Vasp (vasodilator-stimulated phosphoprotein)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Home
Data
Genome Tools
Diseases
Phenotypes & Models
KnockOuts
Pathways
Community
Curation Web

Search RGD
Grant Resources
Citing RGD
About Us
Contact Us

Genes
QTLs
Strains
Markers
Maps
Ontologies
Sequences
References
FTP Download
Submit Data

Rat GBrowse
VCMap
Variant Visualizer
GViewer
ACP Haplotyper
Genome Scanner
Genome Conflicts
RatMine

Diabetes
Cardiovascular
Neurological
Obesity/Metabolic Syndrome
Cancer
Respiratory

Phenotypes
Strains & Models
PhenoMiner Database

Molecular Pathways
Physiological Pathways

Nomenclature
Rat Community Forum (RCF)
Submit Data

Object Edit
Curation Tools
Nomenclature
Score Board
Pipeline Logs
Phenominer

General
Array IDs

Gene: Vasp (vasodilator-stimulated phosphoprotein) Mus musculus

Symbol:

Vasp

Name:

vasodilator-stimulated phosphoprotein

Description:

ENCODES a protein that exhibits profilin binding (ortholog); INVOLVED IN actin cytoskeleton organization; axon guidance; neural tube closure; PARTICIPATES IN E-cadherin signaling pathway; ASSOCIATED WITH abnormal brain pia mater morphology; abnormal brain ventricle morphology; abnormal brain white matter morphology; FOUND IN filopodium; focal adhesion; lamellipodium; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetaldehyde

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

AA107290; OTTMUSP00000029531; vasodilator-stimulated phosphoprotein

Orthologs:

Homo sapiens : VASP (vasodilator-stimulated phosphoprotein) HGNC
Rattus norvegicus : Vasp (vasodilator-stimulated phosphoprotein)

Latest Assembly:

Mouse Genome Assembly Build 37

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	7	19,256,929 - 19,271,854	-	NCBI
Mouse cM Map	7		-	NCBI
Mouse Celera Assembly	7	16,669,928 - 16,684,971	-	NCBI
Mouse Genome Assembly Build 37	7	19,842,278 - 19,857,203	-	NCBI
Mouse Genome Assembly Build 36.1	7	19,843,066 - 19,858,496	-	NCBI
Mouse Cytogenetic Map	7	A3		NCBI

