Gene: GNA11 (guanine nucleotide binding protein (G protein), alpha 11 (Gq class))
Homo sapiens |
| Symbol: |
GNA11
|
| Name: |
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
|
| Description: |
ENCODES a protein that exhibits G-protein beta/gamma-subunit complex binding (inferred); G-protein coupled receptor binding (inferred); GTP binding (inferred); INVOLVED IN blood coagulation (inferred); developmental pigmentation (inferred); G-protein coupled receptor signaling pathway (inferred); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; sphingosine 1-phosphate signaling pathway; FOUND IN cytoplasm (inferred); plasma membrane (inferred); INTERACTS WITH arsenic atom; benzo[a]pyrene; diarsenic trioxide |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
g alpha-11; G-protein subunit alpha-11; GNA-11; guanine nucleotide-binding protein G(y) subunit alpha; guanine nucleotide-binding protein subunit alpha-11; guanine nucleotide-binding protein, Gq class, GNA11
|
| Orthologs: |
Mus musculus : Gna11
(guanine nucleotide binding protein, alpha 11)
MGI
Rattus norvegicus : Gna11
(guanine nucleotide binding protein, alpha 11)
|
| Latest Assembly: |
Human Genome Assembly GRCh37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Human Alternate Assembly CHM1_1 | 19 | 3,020,146 - 3,047,070 | + | NCBI | Human Genome Assembly HuRef | 19 | 2,861,199 - 2,888,094 | + | NCBI | Human Genome Assembly GRCh37 | 19 | 3,094,408 - 3,121,468 | + | NCBI | Human Genome Assembly Build 36 | 19 | 3,045,408 - 3,072,468 | + | NCBI | Human Cytogenetic Map | 19 | p13.3 | | NCBI | Human Genome Assembly | 19 | 3,045,529 - 3,072,452 | | NCBI |
|
| Model |
|
|
 Gene Ontology Annotations
Biological Process
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | | IBA | PANTHER:PTN000026392 | 2290271 | GO_REF:0000033 | RefGenome | GO_REF:0000033 | | blood coagulation | | TAS | | 2290271 | Reactome:REACT_604 | Reactome | Reactome:REACT_604 | | developmental pigmentation | | IEA | Ensembl:ENSMUSP00000043190 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | G-protein coupled receptor signaling pathway | | IEA | InterPro:IPR000654|InterPro:IPR001019 | 2290271 | GO_REF:0000002 | InterPro | GO_REF:0000002 | | heart development | | IEA | Ensembl:ENSMUSP00000043190 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | phospholipase C-activating dopamine receptor signaling pathway | | IBA | PANTHER:PTN000026396 | 2290271 | GO_REF:0000033 | RefGenome | GO_REF:0000033 | | platelet activation | | TAS | | 2290271 | Reactome:REACT_798 | Reactome | Reactome:REACT_798 | | regulation of action potential | | IBA | PANTHER:PTN000026401 | 2290271 | GO_REF:0000033 | RefGenome | GO_REF:0000033 | | regulation of melanocyte differentiation | | IEA | Ensembl:ENSMUSP00000043190 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | signal transduction | | TAS | | 2290271 | PMID:8530500 | PINC | PMID:8530500 | | skeletal system development | | IEA | Ensembl:ENSMUSP00000043190 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | |
| 1300034 | BP50_H | Blood pressure QTL 50 (human) | 2.1 | .00094 | Blood pressure | systolic | 19 | 1 | 11244506 | Human |
| 2293432 | PRSTS269_H | Prostate tumor susceptibility QTL 269 (human) | | | Prostate tumor susceptibility | | 19 | 1 | 15567316 | Human |
| 2293449 | PRSTS270_H | Prostate tumor susceptibility QTL 270 (human) | | | Prostate tumor susceptibility | | 19 | 1 | 15567316 | Human |
| 1298499 | UAE1_H | Urinary albumin excretion QTL 1 (human) | 2.73 | .0009 | Urinary albumin excretion | urine albumin:creatinine ratio (ACR) | 19 | 1 | 16075900 | Human |
| 1559404 | SCL117_H | Serum cholesterol level QTL 117 (human) | 2.05 | | Lipid level | triglyceride-HDL ratio | 19 | 1 | 16140092 | Human |
| 2301152 | PRSTS373_H | Prostate tumor susceptibility QTL 373 (human) | 2.94 | | Prostate tumor susceptibility | | 19 | 1 | 16314463 | Human |
| 2301163 | PRSTS377_H | Prostate tumor susceptibility QTL 377 (human) | 1.59 | | Prostate tumor susceptibility | | 19 | 1 | 16314463 | Human |
| 2301168 | PRSTS378_H | Prostate tumor susceptibility QTL 378 (human) | 1.09 | | Prostate tumor susceptibility | | 19 | 1 | 16314463 | Human |
| 2301170 | PRSTS375_H | Prostate tumor susceptibility QTL 375 (human) | 1.87 | | Prostate tumor susceptibility | | 19 | 1 | 16314463 | Human |
| 2300113 | PRSTS337_H | Prostate tumor susceptibility QTL 337 (human) | | | Prostate tumor susceptibility | | 19 | 1 | 17392514 | Human |
| 1559400 | SCL97_H | Serum cholesterol level QTL97 (human) | 3.89 | .00002 | Lipid level | total cholesterol | 19 | 1 | 19113369 | Human |
| 2314744 | GLUCO92_H | Glucose level QTL 92 (human) | .86 | .005 | Glucose level | non-insulin dependent | 19 | 1 | 22178483 | Human |
| 1643248 | BW138_H | Body weight QTL 138 (human) | 1.47 | | Body weight | | 19 | 1 | 22804918 | Human |
| 1559347 | SCL92_H | Serum cholesterol level QTL 92 (human) | 2.15 | .0008 | Lipid level | LDL cholesterol | 19 | 1 | 25712901 | Human |
| 2316728 | GLUCO279_H | Glucose level QTL 279 (human) | 1.26 | .01358 | Glucose level | | 19 | 1 | 25712901 | Human |
| 2301145 | PRSTS371_H | Prostate tumor susceptibility QTL 371 (human) | 2.91 | .0001 | Prostate tumor susceptibility | | 19 | 1 | 31914947 | Human |
| 1298476 | BP3_H | Blood pressure QTL 3 (human) | 2.4 | | Blood pressure | systolic | 19 | 38318 | 6113482 | Human |
| 1331639 | COPD3_H | Chronic obstructive pulmonary disease QTL 3 (human) | 1.54 | | Chronic airflow obstruction | FEV1 <80% predicted and FEV/FVC<90% predicted | 19 | 2682318 | 28682318 | Human |