Alx4 (aristaless-like homeobox 4) - Rat Genome Database

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Gene: Alx4 (aristaless-like homeobox 4) Mus musculus
Analyze
Symbol: Alx4
Name: aristaless-like homeobox 4
RGD ID: 1320964
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; embryonic skeletal system morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; integumental system; and sensory organ. Used to study parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis; frontonasal dysplasia 2; gastrointestinal system cancer (multiple); lung cancer (multiple); and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALX-4; aristaless 4; Aristaless-like 4; homeobox protein aristaless-like 4; lst; Strong's luxoid
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,472,779 - 93,511,686 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,472,729 - 93,511,684 (+)EnsemblGRCm39 Ensembl
GRCm38293,642,434 - 93,681,341 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl293,642,384 - 93,681,339 (+)EnsemblGRCm38mm10GRCm38
MGSCv37293,482,591 - 93,521,496 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36293,443,273 - 93,478,775 (+)NCBIMGSCv36mm8
Celera295,046,101 - 95,085,009 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal lateral nasal prominence morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal maxillary frontal process morphology  (IAGP)
abnormal medial nasal prominence morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal cavity morphology  (IAGP)
abnormal nasal septum cartilage morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal pterygoid process morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal scapular spine morphology  (IAGP)
abnormal viscerocranium morphology  (IAGP)
abnormal zone of polarizing activity morphology  (IAGP)
absent clavicle  (IAGP)
absent deltoid tuberosity  (IAGP)
absent facial bone  (IAGP)
absent gastric milk in neonates  (IAGP)
absent nasal septum  (IAGP)
absent pubis  (IAGP)
alopecia  (IAGP)
asymmetric rib joints  (IAGP)
bifid nasal tip  (IAGP)
bifid nose  (IAGP)
broad nasal bridge  (IAGP)
cataract  (IAGP)
cleft palate  (IAGP)
decreased cranium height  (IAGP)
decreased rib number  (IAGP)
delayed hair appearance  (IEA)
depressed nasal bridge  (IAGP)
exencephaly  (IAGP)
exophthalmos  (IAGP)
eyelids open at birth  (IAGP)
failure of eyelid fusion  (IAGP)
focal dorsal hair loss  (IEA)
herniated abdominal wall  (IAGP)
increased cranium width  (IAGP)
large fontanelles  (IAGP)
meteorism  (IAGP)
midline cleft upper lip  (IAGP)
midline facial cleft  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
omphalocele  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polydactyly  (IAGP)
preaxial polydactyly  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
short facial bone  (IAGP)
short mandible  (IAGP)
short philtrum  (IAGP)
short snout  (IAGP)
short temporal bone squamous part  (IAGP)
short tibia  (IAGP)
small acromion  (IAGP)
small alisphenoid bone  (IAGP)
small frontal bone  (IAGP)
small mandible  (IAGP)
small nasal bone  (IAGP)
small occipital bone  (IAGP)
small parietal bone  (IAGP)
small pubis  (IAGP)
small scapula  (IAGP)
small temporal bone  (IAGP)
split sternum  (IAGP)
thin skin  (IAGP)
upturned snout  (IEA)
References

