Gene: ARPC4 (actin related protein 2/3 complex, subunit 4, 20kDa)
Homo sapiens
Symbol:
ARPC4
Name:
actin related protein 2/3 complex, subunit 4, 20kDa
Description:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
actin-related protein 2/3 complex subunit 4; ARC20; arp2/3 complex 20 kDa subunit; Arp2/3 protein complex subunit p20; arp2/3 protein complex subunit p20; MGC13544; OTTHUMP00000165252; OTTHUMP00000207518; OTTHUMP00000207520; OTTHUMP00000233907; p20-Arc; P20-ARC
Orthologs:
Mus musculus : Arpc4
(actin related protein 2/3 complex, subunit 4)
MGI
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 3 9,768,877 - 9,783,485 + NCBI Human Genome Assembly HuRef 3 9,770,526 - 9,785,132 + NCBI Human Genome Assembly GRCh37 3 9,834,179 - 9,848,789 + NCBI Human Genome Assembly Build 36 3 9,809,227 - 9,823,789 + NCBI Human Cytogenetic Map 3 p25.3 NCBI Human Genome Assembly 3 9,809,733 - 9,823,784 NCBI
Model
Gene Ontology Annotations
Biological Process actin filament polymerization IEA InterPro:IPR008384 2290271 GO_REF:0000002 InterPro GO_REF:0000002 actin nucleation NAS 2290271 PMID:11162547 UniProtKB PMID:11162547 Arp2/3 complex-mediated actin nucleation IEA InterPro:IPR008384 2290271 GO_REF:0000002 InterPro GO_REF:0000002 Fc-gamma receptor signaling pathway involved in phagocytosis TAS 2290271 Reactome:REACT_160123 Reactome Reactome:REACT_160123 innate immune response TAS 2290271 Reactome:REACT_6802 Reactome Reactome:REACT_6802
1559253 SCL83_H Serum cholesterol level QTL 83 (human) 1.8 Lipid level HDL cholesterol subfraction 3 3 1 14036366 Human 2289318 BW377_H Body weight QTL 377 (human) 2.16 .0008 Body fat amount abdominal 3 1 14036366 Human 2289503 BW443_H Body weight QTL 443 (human) 3.7 Body weight BMI 3 1 14036366 Human 2289518 BW454_H Body weight QTL 454 (human) 3.19 Body fat amount subcutaneous 3 1 14036366 Human 2314747 GLUCO72_H Glucose level QTL 72 (human) 1.3 .011 Glucose level non-insulin dependent 3 1 14448363 Human 2293390 PRSTS200_H Prostate tumor susceptibility QTL 200 (human) 2.44 Prostate tumor susceptibility 3 1 15038567 Human 2301175 PRSTS361_H Prostate tumor susceptibility QTL 361 (human) 2.46 Prostate tumor susceptibility 3 1 15038567 Human 2301184 PRSTS366_H Prostate tumor susceptibility QTL 366 (human) 2.57 Prostate tumor susceptibility 3 1 15038567 Human 2302774 MAMTS13_H Mammary tumor susceptibility QTL 13 (human) .034 Mammary tumor susceptibility 3 1 16296633 Human 2292850 MYI18_H Myocardial infarction susceptibility QTL 18 (human) Myocardial infarction susceptibility early-onset 3 1 17313192 Human 1643415 BW272_H Body Weight QTL 272 (human) 1.8 .002 Body weight 3 1 19919421 Human 1559349 SCL88_H Serum cholesterol level QTL 88 (human) 1.67 .003 Lipid level total cholesterol 3 1 24517367 Human 1559363 SCL87_H Serum cholesterol level QTL 87 (human) 2.47 .0004 Lipid level LDL cholesterol 3 1 24517367 Human 1300011 BW24_H Body weight QTL 24 (human) 2.03 Body weight body mass index 3 1 25098826 Human 1298439 BP30_H Blood pressure QTL 30 (human) 2.03 Blood pressure systolic 3 1 32165375 Human 1643372 BW336_H Body weight QTL 336 (human) 2.2 Body fat amount percent body fat 3 172530 26172530 Human 2289256 BW95_H Body weight QTL 95 (human) 1.61 .0032 Body fat amount percent fat 3 704334 26704334 Human 1643090 BW152_H Body weight QTL 152 (human) .0112 Body fat amount percent body fat 3 2819327 28819327 Human 1298511 RA3_H Rheumatoid arthritis QTL 3 (human) .0139 Joint/bone inflammation rheumatoid arthritis 3 8949604 34949604 Human 1643540 GLUCO17_H Glucose level QTL 17 (human) .007 Glucose level non-insulin-dependent 3 8949604 34949604 Human
Gene Ontology Annotations
