KDELR3 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3)

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Keyword

Gene: KDELR3 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3) Homo sapiens

Symbol:

KDELR3

Name:

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

Description:

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ER lumen protein retaining receptor 3; ERD2L3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3; OTTHUMP00000204024; OTTHUMP00000204025

Orthologs:

Mus musculus : Kdelr3 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3) MGI
Rattus norvegicus : Kdelr3 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	22	22,780,935 - 22,796,298	+	NCBI
Human Genome Assembly HuRef	22	21,830,126 - 21,845,485	+	NCBI
Human Genome Assembly GRCh37	22	38,864,083 - 38,879,445	+	NCBI
Human Celera Assembly	22	22,669,670 - 22,685,024	+	NCBI
Human Genome Assembly Build 36	22	37,194,029 - 37,209,391	+	NCBI
Human Cytogenetic Map	22	q13.1		NCBI
Human Genome Assembly	22	37,188,582 - 37,202,138		NCBI