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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | increases expression | ISO | RGD:1321639 | 6480464 | Estradiol results in increased expression of TNFRSF11A mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1321639 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNFRSF11A mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1321639 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNFRSF11A mRNA | CTD | PMID:20106945 PMID:21632981 | 2,6-dinitrotoluene | affects expression | ISO | RGD:1563614 | 6480464 | 2,6-dinitrotoluene affects the expression of TNFRSF11A mRNA | CTD | PMID:21346803 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of TNFRSF11A mRNA | CTD | PMID:18648102 | all-trans-retinoic acid | decreases expression | ISO | RGD:1321639 | 6480464 | Tretinoin results in decreased expression of TNFRSF11A mRNA | CTD | PMID:21934132 | benzo[a]pyrene | increases expression | ISO | RGD:1321639 | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF11A mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:1321639 | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF11A mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | ISO | RGD:1321639 | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF11A mRNA | CTD | PMID:20106945 PMID:22316170 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride co-treated with TNFSF11] results in increased expression of TNFRSF11A mRNA | CTD | PMID:21723911 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF11A mRNA | CTD | PMID:20938992 | cisplatin | increases expression | ISO | RGD:1321639 | 6480464 | Cisplatin results in increased expression of TNFRSF11A mRNA; more ... | CTD | PMID:21278888 | diarsenic trioxide | decreases expression | ISO | RGD:1563614 | 6480464 | arsenic trioxide results in decreased expression of TNFRSF11A mRNA | CTD | PMID:19730151 | diarsenic trioxide | increases expression | ISO | RGD:1321639 | 6480464 | arsenic trioxide results in increased expression of TNFRSF11A mRNA | CTD | PMID:17530438 PMID:22521957 | diarsenic trioxide | decreases expression | ISO | RGD:1321639 | 6480464 | arsenic trioxide results in decreased expression of TNFRSF11A mRNA | CTD | PMID:19769630 | diarsenic trioxide | increases expression | ISO | RGD:1321639 | 6480464 | arsenic trioxide results in increased expression of TNFRSF11A mRNA | CTD | PMID:17530438 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF11A mRNA | CTD | PMID:20938992 | furosemide | affects expression | ISO | RGD:1563614 | 6480464 | Furosemide affects the expression of TNFRSF11A mRNA | CTD | PMID:17497460 | indole-3-methanol | multiple interactions | ISO | RGD:1563614 | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TNFRSF11A mRNA | CTD | PMID:22129741 | isoflurane | decreases expression | ISO | RGD:1563614 | 6480464 | Isoflurane results in decreased expression of TNFRSF11A mRNA | CTD | PMID:16978161 | kaempferol | multiple interactions | EXP | | 6480464 | kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] | CTD | PMID:16434028 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF11A mRNA | CTD | PMID:20938992 | lead diacetate | increases expression | ISO | RGD:1563614 | 6480464 | lead acetate results in increased expression of TNFRSF11A mRNA | CTD | PMID:22641619 | mangiferin | decreases expression | EXP | | 6480464 | mangiferin results in decreased expression of TNFRSF11A mRNA | CTD | PMID:15135318 | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of TNFRSF11A mRNA | CTD | PMID:22401849 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:1563614 | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TNFRSF11A mRNA | CTD | PMID:22129741 | pentobarbital | decreases expression | ISO | RGD:1563614 | 6480464 | Pentobarbital results in decreased expression of TNFRSF11A mRNA | CTD | PMID:16978161 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of TNFRSF11A mRNA | CTD | PMID:17426115 | quercetin | multiple interactions | EXP | | 6480464 | Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] | CTD | PMID:16434028 | quercetin | increases expression | ISO | RGD:1321639 | 6480464 | Quercetin results in increased expression of TNFRSF11A mRNA | CTD | PMID:21632981 | raloxifene | decreases expression | ISO | RGD:1321639 | 6480464 | Raloxifene results in decreased expression of TNFRSF11A mRNA | CTD | PMID:16005483 | resveratrol | multiple interactions | ISO | RGD:1321639 | 6480464 | resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A mRNA]; more ... | CTD | PMID:16267019 | rosiglitazone | multiple interactions | EXP | | 6480464 | rosiglitazone inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]; more ... | CTD | PMID:22286232 | titanium atom | increases expression | ISO | RGD:1321639 | 6480464 | Titanium results in increased expression of TNFRSF11A mRNA | CTD | PMID:18449944 | trans-resveratrol | multiple interactions | ISO | RGD:1321639 | 6480464 | resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A mRNA]; more ... | CTD | PMID:16267019 | valproic acid | increases expression | ISO | RGD:1321639 | 6480464 | Valproic Acid results in increased expression of TNFRSF11A mRNA | CTD | PMID:19101580 | zinc atom | decreases expression | ISO | RGD:1563614 | 6480464 | Zinc deficiency results in decreased expression of TNFRSF11A mRNA; more ... | CTD | PMID:21893222 | zinc(0) | decreases expression | ISO | RGD:1563614 | 6480464 | Zinc deficiency results in decreased expression of TNFRSF11A mRNA; more ... | CTD | PMID:21893222 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| NF-kappa B signaling pathway | |
| Osteoclast differentiation | |
| Rheumatoid arthritis | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| NF-kappa B signaling pathway | |
| Osteoclast differentiation | |
| Rheumatoid arthritis | |
Phenotype Annotations
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References - curated| 1. |
Chen G, etal., Cancer. 2006 Jul 15;107(2):289-98. |
| 2. |
de Amorim FP, etal., J Mol Histol. 2008 Aug;39(4):401-8. Epub 2008 Jul 1. |
| 3. |
Hughes AE, etal., Nat Genet. 2000 Jan;24(1):45-8. |
| 4. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 5. |
Lerebours F, etal., BMC Cancer. 2008 Feb 4;8:41. |
| 6. |
Liu W, etal., Exp Mol Pathol. 2008 Jun;84(3):213-7. Epub 2008 Mar 7. |
| 7. |
MGD data from the GO Consortium |
| 8. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 9. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 10. |
RGD automated import pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
RGD Automated Pipelines |
| 13. |
Siddiqui IA, etal., Pharm Res. 2008 Mar 4;. |
| 14. |
Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95. |
References - uncurated| PubMed | 10097072 |
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RGD Disease Portals| Tnfrsf11a has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tnfrsf11a (Mus musculus) |
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| TNFRSF11A (Homo sapiens) |
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| Tnfrsf11a (Rattus norvegicus) |
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Position Markers| AF019046 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_009399 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01009320 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01009321 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01009322 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01009323 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01009324 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC101816 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF019046 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK020374 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK042798 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK138990 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC019185 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466520 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GM986873 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_009399 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_033425 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_033425 | (Get FASTA) |
| GenBank Protein | AAB86810 | (Get FASTA) |
| AAH19185 | (Get FASTA) | |
| CAX21651 | (Get FASTA) | |
| EDL39871 | (Get FASTA) | |
| O35305 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000026321 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000027559 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000027559 | ENTREZGENE |
| Entrez Gene | 21934 | ENTREZGENE |
| Germonline | ENSMUSG00000026321 | |
| HomoloGene Group ID | 2848 | ENTREZGENE |
| InterPro | TNFR_11 | UniProtKB/Swiss-Prot |
| TNFR_11A | UniProtKB/Swiss-Prot | |
| TNFR_Cys_rich_reg | UniProtKB/Swiss-Prot | |
| IPI | IPI00129631 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:21934 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1314891 | ENTREZGENE |
| Pfam | TNFR_c6 | UniProtKB/Swiss-Prot |
| PRINTS | TNFACTORR11 | UniProtKB/Swiss-Prot |
| TNFACTORR11A | UniProtKB/Swiss-Prot | |
| PROSITE | TNFR_NGFR_1 | UniProtKB/Swiss-Prot |
| TNFR_NGFR_2 | UniProtKB/Swiss-Prot | |
| SMART | TNFR | UniProtKB/Swiss-Prot |
| UniGene | Mm.6251 | ENTREZGENE |
| UniProt | TNR11_MOUSE | UniProtKB/Swiss-Prot |
| More on Tnfrsf11a | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1321640 |
| Created: | 2005-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




