Gene: SRF (serum response factor (c-fos serum response element-binding transcription factor))
Homo sapiens
Symbol:
SRF
Name:
serum response factor (c-fos serum response element-binding transcription factor)
Description:
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
MCM1; OTTHUMP00000016422; serum response factor
Orthologs:
Mus musculus : Srf
(serum response factor)
MGI
Srf
(serum response factor (c-fos serum response element-binding transcription factor))
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 6 43,049,845 - 43,060,171 + NCBI Human Genome Assembly HuRef 6 42,855,575 - 42,865,934 + NCBI Human Genome Assembly GRCh37 6 43,138,920 - 43,149,244 + NCBI Human Genome Assembly Build 36 6 43,246,898 - 43,257,222 + NCBI Human Cytogenetic Map 6 p21.1 NCBI Human Genome Assembly 6 43,247,014 - 43,257,221 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
(-)-anisomycin increases phosphorylation EXP 6480464 Anisomycin results in increased phosphorylation of SRF protein CTD PMID:12660819 (-)-anisomycin multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein] CTD PMID:12660819 (S)-amphetamine multiple interactions ISO RGD:1559787 6480464 [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; more ... CTD PMID:12510024 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SRF mRNA CTD PMID:23146750 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1559787 6480464 Tetrachlorodibenzodioxin affects the expression of SRF mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1321394 6480464 Tetrachlorodibenzodioxin affects the expression of SRF mRNA CTD PMID:21570461 2-butoxyethanol increases expression ISO RGD:1321394 6480464 n-butoxyethanol results in increased expression of SRF mRNA CTD PMID:19812364 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of SRF mRNA CTD PMID:21179406 benzo[a]pyrene decreases expression ISO RGD:1321394 6480464 Benzo(a)pyrene results in decreased expression of SRF mRNA CTD PMID:21715664 benzo[a]pyrene increases expression ISO RGD:1559787 6480464 Benzo(a)pyrene results in increased expression of SRF protein CTD PMID:21467743 benzo[a]pyrene increases expression ISO RGD:1321394 6480464 Benzo(a)pyrene results in increased expression of SRF mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:1321394 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SRF mRNA] CTD PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:1321394 6480464 Benzo(a)pyrene results in decreased expression of SRF mRNA CTD PMID:19770486 more ... benzo[a]pyrene decreases expression ISO RGD:1321394 6480464 Benzo(a)pyrene results in decreased expression of SRF mRNA CTD PMID:19770486 PMID:21715664 benzo[a]pyrene decreases expression ISO RGD:1321394 6480464 Benzo(a)pyrene results in decreased expression of SRF mRNA CTD PMID:21715664 PMID:19770486 benzo[a]pyrene affects activity EXP 6480464 Benzo(a)pyrene affects the activity of SRF protein CTD PMID:20624995 C60 fullerene decreases expression ISO RGD:1559787 6480464 fullerene C60 results in decreased expression of SRF mRNA CTD PMID:19167457 cadmium sulfate multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA CTD PMID:18654764 chlorpyrifos increases expression ISO RGD:1559787 6480464 Chlorpyrifos results in increased expression of SRF mRNA CTD PMID:20691718 chlorpyrifos decreases expression ISO RGD:1559787 6480464 Chlorpyrifos results in decreased expression of SRF mRNA CTD PMID:18668222 cobalt dichloride multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA CTD PMID:18654764 diarsenic trioxide decreases expression EXP 6480464 arsenic trioxide results in decreased expression of SRF mRNA CTD PMID:20458559 dibutyl phthalate increases expression ISO RGD:1321394 6480464 Dibutyl Phthalate results in increased expression of SRF mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:1321394 6480464 Dibutyl Phthalate results in increased expression of SRF mRNA CTD PMID:17361019 PMID:21266533 dibutyl phthalate increases expression ISO RGD:1559787 6480464 Dibutyl Phthalate results in increased expression of SRF mRNA CTD PMID:21266533 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of SRF mRNA CTD PMID:12419474 leflunomide decreases expression ISO RGD:1321394 6480464 leflunomide results in decreased expression of SRF mRNA CTD PMID:19751817 mangiferin decreases expression ISO RGD:1321394 6480464 mangiferin results in decreased expression of SRF mRNA CTD PMID:15135318 mercury atom decreases expression EXP 6480464 Mercury results in decreased expression of SRF mRNA CTD PMID:16823088 mercury(0) decreases expression EXP 6480464 Mercury results in decreased expression of SRF mRNA CTD PMID:16823088 paracetamol affects expression ISO RGD:1321394 6480464 Acetaminophen affects the expression of SRF mRNA CTD PMID:17562736 phencyclidine multiple interactions ISO RGD:1559787 6480464 [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; more ... CTD PMID:12510024 resveratrol decreases expression ISO RGD:1559787 6480464 resveratrol results in decreased expression of SRF mRNA CTD PMID:20797428 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of SRF mRNA CTD PMID:12419474 trans-resveratrol decreases expression ISO RGD:1559787 6480464 resveratrol results in decreased expression of SRF mRNA CTD PMID:20797428 trichloroethene increases expression ISO RGD:1559787 6480464 Trichloroethylene results in increased expression of SRF mRNA CTD PMID:14565619 trimethyltin decreases expression ISO RGD:1321394 6480464 trimethyltin results in decreased expression of SRF mRNA CTD PMID:21435392
2289164 BW111_H Body weight QTL 111 (human) .002 Body fat amount percent fat 6 18540451 44540451 Human 2289194 BW353_H Body weight QTL 353 (human) .012 Body fat amount percent fat 6 18540451 44540451 Human 2289175 BW112_H Body weight QTL 112 (human) .048 Body fat amount percent fat 6 18683815 44683815 Human 1358839 MULTSCL5_H Multiple sclerosis susceptibility QTL 5 (human) Multiple sclerosis susceptibility 6 19552079 45552079 Human 1358857 MULTSCL19_H Multiple sclerosis susceptibility QTL 19 (human) Multiple sclerosis susceptibility 6 19552079 45552079 Human 1559135 LDLPS2_H Low density lipoprotein particle size QTL 2 (human) 4.1 LDL particle size 3 23001248 49001248 Human 1357292 AASTH34_H Allergic/atopic asthma related QTL 34 (human) 2.61 Atopy reversible airflow obstruction 6 23265619 49265619 Human 2289170 BW113_H Body weight QTL 113 (human) .018 Body fat amount percent fat 6 23265619 49265619 Human 2292786 PRSTS7_H Prostate tumor susceptibility QTL 7 (human) Prostate tumor susceptibility late onset 6 28677275 54677275 Human 1298490 OSTEAR22_H Osteoarthritis QTL 22 (human) 2.9 Joint/bone inflammation hip osteoarthritis 6 39259604 140014781 Human 1298473 RA12_H Rheumatoid arthritis QTL 12 (human) .0043 Joint/bone inflammation rheumatoid arthritis 6 39475357 65475357 Human 2289587 BW467_H Body weight QTL 467 (human) 2.4 Body fat amount percent fat 6 40642207 131730853 Human 1298438 BP4_H Blood pressure QTL 4 (human) 2.5 Blood pressure diastolic 6 41677196 104674060 Human 1559247 SCL51_H Serum cholesterol level QTL 51 (human) 1.95 Lipid level LDL cholesterol 6 42918664 68918664 Human 1559254 SCL57_H Serum cholesterol level QTL 57 (human) 2 Lipid level LDL cholesterol and triglyceride 6 43098859 73745672 Human
Gene-Chemical Interaction Annotations
