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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | multiple interactions | EXP | | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; more ... | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | EXP | | 6480464 | Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA]; more ... | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | EXP | | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA | CTD | PMID:20230807 | 17beta-estradiol | multiple interactions | ISO | RGD:631332 | 6480464 | [Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA | CTD | PMID:21382399 | 17beta-estradiol | increases expression | ISO | RGD:631332 | 6480464 | Estradiol results in increased expression of TPH2 mRNA | CTD | PMID:21382399 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:736716 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TPH2 mRNA | CTD | PMID:22079614 | ammonium chloride | affects expression | ISO | RGD:631332 | 6480464 | Ammonium Chloride affects the expression of TPH2 mRNA | CTD | PMID:16483693 | caffeine | multiple interactions | EXP | | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; more ... | CTD | PMID:20230807 | fluoxetine | increases expression | ISO | RGD:631332 | 6480464 | Fluoxetine results in increased expression of TPH2 mRNA | CTD | PMID:11901216 | fluoxetine | decreases expression | ISO | RGD:631332 | 6480464 | Fluoxetine results in decreased expression of TPH2 mRNA | CTD | PMID:16982082 PMID:21740920 | fluoxetine | increases response to substance | ISO | RGD:631332 | 6480464 | TPH2 results in increased susceptibility to Fluoxetine | CTD | PMID:17950541 | fluoxetine | affects expression | EXP | | 6480464 | Fluoxetine affects the expression of TPH2 mRNA | CTD | PMID:17321503 | fluoxetine | affects expression | ISO | RGD:631332 | 6480464 | Fluoxetine affects the expression of TPH2 mRNA | CTD | PMID:17950541 | fluoxetine | decreases expression | ISO | RGD:631332 | 6480464 | Fluoxetine results in decreased expression of TPH2 mRNA | CTD | PMID:21740920 PMID:16982082 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of TPH2 mRNA | CTD | PMID:20374287 | fluoxetine | affects response to substance | ISO | RGD:736716 | 6480464 | TPH2 protein affects the susceptibility to Fluoxetine | CTD | PMID:16982082 | fluoxetine | decreases expression | ISO | RGD:631332 | 6480464 | Fluoxetine results in decreased expression of TPH2 mRNA | CTD | PMID:21740920 | fluoxetine | multiple interactions | ISO | RGD:631332 | 6480464 | [Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA | CTD | PMID:21382399 | lithium chloride | decreases expression | ISO | RGD:631332 | 6480464 | Lithium Chloride results in decreased expression of TPH2 protein; more ... | CTD | PMID:19840776 | methamphetamine | affects response to substance | EXP | | 6480464 | TPH2 protein affects the susceptibility to Methamphetamine | CTD | PMID:20722968 | serotonin | affects abundance | EXP | | 6480464 | TPH2 protein affects the abundance of Serotonin | CTD | PMID:20722968 | sertraline | multiple interactions | ISO | RGD:631332 | 6480464 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA] | CTD | PMID:11901216 | sertraline | increases expression | ISO | RGD:631332 | 6480464 | Sertraline results in increased expression of TPH2 protein; more ... | CTD | PMID:11901216 | sertraline | increases activity | ISO | RGD:631332 | 6480464 | Sertraline results in increased activity of TPH2 protein | CTD | PMID:11901216 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Serotonergic synapse | |
| Tryptophan metabolism | |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Serotonergic synapse | |
| Tryptophan metabolism | |
Phenotype Annotations
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References - curated| 1. |
Coon H, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):42-6. |
| 2. |
De Luca V, etal., Psychopharmacology (Berl). 2005 Dec;183(3):378-82. Epub 2005 Oct 21. |
| 3. |
Izikki M, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3. |
| 4. |
Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 5. |
Maron E, etal., Neurosci Lett. 2007 Jan 16;411(3):180-4. Epub 2006 Nov 22. |
| 6. |
MGD and Homologene mouse data transfer |
| 7. |
MGD data from the GO Consortium |
| 8. |
MGD IEA |
| 9. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 10. |
Ramoz N, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):861-7. |
| 11. |
RGD automated import pipeline |
| 12. |
RGD automated import pipeline for gene-chemical interactions |
| 13. |
RGD Automated Pipelines |
| 14. |
Walther DJ, etal., Science 2003 Jan 3;299(5603):76. |
References - uncurated| PubMed | 10922068 |
| 12477932 | |
| 12584449 | |
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| 14597720 | |
| 14602809 | |
| 14681479 | |
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| 18923670 | |
| 19006079 | |
| 19181488 | |
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| 19906978 | |
| 20080794 | |
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| 21677183 | |
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| 22450231 | |
| 22534482 | |
| 22561036 | |
| 22912815 | |
| 22937132 | |
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| 23007167 |
RGD Disease Portals| Tph2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tph2 (Mus musculus) |
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| TPH2 (Homo sapiens) |
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| Tph2 (Rattus norvegicus) |
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Position Markers| AU043594 |
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| Tph2 |
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| PMC263847P2 |
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| Tph2 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_173391 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01089058 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01089059 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01089060 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01089061 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01089062 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01089063 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01089064 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC153825 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY090565 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC120514 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC125430 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466539 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_173391 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_775567 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_775567 | (Get FASTA) |
| GenBank Protein | AAI20515 | (Get FASTA) |
| AAI25431 | (Get FASTA) | |
| AAM08923 | (Get FASTA) | |
| EDL21762 | (Get FASTA) | |
| Q8CGV2 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000006764 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000006949 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000006949 | ENTREZGENE |
| Entrez Gene | 216343 | ENTREZGENE |
| Gene3D-CATH | Aaa_hydroxylase | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000006764 | |
| HomoloGene Group ID | 27831 | ENTREZGENE |
| InterPro | ACT-bd | UniProtKB/Swiss-Prot |
| ArAA_hydroxylase | UniProtKB/Swiss-Prot | |
| ArAA_hydroxylase_Fe/CU_BS | UniProtKB/Swiss-Prot | |
| Aromatic-AA_hydroxylase_C | UniProtKB/Swiss-Prot | |
| Trp_5_mOase | UniProtKB/Swiss-Prot | |
| Tyrosine_3-monooxygenase-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00229583 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:216343 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:2651811 | ENTREZGENE |
| PANTHER | Aaa_hydroxylase | UniProtKB/Swiss-Prot |
| Pfam | ACT | UniProtKB/Swiss-Prot |
| Biopterin_H | UniProtKB/Swiss-Prot | |
| PharmGKB | TPH2 | RGD |
| PIRSF | PIRSF000336 | UniProtKB/Swiss-Prot |
| PRINTS | FYWHYDRXLASE | UniProtKB/Swiss-Prot |
| PROSITE | BH4_AAA_HYDROXYL_1 | UniProtKB/Swiss-Prot |
| BH4_AAA_HYDROXYL_2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Aaa_hydroxylase | UniProtKB/Swiss-Prot |
| TIGRFAMs | Trp_5_monoox | UniProtKB/Swiss-Prot |
| UniGene | Mm.31597 | ENTREZGENE |
| UniProt | TPH2_MOUSE | UniProtKB/Swiss-Prot |
| More on Tph2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1332580 |
| Created: | 2005-02-01 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.