Adap1 (ArfGAP with dual PH domains 1) - Rat Genome Database

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Gene: Adap1 (ArfGAP with dual PH domains 1) Mus musculus
Analyze
Symbol: Adap1
Name: ArfGAP with dual PH domains 1
RGD ID: 1332398
MGI Page MGI
Description: Predicted to enable GTPase activator activity; inositol 1,3,4,5 tetrakisphosphate binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in nervous system. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930431P11Rik; arf-GAP with dual PH domain-containing protein 1; Cent; Centa1; centaurin, alpha 1; GC1L; p42IP4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,257,631 - 139,311,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,257,631 - 139,311,377 (-)EnsemblGRCm39 Ensembl
GRCm385139,271,876 - 139,325,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,271,876 - 139,325,622 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,747,830 - 139,801,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,525,518 - 139,559,961 (-)NCBIMGSCv36mm8
Celera5136,325,945 - 136,379,615 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18799693   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:26764384   PMID:30333137   PMID:30973865   PMID:31792062   PMID:33139322   PMID:34815492  


Genomics

Comparative Map Data
Adap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,257,631 - 139,311,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,257,631 - 139,311,377 (-)EnsemblGRCm39 Ensembl
GRCm385139,271,876 - 139,325,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,271,876 - 139,325,622 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,747,830 - 139,801,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,525,518 - 139,559,961 (-)NCBIMGSCv36mm8
Celera5136,325,945 - 136,379,615 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.27NCBI
ADAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387897,900 - 955,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7897,900 - 955,407 (-)EnsemblGRCh38hg38GRCh38
GRCh377937,537 - 995,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367904,066 - 960,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 347710,780 - 767,508NCBI
Celera7906,136 - 962,035 (-)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7855,527 - 893,573 (-)NCBIHuRef
CHM1_17936,645 - 993,431 (-)NCBICHM1_1
T2T-CHM13v2.071,001,683 - 1,060,405 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27992,062 - 1,048,924 (-)NCBI
Adap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,438,091 - 20,489,961 (+)NCBIGRCr8
mRatBN7.21215,323,913 - 15,376,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,324,209 - 15,380,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,134,353 - 16,186,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,758,093 - 16,809,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,784,243 - 15,836,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,416,327 - 17,468,212 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,416,327 - 17,468,212 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,402,559 - 19,454,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,825,017 - 15,877,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,855,021 - 15,906,562 (+)NCBI
Celera1217,078,350 - 17,130,259 (+)NCBICelera
Cytogenetic Map12q11NCBI
Adap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,635,463 - 8,674,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,635,463 - 8,674,455 (-)NCBIChiLan1.0ChiLan1.0
ADAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,841,176 - 5,899,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,165,865 - 54,224,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,054,499 - 1,112,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,269,235 - 1,316,351 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,269,235 - 1,326,102 (-)Ensemblpanpan1.1panPan2
ADAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,921,865 - 15,976,101 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,898,326 - 15,973,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,394,927 - 17,448,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,052,553 - 16,105,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,028,493 - 16,105,914 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,855,375 - 15,908,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,781,938 - 15,835,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,070,134 - 16,124,464 (+)NCBIUU_Cfam_GSD_1.0
Adap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,855,837 - 143,879,769 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,131,500 - 1,154,528 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,130,585 - 1,154,459 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3547,364 - 615,471 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13548,823 - 615,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23429,376 - 430,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.23695,020 - 722,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,617,948 - 20,677,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,617,995 - 20,680,628 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,013,133 - 1,073,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,481,054 - 26,518,469 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,481,036 - 26,518,315 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adap1
1657 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1554
Count of miRNA genes:591
Interacting mature miRNAs:726
Transcripts:ENSMUST00000110865, ENSMUST00000123748, ENSMUST00000126762, ENSMUST00000151450, ENSMUST00000156815
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse

Markers in Region
UniSTS:224251  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385139,288,423 - 139,288,593UniSTSGRCm38
MGSCv375139,764,377 - 139,764,547UniSTSGRCm37
Celera5136,342,573 - 136,342,743UniSTS
Cytogenetic Map5G2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000110865   ⟹   ENSMUSP00000106489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,257,631 - 139,311,377 (-)Ensembl
GRCm38.p6 Ensembl5139,271,876 - 139,325,622 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,258,685 - 139,260,396 (-)Ensembl
GRCm38.p6 Ensembl5139,272,930 - 139,274,641 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126762
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,258,613 - 139,292,046 (-)Ensembl
GRCm38.p6 Ensembl5139,272,858 - 139,306,291 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,257,631 - 139,292,074 (-)Ensembl
GRCm38.p6 Ensembl5139,271,876 - 139,306,319 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156815
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,266,277 - 139,293,564 (-)Ensembl
GRCm38.p6 Ensembl5139,280,522 - 139,307,809 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,258,531 - 139,288,905 (-)Ensembl
GRCm38.p6 Ensembl5139,272,776 - 139,303,150 (-)Ensembl
RefSeq Acc Id: NM_172723   ⟹   NP_766311
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,257,631 - 139,311,219 (-)NCBI
GRCm385139,271,876 - 139,325,464 (-)ENTREZGENE
MGSCv375139,747,830 - 139,801,418 (-)RGD
Celera5136,325,945 - 136,379,615 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504669   ⟹   XP_006504732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,257,631 - 139,311,516 (-)NCBI
GRCm385139,271,882 - 139,325,763 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_766311   ⟸   NM_172723
- UniProtKB: E9PY16 (UniProtKB/TrEMBL),   Q6PGM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006504732   ⟸   XM_006504669
- Peptide Label: isoform X1
- UniProtKB: Q8BVR8 (UniProtKB/TrEMBL),   Q6PGM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106489   ⟸   ENSMUST00000110865
Protein Domains
Arf-GAP   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PY16-F1-model_v2 AlphaFold E9PY16 1-374 view protein structure

Promoters
RGD ID:6888546
Promoter ID:EPDNEW_M7724
Type:initiation region
Name:Adap1_1
Description:Mus musculus ArfGAP with dual PH domains 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385139,325,533 - 139,325,593EPDNEW
RGD ID:6848810
Promoter ID:MM_TRO:7886
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:MTR008091.5.2734.4
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365139,749,149 - 139,749,649 (-)MPROMDB
RGD ID:6836993
Promoter ID:MM_KWN:44603
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000062040
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365139,750,596 - 139,751,097 (-)MPROMDB
RGD ID:6836994
Promoter ID:MM_KWN:44606
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000062039
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365139,783,446 - 139,783,946 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442201 AgrOrtholog
Ensembl Genes ENSMUSG00000056413 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000110865 ENTREZGENE
  ENSMUST00000110865.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ArfGAP UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/TrEMBL
  PH1_ADAP UniProtKB/TrEMBL
  PH2_ADAP UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report mmu:231821 UniProtKB/TrEMBL
MGD MGI:2442201 ENTREZGENE
NCBI Gene 231821 ENTREZGENE
PANTHER ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam ArfGap UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Adap1 PhenoGen
PRINTS REVINTRACTNG UniProtKB/TrEMBL
PROSITE ARFGAP UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART ArfGap UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF57863 UniProtKB/TrEMBL
UniProt B7ZMY4_MOUSE UniProtKB/TrEMBL
  E9PY16 ENTREZGENE, UniProtKB/TrEMBL
  Q6PGM4 ENTREZGENE, UniProtKB/TrEMBL
  Q8BVR8 ENTREZGENE, UniProtKB/TrEMBL
  Q8BVS1_MOUSE UniProtKB/TrEMBL