Or4m1 (olfactory receptor family 4 subfamily M member 1) - Rat Genome Database

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Gene: Or4m1 (olfactory receptor family 4 subfamily M member 1) Rattus norvegicus
Analyze
Symbol: Or4m1
Name: olfactory receptor family 4 subfamily M member 1
RGD ID: 1333393
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in several processes, including positive regulation of appetite; positive regulation of cAMP-mediated signaling; and positive regulation of flagellated sperm motility. Predicted to be active in plasma membrane. Orthologous to several human genes including OR4M1 (olfactory receptor family 4 subfamily M member 1); INTERACTS WITH bisphenol A; furan; vinclozolin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1612; olfactory receptor gene Olr1612; olfactory receptor Olr1612; Olr1612
RGD Orthologs
Human
Mouse
Chinchilla
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,980,799 - 25,981,740 (-)NCBIGRCr8
mRatBN7.21523,507,213 - 23,508,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,507,213 - 23,508,154 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,278,486 - 26,279,427 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,239,804 - 27,240,745 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,487,028 - 25,487,969 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,139,716 - 27,140,657 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,139,716 - 27,140,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,066,249 - 31,067,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,032,642 - 26,033,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,048,341 - 26,049,283 (-)NCBI
Celera1523,839,131 - 23,840,072 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or4m1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,980,799 - 25,981,740 (-)NCBIGRCr8
mRatBN7.21523,507,213 - 23,508,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,507,213 - 23,508,154 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,278,486 - 26,279,427 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,239,804 - 27,240,745 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,487,028 - 25,487,969 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,139,716 - 27,140,657 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,139,716 - 27,140,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,066,249 - 31,067,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,032,642 - 26,033,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,048,341 - 26,049,283 (-)NCBI
Celera1523,839,131 - 23,840,072 (-)NCBICelera
Cytogenetic Map15p14NCBI
OR4M1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381419,773,504 - 19,783,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1419,773,504 - 19,783,696 (+)EnsemblGRCh38hg38GRCh38
GRCh371420,241,663 - 20,251,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,318,322 - 19,319,263 (+)NCBINCBI36Build 36hg18NCBI36
Build 341419,318,321 - 19,319,263NCBI
Celera14113,936 - 114,877 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14374,754 - 375,695 (+)NCBIHuRef
CHM1_11420,249,938 - 20,250,879 (+)NCBICHM1_1
T2T-CHM13v2.01413,972,933 - 13,983,132 (+)NCBIT2T-CHM13v2.0
Or4m1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391450,557,293 - 50,558,325 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1450,553,963 - 50,564,218 (-)EnsemblGRCm39 Ensembl
GRCm381450,319,836 - 50,320,868 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,316,506 - 50,326,761 (-)EnsemblGRCm38mm10GRCm38
MGSCv371450,939,567 - 50,940,508 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,241,843 - 49,242,784 (-)NCBIMGSCv36mm8
Celera1446,553,556 - 46,554,497 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.05NCBI
LOC102015988
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955550587,951 - 588,914 (-)NCBIChiLan1.0ChiLan1.0
LOC101958842
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,113,377 - 77,115,397 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493687795,426 - 96,548 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100153496
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2784,148,577 - 84,158,463 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC101715193
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248255,519,839 - 5,520,768 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Or4m1
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:94
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000016727
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system reproductive system respiratory system appendage
High
Medium
Low
Below cutoff 7 1 14 1 1 1 4 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016727   ⟹   ENSRNOP00000016727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,507,213 - 23,508,154 (-)Ensembl
Rnor_6.0 Ensembl1527,139,716 - 27,140,657 (-)Ensembl
RefSeq Acc Id: NM_001000096   ⟹   NP_001000096
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81525,980,799 - 25,981,740 (-)NCBI
mRatBN7.21523,507,213 - 23,508,154 (-)NCBI
Rnor_6.01527,139,716 - 27,140,657 (-)NCBI
Rnor_5.01531,066,249 - 31,067,190 (-)NCBI
RGSC_v3.41526,032,642 - 26,033,583 (-)RGD
Celera1523,839,131 - 23,840,072 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000096 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88403 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016727
  ENSRNOP00000016727.1
Reference Protein Sequences
RefSeq Acc Id: NP_001000096   ⟸   NM_001000096
- UniProtKB: D4A089 (UniProtKB/TrEMBL),   A6KE98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016727   ⟸   ENSRNOT00000016727
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A089-F1-model_v2 AlphaFold D4A089 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333393 AgrOrtholog
BioCyc Gene G2FUF-14085 BioCyc
Ensembl Genes ENSRNOG00000012545 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016727 ENTREZGENE
  ENSRNOT00000016727.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:290010 UniProtKB/TrEMBL
NCBI Gene 290010 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 4M1-RELATED UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4m1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012545 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6KE98 ENTREZGENE, UniProtKB/TrEMBL
  D4A089 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4m1  olfactory receptor family 4 subfamily M member 1  Olr1612  olfactory receptor 1612  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1612  olfactory receptor 1612   Olr1612_predicted  olfactory receptor 1612 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1612_predicted  olfactory receptor 1612 (predicted)      Symbol and Name status set to approved 70820 APPROVED