444] Chr2:61879005 [GRCh38]
Chr2:62106140 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.1487G>A (p.Arg496Gln) single nucleotide variant Inborn genetic diseases [RCV002722548] Chr2:61872086 [GRCh38]
Chr2:62099221 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.1313A>G (p.Glu438Gly) single nucleotide variant Inborn genetic diseases [RCV003299631] Chr2:61872260 [GRCh38]
Chr2:62099395 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.1552G>T (p.Ala518Ser) single nucleotide variant Inborn genetic diseases [RCV003173424] Chr2:61869493 [GRCh38]
Chr2:62096628 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.812A>G (p.Gln271Arg) single nucleotide variant Inborn genetic diseases [RCV003378525] Chr2:61876200 [GRCh38]
Chr2:62103335 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.444G>T (p.Leu148Phe) single nucleotide variant Inborn genetic diseases [RCV003344830] Chr2:61878947 [GRCh38]
Chr2:62106082 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.330CAT[1] (p.Ile112del) microsatellite not provided [RCV003429190] Chr2:61880330..61880332 [GRCh38]
Chr2:62107465..62107467 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.892C>T (p.Leu298Phe) single nucleotide variant CCT4-related condition [RCV003412497] Chr2:61876120 [GRCh38]
Chr2:62103255 [GRCh37]
Chr2:2p15
uncertain significance
NM_006430.4(CCT4):c.128-17_128-16dup duplication not provided [RCV003663010] Chr2:61885087..61885088 [GRCh38]
Chr2:62112222..62112223 [GRCh37]
Chr2:2p15
benign
GRCh37/hg19 2p15(chr2:61518864-62195531)x3 copy number gain not specified [RCV003986331] Chr2:61518864..62195531 [GRCh37]
Chr2:2p15
uncertain significance
GRCh37/hg19 2p16.1-15(chr2:61215496-62175386)x3 copy number gain not specified [RCV003986317] Chr2:61215496..62175386 [GRCh37]
Chr2:2p16.1-15
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:809
Count of miRNA genes:465
Interacting mature miRNAs:497
Transcripts:ENST00000394440, ENST00000461370, ENST00000461540, ENST00000538252, ENST00000544079, ENST00000544185
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-195  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,095,602 - 62,095,764UniSTSGRCh37
GRCh37262,095,602 - 62,095,737UniSTSGRCh37
Build 36261,949,106 - 61,949,241RGDNCBI36
Celera261,940,513 - 61,940,675UniSTS
Celera261,940,513 - 61,940,648RGD
Cytogenetic Map2p15UniSTS
HuRef261,835,557 - 61,835,692UniSTS
HuRef261,835,557 - 61,835,719UniSTS
TNG Radiation Hybrid Map239234.0UniSTS
GeneMap99-G3 RH Map22461.0UniSTS
D2S412E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X114,196,144 - 114,196,271UniSTSGRCh37
GRCh37262,095,700 - 62,095,827UniSTSGRCh37
Build 36X114,102,400 - 114,102,527RGDNCBI36
CeleraX114,631,308 - 114,631,435RGD
Celera261,940,611 - 61,940,738UniSTS
Cytogenetic Map2p15UniSTS
HuRef261,835,655 - 61,835,782UniSTS
WI-16954  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,115,141 - 62,115,241UniSTSGRCh37
Build 36261,968,645 - 61,968,745RGDNCBI36
Celera261,960,086 - 61,960,186RGD
Cytogenetic Map2p15UniSTS
HuRef261,855,057 - 61,855,157UniSTS
GeneMap99-GB4 RH Map2189.82UniSTS
Whitehead-RH Map2257.9UniSTS
RH11918  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,095,410 - 62,095,532UniSTSGRCh37
Build 36261,948,914 - 61,949,036RGDNCBI36
Celera261,940,321 - 61,940,443RGD
Cytogenetic Map2p15UniSTS
HuRef261,835,365 - 61,835,487UniSTS
GeneMap99-GB4 RH Map2194.5UniSTS
NCBI RH Map2349.4UniSTS
RH68840  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,098,812 - 62,098,958UniSTSGRCh37
Build 36261,952,316 - 61,952,462RGDNCBI36
Celera261,943,726 - 61,943,872RGD
Cytogenetic Map2p15UniSTS
HuRef261,838,725 - 61,838,871UniSTS
GeneMap99-GB4 RH Map2194.5UniSTS
A009Z10  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,115,156 - 62,115,303UniSTSGRCh37
Build 36261,968,660 - 61,968,807RGDNCBI36
Celera261,960,101 - 61,960,248RGD
Cytogenetic Map2p15UniSTS
HuRef261,855,072 - 61,855,219UniSTS
GeneMap99-GB4 RH Map2194.5UniSTS
G33008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,115,156 - 62,115,303UniSTSGRCh37
Celera261,960,101 - 61,960,248UniSTS
Cytogenetic Map2p15UniSTS
HuRef261,855,072 - 61,855,219UniSTS
RH66235  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37262,095,740 - 62,096,609UniSTSGRCh37
Celera261,940,651 - 61,941,519UniSTS
Cytogenetic Map2p15UniSTS
HuRef261,835,695 - 61,836,563UniSTS
GeneMap99-GB4 RH Map2189.92UniSTS
NCBI RH Map2346.7UniSTS
SHGC-195  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2p15UniSTS
GeneMap99-G3 RH Map22461.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 3 19 3
Medium 2430 2871 1715 615 1889 457 4355 2137 3669 413 1429 1604 171 1204 2788 4
Low 4 117 8 9 57 7 1 57 46 5 5 2 2 1 1 2
Below cutoff 1 2 1 1 1 10 1 4 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001256721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA136129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF026291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI439570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL555753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU128145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM765256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD369623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB461009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000394440   ⟹   ENSP00000377958
