BRCC3 (BRCA1/BRCA2-containing complex, subunit 3)

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Keyword

Gene: BRCC3 (BRCA1/BRCA2-containing complex, subunit 3) Homo sapiens

Symbol:

BRCC3

Name:

BRCA1/BRCA2-containing complex, subunit 3

Description:

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCC36; BRISC complex subunit BRCC36; C6.1A; c6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36; OTTHUMP00000024245; OTTHUMP00000024246; OTTHUMP00000196187; OTTHUMP00000196188; RP11-143H17.2

Orthologs:

Mus musculus : Brcc3 (BRCA1/BRCA2-containing complex, subunit 3) MGI
Rattus norvegicus : Brcc3 (BRCA1/BRCA2-containing complex, subunit 3)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	X	154,168,478 - 154,220,133	+	NCBI
Human Genome Assembly HuRef	X	142,845,949 - 142,896,583	+	NCBI
Human Genome Assembly GRCh37	X	154,299,695 - 154,351,349	+	NCBI
Human Genome Assembly Build 36	X	153,952,904 - 154,004,543	+	NCBI
Human Cytogenetic Map	X	q28		NCBI
Human Genome Assembly	X	153,863,504 - 153,915,052		NCBI