GH2 (growth hormone 2) - Rat Genome Database

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Gene: GH2 (growth hormone 2) Homo sapiens
Analyze
No known orthologs.
Symbol: GH2
Name: growth hormone 2
RGD ID: 1344971
HGNC Page HGNC:4262
Description: Predicted to enable growth factor activity; growth hormone receptor binding activity; and hormone activity. Predicted to be involved in several processes, including growth hormone receptor signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in endosome lumen and extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GH-V; GHB2; GHL; GHV; growth hormone B2; growth hormone variant; hGH-V; placenta-specific growth hormone; placental-specific growth hormone
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: See ClinVar data
Candidate Gene For: GLUCO234_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,880,215 - 63,881,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,880,215 - 63,881,944 (-)EnsemblGRCh38hg38GRCh38
GRCh371761,957,575 - 61,959,304 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,311,304 - 59,312,955 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,311,305 - 59,312,955NCBI
Celera1756,345,654 - 56,347,305 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,325,225 - 57,326,955 (-)NCBIHuRef
CHM1_11762,021,912 - 62,023,642 (-)NCBICHM1_1
T2T-CHM13v2.01764,750,989 - 64,752,719 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1378436   PMID:1955498   PMID:1980158   PMID:2196278   PMID:2460050   PMID:2744760   PMID:3379057   PMID:6262212   PMID:6286668   PMID:6306568   PMID:7072716   PMID:7169009  
PMID:7384802   PMID:8943276   PMID:9367422   PMID:9709963   PMID:9820620   PMID:11994274   PMID:12213191   PMID:12477932   PMID:12946357   PMID:14595650   PMID:15489334   PMID:15531513  
PMID:15563602   PMID:15718272   PMID:16344560   PMID:17701665   PMID:18356738   PMID:18976975   PMID:19844941   PMID:20005926   PMID:20403354   PMID:21873635   PMID:22363400   PMID:22387044  
PMID:22489624   PMID:23178941   PMID:24035309   PMID:26186194   PMID:26589570   PMID:26697363   PMID:26862561   PMID:28514442   PMID:33961781   PMID:36233301   PMID:37759746  


Genomics

Variants

.
Variants in GH2
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh37/hg19 17q23-24(chr17:59209629-64222315)x3 copy number gain See cases [RCV000052485] Chr17:59209629..64222315 [GRCh37]
Chr17:56564411..61652777 [NCBI36]
Chr17:17q23-24		 pathogenic
NM_002059.4(GH2):c.354C>T (p.Leu118=) single nucleotide variant Malignant melanoma [RCV000071602] Chr17:63880874 [GRCh38]
Chr17:61958234 [GRCh37]
Chr17:59311966 [NCBI36]
Chr17:17q23.3		 not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3		 pathogenic
GRCh37/hg19 17q23.3(chr17:61940902-61973673)x1 copy number loss See cases [RCV000449112] Chr17:61940902..61973673 [GRCh37]
Chr17:17q23.3		 likely benign
GRCh37/hg19 17q23.3(chr17:61940902-61986943)x1 copy number loss See cases [RCV000448892] Chr17:61940902..61986943 [GRCh37]
Chr17:17q23.3		 likely benign
GRCh37/hg19 17q23.3(chr17:61949400-61973673)x3 copy number gain See cases [RCV000448832] Chr17:61949400..61973673 [GRCh37]
Chr17:17q23.3		 likely benign
GRCh37/hg19 17q23.3(chr17:61937184-61973673)x1 copy number loss See cases [RCV000448565] Chr17:61937184..61973673 [GRCh37]
Chr17:17q23.3		 likely benign
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q23.2-24.2(chr17:59597348-64886364)x3 copy number gain not provided [RCV000752158] Chr17:59597348..64886364 [GRCh37]
Chr17:17q23.2-24.2		 pathogenic
GRCh37/hg19 17q23.3(chr17:61915326-61983601)x1 copy number loss not provided [RCV000752166] Chr17:61915326..61983601 [GRCh37]
Chr17:17q23.3		 benign
GRCh37/hg19 17q23.3(chr17:61947754-61983601)x1 copy number loss not provided [RCV000752167] Chr17:61947754..61983601 [GRCh37]
Chr17:17q23.3		 benign
GRCh37/hg19 17q23.3(chr17:61954471-61987779)x1 copy number loss not provided [RCV000752168] Chr17:61954471..61987779 [GRCh37]
Chr17:17q23.3		 benign
GRCh37/hg19 17q23.3(chr17:61957633-61983601)x0 copy number loss not provided [RCV000752169] Chr17:61957633..61983601 [GRCh37]
Chr17:17q23.3		 benign
GRCh37/hg19 17q23.3(chr17:61957633-61986027)x1 copy number loss not provided [RCV000752170] Chr17:61957633..61986027 [GRCh37]
Chr17:17q23.3		 benign
GRCh37/hg19 17q22-24.2(chr17:57357088-66306668) copy number gain not provided [RCV000767764] Chr17:57357088..66306668 [GRCh37]
Chr17:17q22-24.2		 pathogenic
GRCh37/hg19 17q23.1-24.2(chr17:57869604-67078443)x3 copy number gain not provided [RCV000845965] Chr17:57869604..67078443 [GRCh37]
Chr17:17q23.1-24.2		 pathogenic
GRCh37/hg19 17q23.3(chr17:61838634-62465444)x4 copy number gain not provided [RCV002473722] Chr17:61838634..62465444 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.350A>G (p.Gln117Arg) single nucleotide variant Inborn genetic diseases [RCV002907494] Chr17:63880878 [GRCh38]
Chr17:61958238 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.457-66T>C single nucleotide variant Inborn genetic diseases [RCV002887844] Chr17:63880584 [GRCh38]
Chr17:61957944 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.360G>C (p.Arg120Ser) single nucleotide variant Inborn genetic diseases [RCV002707284] Chr17:63880868 [GRCh38]
Chr17:61958228 [GRCh37]
Chr17:17q23.3		 likely benign
NM_002059.5(GH2):c.51C>G (p.Cys17Trp) single nucleotide variant Inborn genetic diseases [RCV002699346] Chr17:63881479 [GRCh38]
Chr17:61958839 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.498T>G (p.Asn166Lys) single nucleotide variant Inborn genetic diseases [RCV002987350] Chr17:63880477 [GRCh38]
Chr17:61957837 [GRCh37]
Chr17:17q23.3		 likely benign
NM_002059.5(GH2):c.502T>A (p.Ser168Thr) single nucleotide variant Inborn genetic diseases [RCV002984767] Chr17:63880473 [GRCh38]
Chr17:61957833 [GRCh37]
Chr17:17q23.3		 likely benign
NM_002059.5(GH2):c.7G>C (p.Ala3Pro) single nucleotide variant Inborn genetic diseases [RCV002855135] Chr17:63881795 [GRCh38]
Chr17:61959155 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.386A>T (p.Tyr129Phe) single nucleotide variant Inborn genetic diseases [RCV002812458] Chr17:63880842 [GRCh38]
Chr17:61958202 [GRCh37]
Chr17:17q23.3		 likely benign
NM_002059.5(GH2):c.352C>T (p.Leu118Phe) single nucleotide variant Inborn genetic diseases [RCV002679712] Chr17:63880876 [GRCh38]
Chr17:61958236 [GRCh37]
Chr17:17q23.3		 likely benign
NM_002059.5(GH2):c.293A>G (p.Asn98Ser) single nucleotide variant Inborn genetic diseases [RCV002680269] Chr17:63880935 [GRCh38]
Chr17:61958295 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.456+49A>G single nucleotide variant Inborn genetic diseases [RCV003257703] Chr17:63880723 [GRCh38]
Chr17:61958083 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.512A>T (p.Lys171Met) single nucleotide variant Inborn genetic diseases [RCV003285336] Chr17:63880463 [GRCh38]
Chr17:61957823 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.328C>G (p.Gln110Glu) single nucleotide variant Inborn genetic diseases [RCV003264711] Chr17:63880900 [GRCh38]
Chr17:61958260 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.452T>A (p.Met151Lys) single nucleotide variant Inborn genetic diseases [RCV003359535] Chr17:63880776 [GRCh38]
Chr17:61958136 [GRCh37]
Chr17:17q23.3		 uncertain significance
NM_002059.5(GH2):c.474C>T (p.Ser158=) single nucleotide variant Inborn genetic diseases [RCV003385043] Chr17:63880501 [GRCh38]
Chr17:61957861 [GRCh37]
Chr17:17q23.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1095
Count of miRNA genes:513
Interacting mature miRNAs:574
Transcripts:ENST00000332800, ENST00000423893, ENST00000449787, ENST00000456543
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH66837  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371761,957,611 - 61,957,754UniSTSGRCh37
GRCh371761,949,413 - 61,949,559UniSTSGRCh37
Build 361759,303,145 - 59,303,291RGDNCBI36
Celera1756,337,526 - 56,337,672RGD
Celera1756,345,693 - 56,345,836UniSTS
Cytogenetic Map17q24.2UniSTS
HuRef1757,317,491 - 57,317,637UniSTS
HuRef1757,325,264 - 57,325,407UniSTS
GeneMap99-GB4 RH Map17405.21UniSTS
NCBI RH Map17675.8UniSTS
STS-J03756  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q24.2UniSTS
GeneMap99-GB4 RH Map17405.21UniSTS
NCBI RH Map17675.8UniSTS
GHI  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371761,958,200 - 61,958,845UniSTSGRCh37
GRCh371761,995,188 - 61,995,832UniSTSGRCh37
Celera1756,346,282 - 56,346,927UniSTS
Celera1756,383,227 - 56,383,871UniSTS
HuRef1757,362,880 - 57,363,524UniSTS
HuRef1757,325,853 - 57,326,498UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 9 9
Medium 1 1 167 1 1 5 1 165 1 3 1 3 2
Low 4 103 2 23 2 176 4 102 3 159 13 2 2 3
Below cutoff 322 366 202 79 262 55 541 271 354 33 388 204 25 207 334

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC040958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF006060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF006061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU139016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF528273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU421715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM644137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000332800   ⟹   ENSP00000333157
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1763,880,224 - 63,881,935 (-)Ensembl
RefSeq Acc Id: ENST00000423893   ⟹   ENSP00000409294
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1763,880,215 - 63,881,944 (-)Ensembl
RefSeq Acc Id: ENST00000449787   ⟹   ENSP00000410618
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1763,880,218 - 63,881,842 (-)Ensembl
RefSeq Acc Id: ENST00000456543   ⟹   ENSP00000394122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1763,880,218 - 63,881,842 (-)Ensembl
RefSeq Acc Id: ENST00000622506   ⟹   ENSP00000481086
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1763,880,215 - 63,881,863 (-)Ensembl
RefSeq Acc Id: NM_002059   ⟹   NP_002050
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381763,880,215 - 63,881,944 (-)NCBI
GRCh371761,957,572 - 61,960,039 (-)NCBI
Build 361759,311,308 - 59,312,955 (-)NCBI Archive
HuRef1757,325,225 - 57,326,955 (-)NCBI
CHM1_11762,021,912 - 62,023,642 (-)NCBI
T2T-CHM13v2.01764,750,989 - 64,752,719 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022556   ⟹   NP_072050
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381763,880,215 - 63,881,944 (-)NCBI
GRCh371761,957,572 - 61,960,039 (-)NCBI
Build 361759,311,308 - 59,312,955 (-)NCBI Archive
HuRef1757,325,225 - 57,326,955 (-)NCBI
CHM1_11762,021,912 - 62,023,642 (-)NCBI
T2T-CHM13v2.01764,750,989 - 64,752,719 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022557   ⟹   NP_072051
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381763,880,215 - 63,881,944 (-)NCBI
GRCh371761,957,572 - 61,960,039 (-)NCBI
Build 361759,311,304 - 59,312,955 (-)NCBI Archive
HuRef1757,325,225 - 57,326,955 (-)NCBI
CHM1_11762,021,912 - 62,023,642 (-)NCBI
T2T-CHM13v2.01764,750,989 - 64,752,719 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022558   ⟹   NP_072052
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381763,880,215 - 63,881,944 (-)NCBI
GRCh371761,957,572 - 61,960,039 (-)NCBI
Build 361759,311,306 - 59,312,955 (-)NCBI Archive
HuRef1757,325,225 - 57,326,955 (-)NCBI
CHM1_11762,021,912 - 62,023,642 (-)NCBI
T2T-CHM13v2.01764,750,989 - 64,752,719 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_002050 (Get FASTA)   NCBI Sequence Viewer  
  NP_072050 (Get FASTA)   NCBI Sequence Viewer  
  NP_072051 (Get FASTA)   NCBI Sequence Viewer  
  NP_072052 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35891 (Get FASTA)   NCBI Sequence Viewer  
  AAA52552 (Get FASTA)   NCBI Sequence Viewer  
  AAA98619 (Get FASTA)   NCBI Sequence Viewer  
  AAB59547 (Get FASTA)   NCBI Sequence Viewer  
  AAB59548 (Get FASTA)   NCBI Sequence Viewer  
  AAB71828 (Get FASTA)   NCBI Sequence Viewer  
  AAB71829 (Get FASTA)   NCBI Sequence Viewer  
  AAH20760 (Get FASTA)   NCBI Sequence Viewer  
  ABZ88719 (Get FASTA)   NCBI Sequence Viewer  
  ABZ88720 (Get FASTA)   NCBI Sequence Viewer  
  ABZ88721 (Get FASTA)   NCBI Sequence Viewer  
  ABZ88722 (Get FASTA)   NCBI Sequence Viewer  
  BAG35127 (Get FASTA)   NCBI Sequence Viewer  
  BAG70146 (Get FASTA)   NCBI Sequence Viewer  
  BAG70291 (Get FASTA)   NCBI Sequence Viewer  
  CAG46700 (Get FASTA)   NCBI Sequence Viewer  
  CAG46722 (Get FASTA)   NCBI Sequence Viewer  
  CDW51384 (Get FASTA)   NCBI Sequence Viewer  
  EAW94238 (Get FASTA)   NCBI Sequence Viewer  
  EAW94248 (Get FASTA)   NCBI Sequence Viewer  
  EAW94252 (Get FASTA)   NCBI Sequence Viewer  
  EAW94258 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000333157
  ENSP00000333157.7
  ENSP00000394122
  ENSP00000394122.2
  ENSP00000409294
  ENSP00000409294.2
  ENSP00000410618
  ENSP00000410618.2
  ENSP00000481086.1
GenBank Protein P01242 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_072051   ⟸   NM_022557
- Peptide Label: isoform 2 precursor
- UniProtKB: P01242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_072052   ⟸   NM_022558
- Peptide Label: isoform 3 precursor
- UniProtKB: P01242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_072050   ⟸   NM_022556
- Peptide Label: isoform 4 precursor
- UniProtKB: Q6FH32 (UniProtKB/TrEMBL),   Q6FH54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002050   ⟸   NM_002059
- Peptide Label: isoform 1 precursor
- UniProtKB: O14644 (UniProtKB/Swiss-Prot),   O14643 (UniProtKB/Swiss-Prot),   B1A4H7 (UniProtKB/Swiss-Prot),   B1A4H5 (UniProtKB/Swiss-Prot),   P09587 (UniProtKB/Swiss-Prot),   P01242 (UniProtKB/Swiss-Prot),   A0A0M6L0J9 (UniProtKB/TrEMBL),   Q6FH32 (UniProtKB/TrEMBL),   Q6FH54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000409294   ⟸   ENST00000423893
RefSeq Acc Id: ENSP00000333157   ⟸   ENST00000332800
RefSeq Acc Id: ENSP00000481086   ⟸   ENST00000622506
RefSeq Acc Id: ENSP00000394122   ⟸   ENST00000456543
RefSeq Acc Id: ENSP00000410618   ⟸   ENST00000449787

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01242-F1-model_v2 AlphaFold P01242 1-217 view protein structure

Promoters
RGD ID:7235997
Promoter ID:EPDNEW_H23744
Type:multiple initiation site
Name:GH2_1
Description:growth hormone 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381763,881,863 - 63,881,923EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4262 AgrOrtholog
COSMIC GH2 COSMIC
Ensembl Genes ENSG00000136487 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000332800 ENTREZGENE
  ENST00000332800.7 UniProtKB/Swiss-Prot
  ENST00000423893 ENTREZGENE
  ENST00000423893.7 UniProtKB/Swiss-Prot
  ENST00000449787 ENTREZGENE
  ENST00000449787.6 UniProtKB/Swiss-Prot
  ENST00000456543 ENTREZGENE
  ENST00000456543.6 UniProtKB/Swiss-Prot
  ENST00000622506.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000136487 GTEx
HGNC ID HGNC:4262 ENTREZGENE
Human Proteome Map GH2 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2689 ENTREZGENE
OMIM 139240 OMIM
PANTHER GROWTH HORMONE VARIANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28672 PharmGKB
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WXJ5_HUMAN UniProtKB/TrEMBL
  A0A0M6L0J9 ENTREZGENE, UniProtKB/TrEMBL
  B1A4H5 ENTREZGENE
  B1A4H7 ENTREZGENE
  O14643 ENTREZGENE
  O14644 ENTREZGENE
  P01242 ENTREZGENE
  P09587 ENTREZGENE
  Q6FH32 ENTREZGENE, UniProtKB/TrEMBL
  Q6FH54 ENTREZGENE, UniProtKB/TrEMBL
  SOM2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B1A4H5 UniProtKB/Swiss-Prot
  B1A4H7 UniProtKB/Swiss-Prot
  O14643 UniProtKB/Swiss-Prot
  O14644 UniProtKB/Swiss-Prot
  P09587 UniProtKB/Swiss-Prot