Model

Launch Genome Browser (GBrowse)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
17alpha-ethynylestradiol	multiple interactions	EXP		6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VASP mRNA	CTD	PMID:17942748
17beta-estradiol	decreases phosphorylation	ISO	RGD:1311542	6480464	Estradiol deficiency results in decreased phosphorylation of VASP protein	CTD	PMID:18787021
17beta-hydroxy-5alpha-androstan-3-one	multiple interactions	ISO	RGD:1323055	6480464	[Dihydrotestosterone results in increased activity of AR protein mutant form] which results in increased phosphorylation of VASP protein	CTD	PMID:18819937
2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]	multiple interactions	ISO	RGD:1311542	6480464	nebivolol inhibits the reaction [Phorbol Esters results in decreased phosphorylation of VASP protein]; more ...	CTD	PMID:16940222
2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VASP mRNA	CTD	PMID:17942748
2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of VASP mRNA	CTD	PMID:21570461
acetaldehyde	affects expression	EXP		6480464	Acetaldehyde affects the expression of VASP mRNA	CTD	PMID:22634333
all-trans-retinoic acid	increases expression	ISO	RGD:1323055	6480464	Tretinoin results in increased expression of VASP mRNA	CTD	PMID:15498508
benomyl	multiple interactions	ISO	RGD:1311542	6480464	Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein]; more ...	CTD	PMID:15331769
benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of VASP mRNA	CTD	PMID:19770486
cadmium atom	increases expression	ISO	RGD:1323055	6480464	Cadmium results in increased expression of VASP mRNA	CTD	PMID:22562489
carbamazepine	affects expression	EXP		6480464	Carbamazepine affects the expression of VASP mRNA	CTD	PMID:22634333
choline	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VASP gene	CTD	PMID:20938992
chromium atom	multiple interactions	ISO	RGD:1311542	6480464	Chromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein]	CTD	PMID:17215582
cobalt dichloride	decreases expression	ISO	RGD:1323055	6480464	cobaltous chloride results in decreased expression of VASP mRNA	CTD	PMID:19320972
copper(2+) sulfate	increases expression	ISO	RGD:1323055	6480464	Copper Sulfate results in increased expression of VASP mRNA	CTD	PMID:19549813
curcumin	increases expression	ISO	RGD:1323055	6480464	Curcumin results in increased expression of VASP mRNA	CTD	PMID:17198877
cycloheximide	multiple interactions	EXP		6480464	VASP mutant form promotes the reaction [[TNF co-treated with Cycloheximide] results in increased cleavage of SPNA2 protein]; more ...	CTD	PMID:18182247
DDE	multiple interactions	ISO	RGD:1323055	6480464	[Dichlorodiphenyl Dichloroethylene results in increased activity of AR protein mutant form] which results in increased phosphorylation of VASP protein	CTD	PMID:18819937
dexamethasone	decreases expression	ISO	RGD:1311542	6480464	Dexamethasone results in decreased expression of VASP mRNA	CTD	PMID:20032058
dexamethasone	multiple interactions	ISO	RGD:1311542	6480464	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of VASP mRNA]	CTD	PMID:20032058
dibutyl phthalate	increases expression	EXP		6480464	Dibutyl Phthalate results in increased expression of VASP mRNA	CTD	PMID:21266533
dibutyl phthalate	increases expression	EXP		6480464	Dibutyl Phthalate results in increased expression of VASP mRNA	CTD	PMID:17361019 PMID:21266533
dibutyl phthalate	increases expression	ISO	RGD:1311542	6480464	Dibutyl Phthalate results in increased expression of VASP mRNA	CTD	PMID:21266533
dioxygen	affects localization	EXP		6480464	Oxygen deficiency affects the localization of VASP protein	CTD	PMID:20164382
folic acid	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VASP gene	CTD	PMID:20938992
hemin	multiple interactions	ISO	RGD:1311542	6480464	Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]	CTD	PMID:17541025
L-methionine	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VASP gene	CTD	PMID:20938992
lead diacetate	decreases expression	EXP		6480464	lead acetate results in decreased expression of VASP mRNA	CTD	PMID:21829687
methylmercury chloride	affects expression	EXP		6480464	methylmercuric chloride affects the expression of VASP mRNA	CTD	PMID:21613230
nitroglycerin	multiple interactions	ISO	RGD:1323055	6480464	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]	CTD	PMID:17868048
nitroglycerin	increases phosphorylation	ISO	RGD:1323055	6480464	Nitroglycerin results in increased phosphorylation of VASP protein	CTD	PMID:17868048 PMID:20129490
nitroglycerin	decreases phosphorylation	ISO	RGD:1311542	6480464	Nitroglycerin results in decreased phosphorylation of VASP protein	CTD	PMID:17541025 PMID:11331261
nitroglycerin	increases phosphorylation	ISO	RGD:1311542	6480464	Nitroglycerin results in increased phosphorylation of VASP protein	CTD	PMID:15331769 PMID:14551241