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,868,085 - 61,888,656 (-)Ensembl
RefSeq Acc Id: ENST00000461370
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,887,948 - 61,888,458 (-)Ensembl
RefSeq Acc Id: ENST00000461540
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,868,430 - 61,877,026 (-)Ensembl
RefSeq Acc Id: ENST00000544079   ⟹   ENSP00000443061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,868,125 - 61,888,671 (-)Ensembl
RefSeq Acc Id: NM_001256721   ⟹   NP_001243650
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,868,127 - 61,888,671 (-)NCBI
GRCh37262,095,262 - 62,115,806 (-)NCBI
HuRef261,835,217 - 61,855,722 (-)NCBI
CHM1_1262,025,224 - 62,045,751 (-)NCBI
T2T-CHM13v2.0261,874,288 - 61,894,829 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006430   ⟹   NP_006421
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,868,085 - 61,888,656 (-)NCBI
GRCh37262,095,262 - 62,115,806 (-)NCBI
Build 36261,948,766 - 61,969,295 (-)NCBI Archive
HuRef261,835,217 - 61,855,722 (-)NCBI
CHM1_1262,025,224 - 62,045,751 (-)NCBI
T2T-CHM13v2.0261,874,246 - 61,894,814 (-)NCBI
Sequence:
RefSeq Acc Id: NP_006421   ⟸   NM_006430
- Peptide Label: isoform a
- UniProtKB: Q53QP9 (UniProtKB/Swiss-Prot),   O14870 (UniProtKB/Swiss-Prot),   F5H5W3 (UniProtKB/Swiss-Prot),   B7Z8B1 (UniProtKB/Swiss-Prot),   B2R6I3 (UniProtKB/Swiss-Prot),   Q96C51 (UniProtKB/Swiss-Prot),   P50991 (UniProtKB/Swiss-Prot),   A8K3C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243650   ⟸   NM_001256721
- Peptide Label: isoform b
- UniProtKB: A8K3C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000443061   ⟸   ENST00000544079
RefSeq Acc Id: ENSP00000377958   ⟸   ENST00000394440

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50991-F1-model_v2 AlphaFold P50991 1-539 view protein structure

Promoters
RGD ID:6860414
Promoter ID:EPDNEW_H3372
Type:initiation region
Name:CCT4_1
Description:chaperonin containing TCP1 subunit 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,888,656 - 61,888,716EPDNEW
RGD ID:6796957
Promoter ID:HG_KWN:32846
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000325550
Position:
Human AssemblyChrPosition (strand)Source
Build 36261,957,101 - 61,957,601 (-)MPROMDB
RGD ID:6797195
Promoter ID:HG_KWN:32848
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000405571,   OTTHUMT00000325548,   OTTHUMT00000325983
Position:
Human AssemblyChrPosition (strand)Source
Build 36261,969,001 - 61,969,501 (-)MPROMDB
RGD ID:6853414
Promoter ID:EP74532
Type:initiation region
Name:HS_CCT4
Description:Chaperonin containing TCP1, subunit 4 (delta).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36261,969,273 - 61,969,333EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1617 AgrOrtholog
COSMIC CCT4 COSMIC
Ensembl Genes ENSG00000115484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000394440 ENTREZGENE
  ENST00000394440.8 UniProtKB/Swiss-Prot
  ENST00000544079 ENTREZGENE
  ENST00000544079.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.560.10 UniProtKB/Swiss-Prot
  3.30.260.10 UniProtKB/Swiss-Prot
  3.50.7.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroEL-like equatorial domain UniProtKB/TrEMBL
  TCP-1-like chaperonin intermediate domain UniProtKB/TrEMBL
GTEx ENSG00000115484 GTEx
HGNC ID HGNC:1617 ENTREZGENE
Human Proteome Map CCT4 Human Proteome Map
InterPro Chap_CCT_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chaperone_TCP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chaperonin_TCP-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cpn60/GroEL/TCP-1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GROEL-like_equatorial_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10575 UniProtKB/Swiss-Prot
NCBI Gene 10575 ENTREZGENE
OMIM 605142 OMIM
PANTHER CHAPERONIN UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  T-COMPLEX PROTEIN 1 SUBUNIT DELTA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26181 PharmGKB
PRINTS TCOMPLEXTCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TCP1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP GroEL apical domain-like UniProtKB/TrEMBL
  GroEL equatorial domain-like UniProtKB/TrEMBL
  GroEL-intermediate domain like UniProtKB/TrEMBL
  SSF48592 UniProtKB/Swiss-Prot
  SSF52029 UniProtKB/Swiss-Prot
  SSF54849 UniProtKB/Swiss-Prot
UniProt A8K3C3 ENTREZGENE, UniProtKB/TrEMBL
  B2R6I3 ENTREZGENE
  B7Z8B1 ENTREZGENE
  F5H5W3 ENTREZGENE
  O14870 ENTREZGENE
  P50991 ENTREZGENE
  Q53QP9 ENTREZGENE
  Q96C51 ENTREZGENE
  TCPD_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R6I3 UniProtKB/Swiss-Prot
  B7Z8B1 UniProtKB/Swiss-Prot
  F5H5W3 UniProtKB/Swiss-Prot
  O14870 UniProtKB/Swiss-Prot
  Q53QP9 UniProtKB/Swiss-Prot
  Q96C51 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-12 CCT4  chaperonin containing TCP1 subunit 4  CCT4  chaperonin containing TCP1, subunit 4 (delta)  Symbol and/or name change 5135510 APPROVED