References - curated
# Reference Title Reference Citation
1. AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. Albertus DL, etal., J Thorac Oncol. 2008 Nov;3(11):1236-44. doi: 10.1097/JTO.0b013e318189f5ec.
2. Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas. Ebert MP, etal., Gastroenterology. 2006 Nov;131(5):1418-30. doi: 10.1053/j.gastro.2006.08.034. Epub 2006 Aug 18.
3. Differential expression of aristaless-like homeobox 4: a potential marker for gastric adenocarcinoma. Ghasemvand F, etal., Gastroenterol Hepatol Bed Bench. 2016 Fall;9(4):286-294.
4. Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer. Liu WB, etal., Int J Cancer. 2014 Mar 15;134(6):1311-22. doi: 10.1002/ijc.28472. Epub 2013 Nov 11.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Methylation pattern of ALX4 gene promoter as a potential biomarker for blood-based early detection of colorectal cancer. Salehi R, etal., Adv Biomed Res. 2015 Nov 30;4:252. doi: 10.4103/2277-9175.170677. eCollection 2015.
12. Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells. Shi Y, etal., Oncol Res. 2017 Jan 2;25(1):11-18. doi: 10.3727/096504016X14685034103833.
13. Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions. Tänzer M, etal., PLoS One. 2010 Feb 4;5(2):e9061. doi: 10.1371/journal.pone.0009061.
14. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Yada Y, etal., Int J Dev Biol 2002;46(7):975-82.
15. Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway. Zhao J, etal., Sci Total Environ. 2019 Sep 15;683:317-330. doi: 10.1016/j.scitotenv.2019.05.144. Epub 2019 May 15.
Additional References at PubMed
PMID:124471   PMID:1018005   PMID:5480943   PMID:5759552   PMID:7517224   PMID:7635045   PMID:8595881   PMID:8792607   PMID:9073443   PMID:9152005   PMID:9268572   PMID:9272948  
PMID:9374397   PMID:9426253   PMID:9545497   PMID:9636085   PMID:9778501   PMID:9786416   PMID:9847249   PMID:10518490   PMID:10668975   PMID:10673281   PMID:10753507   PMID:10969736  
PMID:11017806   PMID:11518254   PMID:11518511   PMID:11520673   PMID:11641221   PMID:11696550   PMID:11850405   PMID:12086465   PMID:12124942   PMID:12142027   PMID:12152071   PMID:12183386  
PMID:12193642   PMID:12215652   PMID:12399319   PMID:12413903   PMID:12477932   PMID:13894155   PMID:14079603   PMID:14512019   PMID:14681479   PMID:14727139   PMID:15162501   PMID:15198690  
PMID:15385160   PMID:15581864   PMID:15618518   PMID:15728667   PMID:15930102   PMID:15936012   PMID:15968591   PMID:16039644   PMID:16120640   PMID:16207751   PMID:16221728   PMID:16537572  
PMID:16582099   PMID:16602821   PMID:16672333   PMID:16892173   PMID:16916507   PMID:16960803   PMID:17151600   PMID:17588959   PMID:17964566   PMID:18287559   PMID:18359901   PMID:18422524  
PMID:18572160   PMID:18579682   PMID:18634775   PMID:19168678   PMID:19211672   PMID:19248778   PMID:19386268   PMID:19386269   PMID:19414008   PMID:19422820   PMID:19785007   PMID:20059953  
PMID:20211142   PMID:20386744   PMID:20501333   PMID:20534379   PMID:20627960   PMID:20732316   PMID:20932939   PMID:21122108   PMID:21267068   PMID:21283718   PMID:21309073   PMID:21455939  
PMID:21795281   PMID:21873635   PMID:22178153   PMID:22275192   PMID:22438573   PMID:22841643   PMID:22988430   PMID:23201021   PMID:23473983   PMID:23942202   PMID:23979902   PMID:24086166  
PMID:24146773   PMID:24218595   PMID:24415953   PMID:24424161   PMID:24639464   PMID:24726282   PMID:24726283   PMID:24952961   PMID:25448692   PMID:25581370   PMID:25673119   PMID:25760946  
PMID:26234751   PMID:26238476   PMID:26959361   PMID:27352137   PMID:28931923   PMID:29028795   PMID:29475039   PMID:29729398   PMID:30638444   PMID:30786278   PMID:30905259   PMID:31896583  
PMID:32169905   PMID:32913205   PMID:33304758   PMID:33728725   PMID:34254395   PMID:34822715   PMID:34928956   PMID:35127681   PMID:35781558   PMID:38063857   PMID:38404688  