nitroglycerin	increases phosphorylation	ISO	RGD:1311542	6480464	Nitroglycerin results in increased phosphorylation of VASP protein	CTD	PMID:14551241 PMID:15331769
nitroglycerin	decreases phosphorylation	ISO	RGD:1311542	6480464	Nitroglycerin results in decreased phosphorylation of VASP protein	CTD	PMID:11331261 PMID:17541025
nitroglycerin	multiple interactions	ISO	RGD:1311542	6480464	Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]	CTD	PMID:17541025
nitroglycerin	multiple interactions	ISO	RGD:1311542	6480464	Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]	CTD	PMID:15331769
nitroglycerin	increases phosphorylation	ISO	RGD:1323055	6480464	Nitroglycerin results in increased phosphorylation of VASP protein	CTD	PMID:17868048
paracetamol	affects expression	EXP		6480464	Acetaminophen affects the expression of VASP mRNA	CTD	PMID:17562736
paraquat	decreases expression	EXP		6480464	Paraquat results in decreased expression of VASP mRNA	CTD	PMID:12595580
pentaerythritol tetranitrate	multiple interactions	ISO	RGD:1311542	6480464	Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein]	CTD	PMID:15331769
pentaerythritol tetranitrate	increases phosphorylation	ISO	RGD:1311542	6480464	Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein	CTD	PMID:15331769 PMID:17541025
pentaerythritol tetranitrate	increases phosphorylation	ISO	RGD:1311542	6480464	Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein	CTD	PMID:17541025 PMID:15331769
prostaglandin E1	increases phosphorylation	ISO	RGD:1323055	6480464	Alprostadil results in increased phosphorylation of VASP protein	CTD	PMID:20129490
prostaglandin E2	increases phosphorylation	EXP		6480464	Dinoprostone results in increased phosphorylation of VASP protein	CTD	PMID:18182247
resveratrol	increases phosphorylation	ISO	RGD:1323055	6480464	resveratrol results in increased phosphorylation of VASP protein	CTD	PMID:17868048
resveratrol	increases phosphorylation	ISO	RGD:1323055	6480464	resveratrol results in increased phosphorylation of VASP protein	CTD	PMID:17868048 PMID:18716157
resveratrol	decreases expression	ISO	RGD:1323055	6480464	resveratrol results in decreased expression of VASP protein	CTD	PMID:18089832
resveratrol	multiple interactions	ISO	RGD:1311542	6480464	[resveratrol results in increased activity of GSK3B protein] which results in increased phosphorylation of VASP protein	CTD	PMID:19135050
resveratrol	multiple interactions	ISO	RGD:1323055	6480464	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased phosphorylation of VASP protein]	CTD	PMID:17868048
simvastatin	decreases phosphorylation	EXP		6480464	Simvastatin results in decreased phosphorylation of VASP protein	CTD	PMID:19332549
staurosporine	multiple interactions	EXP		6480464	VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPNA2 protein]]; more ...	CTD	PMID:18182247
sucrose	multiple interactions	ISO	RGD:1311542	6480464	Chromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein]	CTD	PMID:17215582
sucrose	decreases phosphorylation	ISO	RGD:1311542	6480464	Sucrose results in decreased phosphorylation of VASP protein	CTD	PMID:17215582
tamibarotene	increases expression	ISO	RGD:1323055	6480464	Am 80 results in increased expression of VASP mRNA; more ...	CTD	PMID:15498508
testosterone	multiple interactions	ISO	RGD:1311542	6480464	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of VASP mRNA]	CTD	PMID:20032058
testosterone enanthate	affects expression	ISO	RGD:1323055	6480464	testosterone enanthate affects the expression of VASP mRNA	CTD	PMID:17440010
trans-resveratrol	increases phosphorylation	ISO	RGD:1323055	6480464	resveratrol results in increased phosphorylation of VASP protein	CTD	PMID:17868048
trans-resveratrol	increases phosphorylation	ISO	RGD:1323055	6480464	resveratrol results in increased phosphorylation of VASP protein	CTD	PMID:17868048 PMID:18716157
trans-resveratrol	decreases expression	ISO	RGD:1323055	6480464	resveratrol results in decreased expression of VASP protein	CTD	PMID:18089832
trans-resveratrol	multiple interactions	ISO	RGD:1311542	6480464	[resveratrol results in increased activity of GSK3B protein] which results in increased phosphorylation of VASP protein	CTD	PMID:19135050
trans-resveratrol	multiple interactions	ISO	RGD:1323055	6480464	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased phosphorylation of VASP protein]	CTD	PMID:17868048
valproic acid	affects expression	EXP		6480464	Valproic Acid affects the expression of VASP mRNA	CTD	PMID:17292431
valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of VASP mRNA	CTD	PMID:22045034
valproic acid	increases expression	EXP		6480464	Valproic Acid results in increased expression of VASP mRNA	CTD	PMID:21427059
vancomycin	decreases expression	EXP		6480464	Vancomycin results in decreased expression of VASP mRNA	CTD	PMID:18930951

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
actin cytoskeleton organization		IGI	MGI:MGI:108360	2290270	MGI:MGI:3054149\|PMID:15371503	MGI	MGI:MGI:3054149 PMID:15371503
actin polymerization or depolymerization		IEA	InterPro:IPR017354	2290270	MGI:MGI:2152098	UniProtKB	MGI:MGI:2152098
axon guidance		IGI	MGI:MGI:108360	2290270	MGI:MGI:3054149\|PMID:15371503	MGI	MGI:MGI:3054149 PMID:15371503
neural tube closure		IGI	MGI:MGI:108360	2290270	MGI:MGI:3054149\|PMID:15371503	MGI	MGI:MGI:3054149 PMID:15371503
protein homotetramerization		IEA	InterPro:IPR017354	2290270	MGI:MGI:2152098	UniProtKB	MGI:MGI:2152098

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cell junction		IEA	UniProtKB-KW:KW-0965	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194
cell projection		IEA	UniProtKB-KW:KW-0966	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194
cytoplasm		ISO	UniProtKB:P50552	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
cytoskeleton		IEA	InterPro:IPR017354	2290270	MGI:MGI:2152098	UniProtKB	MGI:MGI:2152098
cytoskeleton		IEA	UniProtKB-KW:KW-0206	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194
filopodium		IDA		2290270	MGI:MGI:3046012\|PMID:15148305	MGI	MGI:MGI:3046012 PMID:15148305
filopodium		IDA		2290270	MGI:MGI:3051184\|PMID:15294161	MGI	MGI:MGI:3051184 PMID:15294161
focal adhesion		IDA		2290270	MGI:MGI:3046012\|PMID:15148305	MGI	MGI:MGI:3046012 PMID:15148305
focal adhesion		ISO	UniProtKB:P50552	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
lamellipodium		IDA		2290270	MGI:MGI:3046012\|PMID:15148305	MGI	MGI:MGI:3046012 PMID:15148305
membrane		IEA	UniProtKB-KW:KW-0472	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194
plasma membrane		ISO	UniProtKB:P50552	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
actin binding		IEA	InterPro:IPR017354	2290270	MGI:MGI:2152098	UniProtKB	MGI:MGI:2152098
actin binding		IEA	UniProtKB-KW:KW-0009	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194
profilin binding		ISO	UniProtKB:P50552	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
protein binding		IPI	UniProtKB:F2Z408	2290270	MGI:MGI:4462113\|PMID:20417104	MGI	MGI:MGI:4462113 PMID:20417104
protein binding		IPI	UniProtKB:P70460	2290270	MGI:MGI:3056009\|PMID:15465019	MGI	MGI:MGI:3056009 PMID:15465019
SH3 domain binding		IEA	InterPro:IPR017354	2290270	MGI:MGI:2152098	UniProtKB	MGI:MGI:2152098
SH3 domain binding		IEA	UniProtKB-KW:KW-0729	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194

Molecular Pathway Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E-cadherin signaling pathway		ISO	RGD:1323055	6484113		PID	PID:200182
E-cadherin signaling pathway		ISO	RGD:1323055	6484113		PID	PID:200147

External Database Links
KEGG Pathway	Fc gamma R-mediated phagocytosis
	Focal adhesion
	Leukocyte transendothelial migration
Pathway Interaction Database	E-cadherin signaling in keratinocytes (PID:200147)
	IL8- and CXCR2-mediated signaling events (PID:200167)
	PAR1-mediated thrombin signaling events (PID:200189)
	Stabilization and expansion of the E-cadherin adherens junction (PID:200182)

Phenotype Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
abnormal brain pia mater morphology		IAGP		5509061		MGI	PMID:17988629
abnormal brain ventricle morphology		IAGP		5509061		MGI	PMID:17988629
abnormal brain white matter morphology		IAGP		5509061		MGI	PMID:17988629
abnormal cell adhesion		IAGP		5509061		MGI	PMID:22908313
abnormal cortical intermediate zone morphology		IAGP		5509061		MGI	PMID:17988629
abnormal cortical plate morphology		IAGP		5509061		MGI	PMID:17988629
abnormal neurite morphology		IAGP		5509061		MGI	PMID:17988629
abnormal platelet activation		IAGP		5509061		MGI	PMID:10393958
abnormal platelet physiology		IAGP		5509061		MGI	PMID:9878048
abnormal radial glial cell morphology		IAGP		5509061		MGI	PMID:17988629
abnormal subarachnoid space morphology		IAGP		5509061		MGI	PMID:17988629
absent brain internal capsule		IAGP		5509061		MGI	PMID:17988629
complete lethality throughout fetal growth and development		IAGP		5509061		MGI	PMID:17988629
ectopic cortical neuron		IAGP		5509061		MGI	PMID:17988629
exencephaly		IAGP		5509061		MGI	PMID:17988629
hemorrhage		IAGP		5509061		MGI	PMID:17988629
hydroencephaly		IAGP		5509061		MGI	PMID:17988629
hydrops fetalis		IAGP		5509061		MGI	PMID:17988629
increased megakaryocyte cell number		IAGP		5509061		MGI	PMID:10393958
increased platelet aggregation		IAGP		5509061		MGI	PMID:9878048
partial lethality during fetal growth through weaning		IAGP		5509061		MGI	PMID:17988629

Gene-Chemical Interaction Annotations

	17alpha-ethynylestradiol (EXP)
	17beta-estradiol (ISO)
	17beta-hydroxy-5alpha-androstan-3-one (ISO)
	2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] (ISO)
	2,3,7,8-tetrachlorodibenzodioxine (EXP)
	acetaldehyde (EXP)
	all-trans-retinoic acid (ISO)
	benomyl (ISO)
	benzo[a]pyrene (EXP)
	cadmium atom (ISO)
	carbamazepine (EXP)
	choline (EXP)
	chromium atom (ISO)
	cobalt dichloride (ISO)
	copper(2+) sulfate (ISO)

	curcumin (ISO)
	cycloheximide (EXP)
	DDE (ISO)
	dexamethasone (ISO)
	dibutyl phthalate (EXP,ISO)
	dioxygen (EXP)
	folic acid (EXP)
	hemin (ISO)
	L-methionine (EXP)
	lead diacetate (EXP)
	methylmercury chloride (EXP)
	nitroglycerin (ISO)
	paracetamol (EXP)
	paraquat (EXP)
	pentaerythritol tetranitrate (ISO)

	prostaglandin E1 (ISO)
	prostaglandin E2 (EXP)
	resveratrol (ISO)
	simvastatin (EXP)
	staurosporine (EXP)
	sucrose (ISO)
	tamibarotene (ISO)
	testosterone (ISO)
	testosterone enanthate (ISO)
	trans-resveratrol (ISO)
	valproic acid (EXP)
	vancomycin (EXP)

Gene Ontology Annotations

Biological Process

	actin cytoskeleton organization (IGI)
	actin polymerization or depolymerization (IEA)
	axon guidance (IGI)

	neural tube closure (IGI)
	protein homotetramerization (IEA)

Cellular Component

	cell junction (IEA)
	cell projection (IEA)
	cytoplasm (ISO)
	cytoskeleton (IEA)

	filopodium (IDA)
	focal adhesion (IDA,ISO)
	lamellipodium (IDA)
	membrane (IEA)

plasma membrane (ISO)

Molecular Function

	actin binding (IEA)
	profilin binding (ISO)

	protein binding (IPI)
	SH3 domain binding (IEA)

Molecular Pathway Annotations

E-cadherin signaling pathway (ISO)

External Database Links
KEGG Pathway	Fc gamma R-mediated phagocytosis
	Focal adhesion
	Leukocyte transendothelial migration
Pathway Interaction Database	E-cadherin signaling in keratinocytes (PID:200147)
	IL8- and CXCR2-mediated signaling events (PID:200167)
	PAR1-mediated thrombin signaling events (PID:200189)
	Stabilization and expansion of the E-cadherin adherens junction (PID:200182)

Phenotype Annotations

	abnormal brain pia mater morphology (IAGP)
	abnormal brain ventricle morphology (IAGP)
	abnormal brain white matter morphology (IAGP)
	abnormal cell adhesion (IAGP)
	abnormal cortical intermediate zone morphology (IAGP)
	abnormal cortical plate morphology (IAGP)
	abnormal neurite morphology (IAGP)
	abnormal platelet activation (IAGP)

	abnormal platelet physiology (IAGP)
	abnormal radial glial cell morphology (IAGP)
	abnormal subarachnoid space morphology (IAGP)
	absent brain internal capsule (IAGP)
	complete lethality throughout fetal growth and development (IAGP)
	ectopic cortical neuron (IAGP)
	exencephaly (IAGP)
	hemorrhage (IAGP)

	hydroencephaly (IAGP)
	hydrops fetalis (IAGP)
	increased megakaryocyte cell number (IAGP)
	increased platelet aggregation (IAGP)
	partial lethality during fetal growth through weaning (IAGP)

References - curated

1.	Mejillano MR, etal., Cell 2004 Aug 6;118(3):363-73.
2.	MGD data from the GO Consortium
3.	MGD IEA
4.	Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
5.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	RGD automated import pipeline
7.	RGD automated import pipeline for gene-chemical interactions

References - uncurated

PubMed	10069337
	10085070
	10349636
	10393958
	10660044
	10747096
	10882740
	10922068
	11042159
	11076861
	11217851
	11810195
	12055190
	12372613
	12466851
	12477932
	12520002
	12805219
	12904583
	12933343
	12933589
	12940993
	14506234
	14610273
	15148305
	15371503
	15465019
	15489334
	15578270
	15642358
	15743999
	16141072
	16141073
	16319076
	16602821
	16940418
	17361081
	17452473
	17475772
	17920567
	17967808
	17988629
	17989211
	17998398
	18001770
	18195108
	18283104
	18799693
	19118163
	19347869
	19386231
	19435808
	19690214
	19733667
	19734360
	19798690
	19806269
	19825941
	19996090
	20044140
	20081189
	20382123
	20404115
	20417104
	20483741
	20945373
	21151938
	21267068
	21606399
	21607702
	21762694
	21795685
	21903940
	21911751
	21945940
	22216296
	22427743
	22908313
	22915108
	22932701
	8812448
	9878048

RGD Disease Portals

Vasp has been annotated in the following RGD Disease Portals.

Cancer Pathways

Cardiovascular Pathways

Cardiovascular Phenotypes

Diabetes Pathways

Immune and Inflammatory Pathways

Biological Process

Neurological Pathways

Neurological Phenotypes

Obesity Pathways

Respiratory Pathways

Genomics

Comparative Map Data

Vasp (Mus musculus)

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	7	19,256,929 - 19,271,854	-	NCBI
Mouse cM Map	7		-	NCBI
Mouse Celera Assembly	7	16,669,928 - 16,684,971	-	NCBI
Mouse Genome Assembly Build 37	7	19,842,278 - 19,857,203	-	NCBI
Mouse Genome Assembly Build 36.1	7	19,843,066 - 19,858,496	-	NCBI
Mouse Cytogenetic Map	7	A3		NCBI

VASP (Homo sapiens)

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	19	46,200,329 - 46,219,974	+	NCBI
Human Genome Assembly HuRef	19	42,440,143 - 42,459,463	+	NCBI
Human Genome Assembly GRCh37	19	46,010,688 - 46,030,241	+	NCBI
Human Genome Assembly Build 36	19	50,702,528 - 50,722,081	+	NCBI
Human Cytogenetic Map	19	q13.32		NCBI
Human Genome Assembly	19	50,702,527 - 50,722,078		NCBI

Vasp (Rattus norvegicus)

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	1	q21		NCBI
RGSC Genome Assembly v5.0	1	81,437,097 - 81,452,365	-	NCBI
RGSC Genome Assembly v3.4	1	78,621,494 - 78,636,762	-	NCBI
Rat Celera Assembly	1	73,372,332 - 73,387,227	-	NCBI
Genome Assembly 3.1	1	78,699,598 - 78,715,028	-	NCBI

Position Markers

UniSTS:235612

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	7	19,264,743 - 19,264,828	UniSTS
Mouse cM Map	7	4.0	UniSTS
Mouse Celera Assembly	7	16,677,837 - 16,677,922	UniSTS
Mouse Genome Assembly Build 37	7	19,850,092 - 19,850,177	UniSTS
Mouse Cytogenetic Map	7	A3	UniSTS

QTLs in Region (Mouse Genome Assembly Build 37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301352	Bis4_m	beta-carboline induced seizures 4 (mouse)			Not determined		7	17527929	51528044	Mouse
4141790	Hfem1_m	Hfe modifier 1 (mouse)			Not determined		7	14118079	48118215	Mouse
1558790	Mmtp1_m	modifier of mammary tumor progression 1 (mouse)			Not determined		7	14118079	48118215	Mouse
1301041	Prnr2_m	prion resistance 2 (mouse)			Not determined		7	14118079	48118215	Mouse
1301627	Vmbic4_m	ventral midbrain iron content 4 (mouse)			Not determined		7	14118079	48118215	Mouse
1558893	Spir1_m	Streptococcus pneumoniae infection resistance 1 (mouse)			Not determined		7	11391392	45391530	Mouse
1357699	Nhdlq6_m	non-HDL QTL 6 (mouse)			Not determined		7	11074461	45074578	Mouse
1558951	mdlk1_m	modifier of Dlk1 (mouse)			Not determined		7	11074461	45074578	Mouse
1300758	Bomd4_m	bone mineral density 4 (mouse)			Not determined		7	10523163	44523313	Mouse
4142339	Spmd3_m	spermatogenesis defect 3 (mouse)			Not determined		7	10257545	44257688	Mouse
1301572	Sluc30_m	susceptibility to lung cancer 30 (mouse)			Not determined		7	3283120	37283268	Mouse
1300693	Mmtg3_m	modifier of mammary tumor growth 3 (mouse)			Not determined		7	2580218	36580441	Mouse
1558887	Crhr1taq1_m	Crhr1 transcript abundance QTL 1 (mouse)			Not determined		7	1	21955565	Mouse
1558795	Avptaq1_m	Avp transcript abundance QTL 1 (mouse)			Not determined		7	1	21955565	Mouse
1302188	Lxw6_m	lupus BXSB x NZW 6 (mouse)			Not determined		7	1	21646749	Mouse
1301177	Vent3_m	ventricular size 3 (mouse)			Not determined		7	1	20464077	Mouse
1301695	Manz5_m	mandible size 5 (mouse)			Not determined		7	1	20266694	Mouse
1357660	Manln7_m	mandible length 7 (mouse)			Not determined		7	1	20266694	Mouse
1301377	Mprf_m	maternal performance (mouse)			Not determined		7	1	20266694	Mouse

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NM_009499	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHY01059851	(Get FASTA)	Search GEO for Microarray Profiles
	AAHY01059852	(Get FASTA)	Search GEO for Microarray Profiles
	AC148988	(Get FASTA)	Search GEO for Microarray Profiles
	AF084548	(Get FASTA)	Search GEO for Microarray Profiles
	AK140329	(Get FASTA)	Search GEO for Microarray Profiles
	AK150103	(Get FASTA)	Search GEO for Microarray Profiles
	AK155480	(Get FASTA)	Search GEO for Microarray Profiles
	AK157021	(Get FASTA)	Search GEO for Microarray Profiles
	AK170780	(Get FASTA)	Search GEO for Microarray Profiles
	AK171302	(Get FASTA)	Search GEO for Microarray Profiles
	AK171715	(Get FASTA)	Search GEO for Microarray Profiles
	BB850928	(Get FASTA)	Search GEO for Microarray Profiles
	BC010223	(Get FASTA)	Search GEO for Microarray Profiles
	BC015289	(Get FASTA)	Search GEO for Microarray Profiles
	CF582891	(Get FASTA)	Search GEO for Microarray Profiles
	CH466639	(Get FASTA)	Search GEO for Microarray Profiles
	X98475	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_009499

