Gene: Setd8 (SET domain containing (lysine methyltransferase) 8) Mus musculus
Symbol: Setd8
Name: SET domain containing (lysine methyltransferase) 8
Description: ENCODES a protein that exhibits histone-lysine N-methyltransferase activity (ortholog); p53 binding (ortholog); protein-lysine N-methyltransferase activity (ortholog); INVOLVED IN histone lysine methylation (ortholog); negative regulation of transcription from RNA polymerase II promoter (ortholog); negative regulation of transcription, DNA-templated (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH abnormal cell cycle checkpoint function; abnormal cell physiology; abnormal DNA repair; ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410195B05Rik; AA617402; AW536475; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; Kmt5a; lysine-specific methylase 5A; MGC117832; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; OTTMUSP00000018671; OTTMUSP00000018672; PR-SET7; PR/SET domain-containing protein 07; PR/SET07; SET domain-containing protein 8
Related Pseudogenes: Gm11424   Gm8590   Gm8770  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm385124,439,930 - 124,462,308 (+)NCBIGRCm38mm10GRCm38
MGSCv375124,889,939 - 124,912,316 (+)NCBIGRCm37mm9NCBIm37
MGSCv365124,700,548 - 124,722,925 (+)NCBImm8
Celera5121,513,480 - 121,535,737 (+)NCBI
Cytogenetic Map5 FNCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Setd8
Entrez Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1332274
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2016-05-10
Status: ACTIVE