Gene: TNFSF13B (tumor necrosis factor (ligand) superfamily, member 13b)
Homo sapiens
Symbol:
TNFSF13B
Name:
tumor necrosis factor (ligand) superfamily, member 13b
Description:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
ApoL related ligand TALL-1; b lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLYS; CD257; delta BAFF; Delta4 BAFF; dendritic cell-derived TNF-like molecule; DTL; OTTHUMP00000018691; TALL-1; TALL1; THANK; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF20; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4
Orthologs:
Mus musculus : Tnfsf13b
(tumor necrosis factor (ligand) superfamily, member 13b)
MGI
Tnfsf13b
(tumor necrosis factor (ligand) superfamily, member 13b)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 13 89,850,057 - 89,884,156 + NCBI Human Genome Assembly HuRef 13 89,512,942 - 89,552,797 + NCBI Human Genome Assembly GRCh37 13 108,921,977 - 108,960,832 + NCBI Human Genome Assembly Build 36 13 107,719,978 - 107,757,366 + NCBI Human Cytogenetic Map 13 q32-q34 NCBI Human Genome Assembly 13 107,719,977 - 107,757,366 NCBI
Model
Gene Ontology Annotations
Biological Process B cell costimulation IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 B cell homeostasis IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell proliferation TAS 2290271 PMID:10908663 PINC PMID:10908663 immune response IEA InterPro:IPR006052 2290271 GO_REF:0000002 InterPro GO_REF:0000002 immunoglobulin secretion IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of B cell proliferation IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of cell proliferation TAS 2290271 PMID:10359578 PINC PMID:10359578 positive regulation of germinal center formation IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of T cell proliferation IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 signal transduction TAS 2290271 PMID:10908663 PINC PMID:10908663 T cell costimulation IEA Ensembl:ENSMUSP00000033892 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019
1358855 MULTSCL32_H Multiple sclerosis susceptibility QTL 32 (human) 1.1 Multiple sclerosis susceptibility 13 39032331 112795540 Human 1559260 SCL81_H Serum cholesterol level QTL 81 (human) 5.22 Lipid level LDL cholesterol 13 83956912 109956912 Human 2292950 PRSTS143_H Prostate tumor susceptibility QTL 143 (human) 6.12 .000015 Prostate tumor susceptibility 13 84550447 110550447 Human 2314572 GLUCO40_H Glucose level QTL 40 (human) 2.08 .00098 Glucose level 13 84951940 110951940 Human 2289426 BW213_H Body weight QTL 213 (human) 2.78 .0002 Body weight BMI 13 84960462 110960462 Human 2289433 BW340_H Body weight QTL 340 (human) 3.11 Body morphometry waist circumference 13 84960462 110960462 Human 1643561 GLUCO30_H Glucose level QTL 30 (human) .038 Glucose level non-insulin-dependent 13 86631452 112631452 Human 1643069 BW121_H Body Weight QTL 121 (human) 2.67 .00023 Body weight 13 88504048 114504048 Human 1643276 BW200_H Body weight QTL 200 (human) 2.82 .0002 Body weight BMI 13 88504048 114504048 Human 1643297 BW204_H Body weight QTL 204 (human) 1.8 .002 Body morphometry waist circumference 13 88504048 114504048 Human 2289462 SADIPOQ15_H Serum adiponectin level QTL 15 (human) 2.41 Hormone level adiponectin level 13 90976453 115092803 Human 1576335 MYI15_H Myocardial infarction susceptibility QTL 15 (human) 3.61 Myocardial infarction susceptibility early-onset 13 94889046 115092803 Human 1576331 MYI7_H Myocardial infarction susceptibility QTL 7 (human) 3.86 Myocardial infarction susceptibility early-onset 13 94889046 115092803 Human 1643588 GLUCO4_H Glucose level QTL 4 (human) 4.6 Glucose level fasting 13 99053594 112795540 Human 2314779 GLUCO115_H Glucose level QTL 115 (human) 1.86 Glucose level 13 99795486 115092803 Human 2314783 GLUCO114_H Glucose level QTL 114 (human) 1.35 Glucose level 13 99795486 115092803 Human 2301160 PRSTS397_H Prostate tumor susceptibility QTL 397 (human) Prostate tumor susceptibility 13 99795486 115092803 Human 1559241 SCL77_H Serum cholesterol level QTL 77 (human) 2.68 Lipid level triglyceride 13 100094527 115092803 Human 1559258 SCL74_H Serum cholesterol level QTL 74 (human) 2 Lipid level triglyceride 13 100094527 115092803 Human
Gene Ontology Annotations