Genomics

Comparative Map Data
Alx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,472,779 - 93,511,686 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,472,729 - 93,511,684 (+)EnsemblGRCm39 Ensembl
GRCm38293,642,434 - 93,681,341 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl293,642,384 - 93,681,339 (+)EnsemblGRCm38mm10GRCm38
MGSCv37293,482,591 - 93,521,496 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36293,443,273 - 93,478,775 (+)NCBIMGSCv36mm8
Celera295,046,101 - 95,085,009 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
ALX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381144,260,440 - 44,310,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1144,260,440 - 44,310,139 (-)EnsemblGRCh38hg38GRCh38
GRCh371144,281,990 - 44,331,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,242,734 - 44,288,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,242,733 - 44,288,292NCBI
Celera1144,429,565 - 44,479,005 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1143,991,253 - 44,040,694 (-)NCBIHuRef
CHM1_11144,281,300 - 44,330,733 (-)NCBICHM1_1
T2T-CHM13v2.01144,415,783 - 44,465,465 (-)NCBIT2T-CHM13v2.0
Alx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,067,052 - 100,103,624 (+)NCBIGRCr8
mRatBN7.2379,611,682 - 79,648,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,611,719 - 79,648,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,085,796 - 83,122,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0391,684,866 - 91,721,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,536,444 - 89,573,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,548,959 - 82,585,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,548,959 - 82,585,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,249,541 - 89,286,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,057,714 - 78,094,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1377,954,190 - 77,990,612 (+)NCBI
Celera378,814,063 - 78,850,575 (+)NCBICelera
Cytogenetic Map3q31NCBI
Alx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554223,278,615 - 3,291,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554223,278,615 - 3,290,799 (+)NCBIChiLan1.0ChiLan1.0
ALX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2946,474,416 - 46,524,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11146,464,895 - 46,530,312 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01144,219,865 - 44,269,597 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11144,714,503 - 44,729,758 (-)NCBIpanpan1.1PanPan1.1panPan2
ALX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11844,922,042 - 44,967,557 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1844,922,150 - 44,967,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,590,411 - 43,635,910 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,583,479 - 45,629,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,583,532 - 45,629,081 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,066,662 - 45,112,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,620,210 - 44,665,671 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,356,336 - 45,401,930 (+)NCBIUU_Cfam_GSD_1.0
Alx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494722,204,908 - 22,218,129 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365624,314,870 - 4,326,000 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365624,316,550 - 4,326,022 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,037,401 - 18,085,683 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,070,726 - 18,085,685 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2219,626,044 - 19,627,294 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,051,413 - 21,099,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,051,580 - 21,097,605 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038118,279,875 - 118,329,166 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247673,770,762 - 3,805,323 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247673,770,755 - 3,808,511 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alx4
1243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4793
Count of miRNA genes:855
Interacting mature miRNAs:1176
Transcripts:ENSMUST00000042078, ENSMUST00000111254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse

Markers in Region
AF001465  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38293,677,751 - 93,677,849UniSTSGRCm38
MGSCv37293,517,908 - 93,518,006UniSTSGRCm37
Celera295,081,375 - 95,081,473UniSTS
Cytogenetic Map2E1UniSTS
cM Map252.0UniSTS
Whitehead/MRC_RH21288.47UniSTS
Alx4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38293,678,261 - 93,679,032UniSTSGRCm38
Celera295,081,885 - 95,082,656UniSTS
Cytogenetic Map2E1UniSTS
cM Map252.0UniSTS
cM Map252.0UniSTS
Alx4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS
cM Map252.0UniSTS
Alx4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042078   ⟹   ENSMUSP00000047962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl293,472,729 - 93,511,684 (+)Ensembl
GRCm38.p6 Ensembl293,642,384 - 93,681,339 (+)Ensembl
RefSeq Acc Id: ENSMUST00000111254   ⟹   ENSMUSP00000106885
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl293,472,733 - 93,511,684 (+)Ensembl
GRCm38.p6 Ensembl293,642,388 - 93,681,339 (+)Ensembl
RefSeq Acc Id: NM_007442   ⟹   NP_031468
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39293,472,779 - 93,511,684 (+)NCBI
GRCm38293,642,434 - 93,681,339 (+)NCBI
MGSCv37293,482,591 - 93,521,496 (+)RGD
Celera295,046,101 - 95,085,009 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_374395
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39293,472,811 - 93,511,686 (+)NCBI
GRCm38293,642,466 - 93,681,341 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_031468 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC39943 (Get FASTA)   NCBI Sequence Viewer  
  EDL27628 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047962
  ENSMUSP00000047962.4
  ENSMUSP00000106885.2
GenBank Protein O35137 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_031468   ⟸   NM_007442
- UniProtKB: O35137 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106885   ⟸   ENSMUST00000111254
RefSeq Acc Id: ENSMUSP00000047962   ⟸   ENSMUST00000042078
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35137-F1-model_v2 AlphaFold O35137 1-399 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108359 AgrOrtholog
Ensembl Genes ENSMUSG00000040310 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000042078 ENTREZGENE
  ENSMUST00000042078.10 UniProtKB/Swiss-Prot
  ENSMUST00000111254.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR_dom UniProtKB/Swiss-Prot
KEGG Report mmu:11695 UniProtKB/Swiss-Prot
MGD MGI:108359 ENTREZGENE
NCBI Gene 11695 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ARISTALESS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24329:SF322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot
PhenoGen Alx4 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AIK5_MOUSE UniProtKB/TrEMBL
  ALX4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE