Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nrk (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NRK mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NRK mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | increases expression | ISO | Nrk (Mus musculus) | 6480464 | bisphenol S results in increased expression of NRK mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of NRK gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [bisphenol S co-treated with Tretinoin] results in decreased expression of NRK mRNA | CTD | PMID:30951980 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of NRK mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [bisphenol S co-treated with Tretinoin] results in decreased expression of NRK mRNA | CTD | PMID:30951980 | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of NRK mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of NRK mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases mutagenesis | EXP | | 6480464 | Benzo(a)pyrene results in increased mutagenesis of NRK gene | CTD | PMID:25435355 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of NRK 5' UTR and Benzo(a)pyrene affects the methylation of NRK promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of NRK mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NRK gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of NRK mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | ISO | Nrk (Mus musculus) | 6480464 | bisphenol A results in increased expression of NRK mRNA | CTD | PMID:30951980 and PMID:34585602 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NRK mRNA | CTD | PMID:29275510 | bisphenol A | decreases methylation | ISO | Nrk (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of NRK promoter | CTD | PMID:27312807 | bisphenol A | affects methylation | ISO | Nrk (Mus musculus) | 6480464 | bisphenol A affects the methylation of NRK promoter | CTD | PMID:27334623 | bisphenol F | increases expression | ISO | Nrk (Mus musculus) | 6480464 | bisphenol F results in increased expression of NRK mRNA | CTD | PMID:30951980 | chlordecone | increases expression | ISO | Nrk (Mus musculus) | 6480464 | Chlordecone results in increased expression of NRK mRNA | CTD | PMID:33711761 | dextran sulfate | decreases expression | ISO | Nrk (Mus musculus) | 6480464 | Dextran Sulfate results in decreased expression of NRK mRNA | CTD | PMID:35093514 | dibutyl phthalate | decreases expression | ISO | Nrk (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of NRK mRNA | CTD | PMID:21266533 | dioxygen | increases expression | EXP | | 6480464 | Oxygen deficiency results in increased expression of NRK mRNA | CTD | PMID:24236059 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | endosulfan | decreases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of NRK mRNA | CTD | PMID:29391264 | entinostat | increases expression | EXP | | 6480464 | entinostat results in increased expression of NRK mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRK mRNA | CTD | PMID:27188386 | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NRK gene | CTD | PMID:31601247 | geldanamycin | increases expression | EXP | | 6480464 | geldanamycin results in increased expression of NRK mRNA | CTD | PMID:26705709 | gentamycin | decreases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of NRK mRNA | CTD | PMID:33387578 | isoflurane | increases methylation | ISO | Nrk (Mus musculus) | 6480464 | Isoflurane results in increased methylation of NRK mRNA | CTD | PMID:35249202 | lead diacetate | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of NRK intron | CTD | PMID:33445541 | lead(0) | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of NRK intron | CTD | PMID:33445541 | mercury dibromide | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRK mRNA | CTD | PMID:27188386 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of NRK mRNA | CTD | PMID:25583101 | panobinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRK mRNA | CTD | PMID:27188386 | paracetamol | decreases expression | ISO | Nrk (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of NRK mRNA | CTD | PMID:33387578 | PCB138 | multiple interactions | ISO | Nrk (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | phenylmercury acetate | increases expression | EXP | | 6480464 | Phenylmercuric Acetate results in increased expression of NRK mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRK mRNA | CTD | PMID:27188386 | potassium chromate | increases expression | EXP | | 6480464 | potassium chromate(VI) results in increased expression of NRK mRNA | CTD | PMID:22714537 | potassium dichromate | increases expression | EXP | | 6480464 | Potassium Dichromate results in increased expression of NRK protein | CTD | PMID:23718831 | pyrogallol | decreases expression | ISO | Nrk (Mus musculus) | 6480464 | Pyrogallol results in decreased expression of NRK mRNA | CTD | PMID:20362636 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sevoflurane | increases methylation | ISO | Nrk (Mus musculus) | 6480464 | Sevoflurane results in increased methylation of NRK mRNA | CTD | PMID:35249202 | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of NRK mRNA | CTD | PMID:31533062 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of NRK mRNA | CTD | PMID:24935251 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of NRK gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | Nrk (Mus musculus) | 6480464 | Valproic Acid results in increased expression of NRK mRNA | CTD | PMID:24896083 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of NRK mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NRK mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
Imported Annotations - PID (archival)
Phenotype Annotations Click to see Annotation Detail View
Imported Human Phenotype Annotations - ClinVar
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Molecular Function
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Phenotype Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | GOAs Human GO annotations | GOA_HUMAN data from the GO Consortium |
| 2. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 3. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:11076863 | PMID:11230166 | PMID:12477932 | PMID:12837278 | PMID:14702039 | PMID:15489334 | PMID:15489336 | PMID:15772651 | PMID:16381901 | PMID:21873635 | PMID:27634343 | PMID:30639242 |
| PMID:31741433 | PMID:31797533 | PMID:32162334 | PMID:33387038 | PMID:36736316 | PMID:38459501 |
Genomics
Comparative Map Data
| NRK (Homo sapiens - human) |
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| Nrk (Mus musculus - house mouse) |
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| Nrk (Rattus norvegicus - Norway rat) |
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| Nrk (Chinchilla lanigera - long-tailed chinchilla) |
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| NRK (Pan paniscus - bonobo/pygmy chimpanzee) |
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| NRK (Canis lupus familiaris - dog) |
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| Nrk (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| NRK (Sus scrofa - pig) |
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| NRK (Chlorocebus sabaeus - green monkey) |
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| Nrk (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in NRK
66 total Variants 
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