Or6c74 (olfactory receptor family 6 subfamily C member 74) - Rat Genome Database

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Gene: Or6c74 (olfactory receptor family 6 subfamily C member 74) Rattus norvegicus
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Symbol: Or6c74
Name: olfactory receptor family 6 subfamily C member 74
RGD ID: 1332775
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR6C74 (olfactory receptor family 6 subfamily C member 74); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: LOC100910928; olfactory receptor 1064; olfactory receptor 6C74; olfactory receptor 6C74-like; olfactory receptor gene Olr1064; olfactory receptor Olr1064; Olr1064
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr877,314,102 - 7,315,040 (+)NCBIGRCr8
mRatBN7.276,663,296 - 6,664,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl76,659,998 - 6,664,564 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx79,561,716 - 9,562,654 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0711,437,374 - 11,438,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.079,245,569 - 9,246,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.079,279,620 - 9,280,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.079,454,709 - 9,455,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.478,104,864 - 8,105,802 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.178,104,863 - 8,105,802 (+)NCBI
Celera74,884,771 - 4,885,709 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or6c74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr877,314,102 - 7,315,040 (+)NCBIGRCr8
mRatBN7.276,663,296 - 6,664,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl76,659,998 - 6,664,564 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx79,561,716 - 9,562,654 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0711,437,374 - 11,438,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.079,245,569 - 9,246,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.079,279,620 - 9,280,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.079,454,709 - 9,455,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.478,104,864 - 8,105,802 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.178,104,863 - 8,105,802 (+)NCBI
Celera74,884,771 - 4,885,709 (+)NCBICelera
Cytogenetic Map7q11NCBI
OR6C74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,244,609 - 55,256,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,244,609 - 55,256,625 (+)EnsemblGRCh38hg38GRCh38
GRCh371255,638,393 - 55,650,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,927,339 - 53,928,277 (+)NCBINCBI36Build 36hg18NCBI36
Build 341253,927,338 - 53,928,277NCBI
Celera1255,293,056 - 55,293,994 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1252,679,583 - 52,680,521 (+)NCBIHuRef
CHM1_11255,607,911 - 55,608,849 (+)NCBICHM1_1
T2T-CHM13v2.01255,211,169 - 55,223,187 (+)NCBIT2T-CHM13v2.0
Or6c74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910129,869,497 - 129,870,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10129,866,217 - 129,870,940 (+)EnsemblGRCm39 Ensembl
GRCm3810130,033,628 - 130,034,560 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10130,030,348 - 130,035,071 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710129,470,684 - 129,471,616 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610129,436,577 - 129,437,509 (+)NCBIMGSCv36mm8
Celera10132,411,934 - 132,412,866 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.67NCBI
LOC100992114
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,918,304 - 38,930,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,915,073 - 38,927,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01233,499,659 - 33,500,751 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11234,227,806 - 34,228,898 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1234,227,876 - 34,228,814 (-)Ensemblpanpan1.1panPan2
OR6C74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12798,702 - 99,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2798,702 - 99,640 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2746,180,748 - 46,181,686 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.027103,681 - 104,619 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl27103,681 - 104,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12797,904 - 98,840 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02799,347 - 100,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02746,561,955 - 46,562,893 (+)NCBIUU_Cfam_GSD_1.0
LOC100623839
(Sus scrofa - pig)		 No map positions available.

Variants

.
Variants in Or6c74
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:75
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000011225, ENSRNOT00000071756
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011225   ⟹   ENSRNOP00000064979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl76,659,998 - 6,664,564 (+)Ensembl
Rnor_6.0 Ensembl79,279,620 - 9,280,558 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071756   ⟹   ENSRNOP00000065041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl139,464,906 - 9,465,844 (+)Ensembl
RefSeq Acc Id: NM_001001076   ⟹   NP_001001076
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr877,314,102 - 7,315,040 (+)NCBI
mRatBN7.276,663,296 - 6,664,234 (+)NCBI
Rnor_6.079,279,620 - 9,280,558 (+)NCBI
Rnor_5.079,454,709 - 9,455,647 (+)NCBI
RGSC_v3.478,104,864 - 8,105,802 (+)RGD
Celera74,884,771 - 4,885,709 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001001076 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89107 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064979
  ENSRNOP00000064979.1
Reference Protein Sequences
RefSeq Acc Id: NP_001001076   ⟸   NM_001001076
- UniProtKB: M0R6I9 (UniProtKB/TrEMBL),   A6K837 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064979   ⟸   ENSRNOT00000011225
RefSeq Acc Id: ENSRNOP00000065041   ⟸   ENSRNOT00000071756
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6I9-F1-model_v2 AlphaFold M0R6I9 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332775 AgrOrtholog
BioCyc Gene G2FUF-35091 BioCyc
Ensembl Genes ENSRNOG00000008499 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048744 Ensembl
Ensembl Transcript ENSRNOT00000011225 ENTREZGENE
  ENSRNOT00000011225.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
KEGG Report rno:405966 UniProtKB/TrEMBL
NCBI Gene 405966 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 6C74 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c74 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008499 RatGTEx
  ENSRNOG00000048744 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6K837 ENTREZGENE, UniProtKB/TrEMBL
  M0R6I9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6c74  olfactory receptor family 6 subfamily C member 74  Olr1064  olfactory receptor 1064  Symbol and Name Changed 1299863 APPROVED
2021-03-09 Olr1064  olfactory receptor 1064  LOC100910928  olfactory receptor 6C74-like  Data merged from RGD:6495916 737654 PROVISIONAL
2012-07-05 LOC100910928  olfactory receptor 6C74-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Olr1064  olfactory receptor 1064   Olr1064_predicted  olfactory receptor 1064 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1064_predicted  olfactory receptor 1064 (predicted)      Symbol and Name status set to approved 70820 APPROVED