PIDD (p53-induced death domain protein)

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Keyword

Gene: PIDD (p53-induced death domain protein) Homo sapiens

Symbol:

PIDD

Name:

p53-induced death domain protein

Description:

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

DKFZp434D229; leucine-rich and death domain containing; leucine-rich repeat and death domain-containing protein; leucine-rich repeats and death domain containing; LRDD; MGC16925; OTTHUMP00000164429; OTTHUMP00000229971; p53-induced death domain protein; p53-induced protein with a death domain

Orthologs:

Mus musculus : Lrdd (leucine-rich and death domain containing) MGI
Rattus norvegicus : Pidd (p53-induced death domain protein)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	11	735,782 - 741,853	-	NCBI
Human Genome Assembly HuRef	11	615,945 - 621,235	-	NCBI
Human Genome Assembly GRCh37	11	799,179 - 805,250	-	NCBI
Human Genome Assembly Build 36	11	789,179 - 795,245	-	NCBI
Human Cytogenetic Map	11	p15.5		NCBI
Human Genome Assembly	11	789,178 - 794,464		NCBI