Or4k15 (olfactory receptor family 4 subfamily K member 15) - Rat Genome Database

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Gene: Or4k15 (olfactory receptor family 4 subfamily K member 15) Rattus norvegicus
Analyze
Symbol: Or4k15
Name: olfactory receptor family 4 subfamily K member 15
RGD ID: 1334431
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR4K15 (olfactory receptor family 4 subfamily K member 15); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1627; olfactory receptor gene Olr1627; olfactory receptor Olr1627; Olr1627
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,752,883 - 25,753,857 (+)NCBIGRCr8
mRatBN7.21523,273,303 - 23,274,277 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,270,833 - 23,278,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,050,576 - 26,051,550 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,011,896 - 27,012,870 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,259,126 - 25,260,100 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01526,887,767 - 26,888,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1526,887,767 - 26,888,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01530,813,946 - 30,814,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,504,566 - 26,505,540 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,520,265 - 26,521,240 (+)NCBI
Celera1523,624,939 - 23,625,913 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or4k15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,752,883 - 25,753,857 (+)NCBIGRCr8
mRatBN7.21523,273,303 - 23,274,277 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,270,833 - 23,278,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,050,576 - 26,051,550 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,011,896 - 27,012,870 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,259,126 - 25,260,100 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01526,887,767 - 26,888,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1526,887,767 - 26,888,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01530,813,946 - 30,814,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,504,566 - 26,505,540 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,520,265 - 26,521,240 (+)NCBI
Celera1523,624,939 - 23,625,913 (+)NCBICelera
Cytogenetic Map15p14NCBI
OR4K15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381419,975,591 - 19,976,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1419,975,591 - 19,976,565 (+)EnsemblGRCh38hg38GRCh38
GRCh371420,443,750 - 20,444,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,513,518 - 19,514,564 (+)NCBINCBI36Build 36hg18NCBI36
Build 341419,513,517 - 19,514,564NCBI
Celera14309,182 - 310,228 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14569,630 - 570,676 (+)NCBIHuRef
CHM1_11420,444,940 - 20,445,986 (+)NCBICHM1_1
T2T-CHM13v2.01414,175,053 - 14,176,027 (+)NCBIT2T-CHM13v2.0
Or4k15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391450,364,010 - 50,365,044 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1450,360,643 - 50,366,203 (+)EnsemblGRCm39 Ensembl
GRCm381450,126,553 - 50,127,587 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,123,186 - 50,128,746 (+)EnsemblGRCm38mm10GRCm38
MGSCv371450,746,228 - 50,747,262 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,048,530 - 49,049,504 (+)NCBIMGSCv36mm8
Celera1446,357,888 - 46,358,922 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1425.97NCBI
LOC100982052
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21521,484,593 - 21,485,639 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11420,701,083 - 20,702,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v014850,152 - 851,355 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11418,914,914 - 18,916,121 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1418,914,983 - 18,916,029 (+)Ensemblpanpan1.1panPan2
OR4K15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.130131,454 - 132,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30131,500 - 132,474 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3034,420 - 35,440 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.030221,199 - 222,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl30221,245 - 222,219 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.130176,495 - 177,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.030268,752 - 269,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.030316,256 - 317,277 (+)NCBIUU_Cfam_GSD_1.0
LOC100152570
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27133,402,998 - 133,404,035 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Or4k15
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000016674
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016674   ⟹   ENSRNOP00000016674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1526,887,767 - 26,888,741 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118231   ⟹   ENSRNOP00000095430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,270,833 - 23,278,421 (+)Ensembl
RefSeq Acc Id: NM_001000091   ⟹   NP_001000091
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81525,752,883 - 25,753,857 (+)NCBI
mRatBN7.21523,273,303 - 23,274,277 (+)NCBI
Rnor_6.01526,887,767 - 26,888,741 (+)NCBI
Rnor_5.01530,813,946 - 30,814,920 (+)NCBI
RGSC_v3.41526,504,566 - 26,505,540 (+)RGD
Celera1523,624,939 - 23,625,913 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000091 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88397 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095430
  ENSRNOP00000095430.1
Reference Protein Sequences
RefSeq Acc Id: NP_001000091   ⟸   NM_001000091
- UniProtKB: A0A8I6AQJ4 (UniProtKB/TrEMBL),   A6KE92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016674   ⟸   ENSRNOT00000016674
RefSeq Acc Id: ENSRNOP00000095430   ⟸   ENSRNOT00000118231
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSE2-F1-model_v2 AlphaFold D3ZSE2 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1334431 AgrOrtholog
BioCyc Gene G2FUF-14093 BioCyc
Ensembl Genes ENSRNOG00000012510 Ensembl
  ENSRNOG00000064001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000118231 ENTREZGENE
  ENSRNOT00000118231.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:290003 UniProtKB/TrEMBL
NCBI Gene 290003 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 4K15 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4k15 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012510 RatGTEx
  ENSRNOG00000064001 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6AQJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6KE92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4k15  olfactory receptor family 4 subfamily K member 15  Olr1627  olfactory receptor 1627  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1627  olfactory receptor 1627   Olr1627_predicted  olfactory receptor 1627 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1627_predicted  olfactory receptor 1627 (predicted)      Symbol and Name status set to approved 70820 APPROVED