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_033525

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	7	19,256,929 - 19,271,854	-	ENTREZGENE
Mouse cM Map	7		-	ENTREZGENE
Mouse Celera Assembly	7	16,669,928 - 16,684,971	-	RGD
Mouse Genome Assembly Build 37	7	19,842,278 - 19,857,203	-	RGD

Protein Sequences

Protein RefSeqs	NP_033525	(Get FASTA)
GenBank Protein	AAD16045	(Get FASTA)
	AAH10223	(Get FASTA)
	AAH15289	(Get FASTA)
	BAE24338	(Get FASTA)
	BAE29310	(Get FASTA)
	BAE33933	(Get FASTA)
	BAE42025	(Get FASTA)
	BAE42628	(Get FASTA)
	CAA67108	(Get FASTA)
	EDL23127	(Get FASTA)
	EDL23128	(Get FASTA)
	EDL23129	(Get FASTA)
	EDL23130	(Get FASTA)
	EDL23131	(Get FASTA)
	EDL23132	(Get FASTA)
	EDL23133	(Get FASTA)
	P70460	(Get FASTA)

Promoters

RGD ID:

6840422

Promoter ID:

MM_KWN:49043

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, Kidney, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000060547, OTTMUST00000060548

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	7	19,842,921 - 19,843,982	+	MPROMDB

RGD ID:

6842326

Promoter ID:

MM_KWN:49044

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_2Hour, BoneMarrow_4Hour

Transcripts:

OTTMUST00000060546

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	7	19,845,981 - 19,846,682	-	MPROMDB

RGD ID:

6842324

Promoter ID:

MM_KWN:49045

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Kidney, Lung, MEF_B6

Transcripts:

UC009FLD.1

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	7	19,849,926 - 19,851,122	-	MPROMDB

RGD ID:

6842322

Promoter ID:

MM_KWN:49046

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000060545, UC009FLF.1

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	7	19,856,981 - 19,858,007	-	MPROMDB

RGD ID:

6880568

Promoter ID:

EPDNEW_M3735

Type:

preliminary

Name:

Vasp_1

Description:

vasodilator-stimulated phosphoprotein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	7	19,857,170 - 19,857,230		EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000030403	ENTREZGENE
Ensembl Protein	ENSMUSP00000032561	ENTREZGENE
Ensembl Transcript	ENSMUST00000032561	ENTREZGENE
Entrez Gene	22323	ENTREZGENE
Gene3D-CATH	PH_type	UniProtKB/Swiss-Prot
Germonline	ENSMUSG00000030403
HomoloGene Group ID	7592	ENTREZGENE
InterPro	EVH1	UniProtKB/Swiss-Prot
	PH_type	UniProtKB/Swiss-Prot
	Vasodilator_phosphoprotein	UniProtKB/Swiss-Prot
	VASP_tetra	UniProtKB/Swiss-Prot
IPI	IPI00624876	UniProtKB/Swiss-Prot
KEGG Report	mmu:22323	ENTREZGENE, UniProtKB/Swiss-Prot
MGD	MGI:109268	ENTREZGENE
Pfam	VASP_tetra	UniProtKB/Swiss-Prot
	WH1	UniProtKB/Swiss-Prot
PIRSF	Vasodilator_Phospo	UniProtKB/Swiss-Prot
PROSITE	WH1	UniProtKB/Swiss-Prot
SMART	WH1	UniProtKB/Swiss-Prot
UniGene	Mm.9684	ENTREZGENE
UniProt	VASP_MOUSE	UniProtKB/Swiss-Prot

More on Vasp
	Entrez Gene
	Ensembl Gene
	Genome Browser
	MGI Report
	NCBI Map Viewer
	Vista
	Vista + UCSC

RGD Object Information
RGD ID:	1323056
Created:	2005-01-12
Species:	Mus musculus
Last Modified:	2013-02-27
Status:	ACTIVE