Cst5 (cystatin D) - Rat Genome Database

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Gene: Cst5 (cystatin D) Mus musculus
Analyze
Symbol: Cst5 (Ensembl: Cst10)
Name: cystatin D (Ensembl:cystatin 10 (chondrocytes))
RGD ID: 1322185
MGI Page MGI
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Involved in several processes, including bone mineralization; calcium ion homeostasis; and endochondral bone morphogenesis. Acts upstream of or within cell maturation and chondrocyte differentiation. Located in cytosol. Orthologous to human CST5 (cystatin D).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carminerin; Cst10; cystatin 10; cystatin 10 (chondrocytes); cystatin-D; DD72
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392149,247,242 - 149,252,217 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2149,246,977 - 149,252,213 (+)EnsemblGRCm39 Ensembl
GRCm382149,405,249 - 149,410,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2149,405,057 - 149,410,293 (+)EnsemblGRCm38mm10GRCm38
MGSCv372149,230,985 - 149,236,014 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362149,096,690 - 149,101,719 (+)NCBIMGSCv36mm8
Celera2150,661,381 - 150,663,520 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10713450   PMID:11856874   PMID:12477932   PMID:13679380   PMID:16680148   PMID:18391548   PMID:21873635  


Genomics

Comparative Map Data
Cst5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392149,247,242 - 149,252,217 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2149,246,977 - 149,252,213 (+)EnsemblGRCm39 Ensembl
GRCm382149,405,249 - 149,410,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2149,405,057 - 149,410,293 (+)EnsemblGRCm38mm10GRCm38
MGSCv372149,230,985 - 149,236,014 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362149,096,690 - 149,101,719 (+)NCBIMGSCv36mm8
Celera2150,661,381 - 150,663,520 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.8NCBI
CST5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,875,934 - 23,879,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,875,934 - 23,879,748 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,856,571 - 23,860,385 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,804,572 - 23,808,380 (-)NCBINCBI36Build 36hg18NCBI36
Build 342023,804,792 - 23,808,371NCBI
Celera2023,929,951 - 23,933,759 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,813,604 - 23,817,412 (-)NCBIHuRef
CHM1_12023,856,749 - 23,860,557 (-)NCBICHM1_1
T2T-CHM13v2.02023,935,655 - 23,939,469 (-)NCBIT2T-CHM13v2.0
Cst5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83158,033,791 - 158,038,345 (+)NCBIGRCr8
mRatBN7.23137,573,194 - 137,577,754 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3137,573,194 - 137,577,754 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3141,505,992 - 141,510,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03150,089,686 - 150,094,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03147,806,172 - 147,810,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03144,569,502 - 144,574,112 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3144,569,502 - 144,574,112 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03150,943,493 - 150,948,103 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43138,967,434 - 138,972,106 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13138,873,315 - 139,339,652 (+)NCBI
Celera3136,259,691 - 136,264,235 (+)NCBICelera
Cytogenetic Map3q41NCBI
CST5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,756,245 - 24,760,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12024,753,078 - 24,756,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02023,824,663 - 23,828,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12024,178,197 - 24,182,009 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2024,178,197 - 24,182,016 (-)Ensemblpanpan1.1panPan2
CST5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,015,431 - 53,020,125 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,015,687 - 53,019,336 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605092,820,941 - 92,824,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cst5
170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:96
Interacting mature miRNAs:96
Transcripts:ENSMUST00000047008, ENSMUST00000109938, ENSMUST00000109939
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse

Markers in Region
D2Mit110  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382149,585,526 - 149,585,631UniSTSGRCm38
MGSCv372149,411,262 - 149,411,367UniSTSGRCm37
Cytogenetic Map2G3UniSTS
cM Map283.0UniSTS
Whitehead Genetic268.9UniSTS
Whitehead_YAC2 UniSTS
D2Mit408  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382149,494,735 - 149,494,844UniSTSGRCm38
MGSCv372149,320,471 - 149,320,580UniSTSGRCm37
Celera2150,744,247 - 150,744,356UniSTS
Cytogenetic Map2G3UniSTS
cM Map268.9UniSTS
Whitehead Genetic268.9UniSTS
Whitehead/MRC_RH21759.6UniSTS
Whitehead_YAC2 UniSTS
AU048625  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382149,578,900 - 149,579,058UniSTSGRCm38
MGSCv372149,404,636 - 149,404,794UniSTSGRCm37
Celera2150,821,145 - 150,821,303UniSTS
Cytogenetic Map2G3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047008   ⟹   ENSMUSP00000043520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2149,247,169 - 149,252,213 (+)Ensembl
GRCm38.p6 Ensembl2149,405,249 - 149,410,293 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109938   ⟹   ENSMUSP00000105564
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2149,246,977 - 149,252,213 (+)Ensembl
GRCm38.p6 Ensembl2149,405,057 - 149,410,293 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109939   ⟹   ENSMUSP00000105565
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2149,247,253 - 149,252,213 (+)Ensembl
GRCm38.p6 Ensembl2149,405,333 - 149,410,293 (+)Ensembl
RefSeq Acc Id: NM_021405   ⟹   NP_067380
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392149,247,242 - 149,252,217 (+)NCBI
GRCm382149,405,249 - 149,410,278 (+)ENTREZGENE
MGSCv372149,230,985 - 149,236,014 (+)RGD
Celera2150,661,381 - 150,663,520 (+)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_067380 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH48364 (Get FASTA)   NCBI Sequence Viewer  
  BAA95411 (Get FASTA)   NCBI Sequence Viewer  
  EDL28553 (Get FASTA)   NCBI Sequence Viewer  
  EDL28554 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000043520
  ENSMUSP00000043520.3
  ENSMUSP00000105564.2
  ENSMUSP00000105565.3
GenBank Protein Q9JM84 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_067380   ⟸   NM_021405
- Peptide Label: precursor
- UniProtKB: A2ART7 (UniProtKB/Swiss-Prot),   Q9JM84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000043520   ⟸   ENSMUST00000047008
RefSeq Acc Id: ENSMUSP00000105565   ⟸   ENSMUST00000109939
RefSeq Acc Id: ENSMUSP00000105564   ⟸   ENSMUST00000109938
Protein Domains
Cystatin kininogen-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM84-F1-model_v2 AlphaFold Q9JM84 1-148 view protein structure

Promoters
RGD ID:6879100
Promoter ID:EPDNEW_M2991
Type:multiple initiation site
Name:Cst10_1
Description:Mus musculus cystatin 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382149,405,322 - 149,405,382EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930004 AgrOrtholog
Ensembl Genes ENSMUSG00000033156 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047008 ENTREZGENE
  ENSMUST00000047008.9 UniProtKB/Swiss-Prot
  ENSMUST00000109938.8 UniProtKB/Swiss-Prot
  ENSMUST00000109939.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Cystatin_sf UniProtKB/Swiss-Prot
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot
  Prot_inh_stefin UniProtKB/Swiss-Prot
KEGG Report mmu:58214 UniProtKB/Swiss-Prot
MGD MGI:1930004 ENTREZGENE
NCBI Gene 58214 ENTREZGENE
PANTHER CYSTATIN UniProtKB/Swiss-Prot
  CYSTATIN 10 UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot
PhenoGen Cst5 PhenoGen
PRINTS STEFINA UniProtKB/Swiss-Prot
PROSITE CYSTATIN UniProtKB/Swiss-Prot
SMART SM00043 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot
UniProt A2ART7 ENTREZGENE
  CST10_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2ART7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-02 Cst5  cystatin D  Cst10  cystatin 10 (chondrocytes)  Symbol and/or name updated 27372883 PROVISIONAL