Or5k3 (olfactory receptor family 5 subfamily K member 3) - Rat Genome Database

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Gene: Or5k3 (olfactory receptor family 5 subfamily K member 3) Rattus norvegicus
Analyze
Symbol: Or5k3
Name: olfactory receptor family 5 subfamily K member 3
RGD ID: 1332965
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR5K3 (olfactory receptor family 5 subfamily K member 3); INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1542; olfactory receptor gene Olr1542; olfactory receptor Olr1542; Olr1542
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,728,228 - 54,729,154 (-)NCBIGRCr8
mRatBN7.21141,259,026 - 41,259,952 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,257,865 - 41,262,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,988,165 - 49,989,091 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,659,451 - 42,660,377 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,788,102 - 41,789,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,357,349 - 43,358,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,357,349 - 43,358,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,543,818 - 46,544,744 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,059,672 - 42,060,598 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11142,117,260 - 42,118,187 (-)NCBI
Celera1141,073,287 - 41,074,213 (-)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or5k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,728,228 - 54,729,154 (-)NCBIGRCr8
mRatBN7.21141,259,026 - 41,259,952 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,257,865 - 41,262,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,988,165 - 49,989,091 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,659,451 - 42,660,377 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,788,102 - 41,789,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,357,349 - 43,358,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,357,349 - 43,358,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,543,818 - 46,544,744 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,059,672 - 42,060,598 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11142,117,260 - 42,118,187 (-)NCBI
Celera1141,073,287 - 41,074,213 (-)NCBICelera
Cytogenetic Map11q12NCBI
OR5K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38398,390,666 - 98,391,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl398,390,666 - 98,391,631 (+)EnsemblGRCh38hg38GRCh38
GRCh37398,109,510 - 98,110,475 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,592,200 - 99,593,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 34399,592,199 - 99,593,165NCBI
Celera396,501,349 - 96,502,314 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef395,481,593 - 95,482,558 (+)NCBIHuRef
CHM1_1398,072,555 - 98,073,520 (+)NCBICHM1_1
T2T-CHM13v2.03101,094,360 - 101,095,325 (+)NCBIT2T-CHM13v2.0
Or5k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391658,969,215 - 58,970,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1658,967,409 - 58,971,140 (+)EnsemblGRCm39 Ensembl
GRCm381659,148,852 - 59,149,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1659,147,046 - 59,150,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv371659,148,678 - 59,149,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361659,091,108 - 59,092,034 (+)NCBIMGSCv36mm8
Celera1659,491,212 - 59,492,138 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1634.83NCBI
LOC100974357
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2296,321,894 - 96,322,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1396,326,677 - 96,327,616 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0395,481,458 - 95,482,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13102,164,856 - 102,165,821 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3102,164,856 - 102,165,821 (+)Ensemblpanpan1.1panPan2
OR5K18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1335,315,701 - 5,321,136 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl335,315,695 - 5,316,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0335,455,277 - 5,456,206 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl335,455,262 - 5,456,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1335,332,502 - 5,333,427 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0335,395,654 - 5,396,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,672,934 - 5,673,863 (+)NCBIUU_Cfam_GSD_1.0
LOC100157439
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113160,861,057 - 160,861,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213171,181,028 - 171,181,957 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC119625674
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604184,127,557 - 84,128,528 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or5k3
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000060891
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

respiratory system
High
Medium
Low
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060891   ⟹   ENSRNOP00000057613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,644,176 - 41,645,105 (+)Ensembl
Rnor_6.0 Ensembl1143,357,349 - 43,358,275 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104280   ⟹   ENSRNOP00000096229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,257,865 - 41,262,045 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111054   ⟹   ENSRNOP00000089085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,257,865 - 41,262,045 (-)Ensembl
RefSeq Acc Id: NM_001000531   ⟹   NP_001000531
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81154,728,228 - 54,729,154 (-)NCBI
mRatBN7.21141,259,026 - 41,259,952 (-)NCBI
Rnor_6.01143,357,349 - 43,358,275 (-)NCBI
Rnor_5.01146,543,818 - 46,544,744 (-)NCBI
RGSC_v3.41142,059,672 - 42,060,598 (-)RGD
Celera1141,073,287 - 41,074,213 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000531 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11000 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089085.1
  ENSRNOP00000096229
  ENSRNOP00000096229.1
Reference Protein Sequences
RefSeq Acc Id: NP_001000531   ⟸   NM_001000531
- UniProtKB: A0A8I6AS28 (UniProtKB/TrEMBL),   A6IQJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057613   ⟸   ENSRNOT00000060891
RefSeq Acc Id: ENSRNOP00000096229   ⟸   ENSRNOT00000104280
RefSeq Acc Id: ENSRNOP00000089085   ⟸   ENSRNOT00000111054
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAE1-F1-model_v2 AlphaFold D4AAE1 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332965 AgrOrtholog
BioCyc Gene G2FUF-21601 BioCyc
Ensembl Genes ENSRNOG00000046780 Ensembl
  ENSRNOG00000065174 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104280 ENTREZGENE
  ENSRNOT00000104280.1 UniProtKB/TrEMBL
  ENSRNOT00000111054.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:363763 UniProtKB/TrEMBL
NCBI Gene 363763 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 5K3 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or5k3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046780 RatGTEx
  ENSRNOG00000065174 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6AS28 ENTREZGENE, UniProtKB/TrEMBL
  A6IQJ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or5k3  olfactory receptor family 5 subfamily K member 3  Olr1542  olfactory receptor 1542  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1542  olfactory receptor 1542   Olr1542_predicted  olfactory receptor 1542 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1542_predicted  olfactory receptor 1542 (predicted)      Symbol and Name status set to approved 70820 APPROVED