Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (2,4,5-trichlorophenoxy)acetic acid | decreases expression | EXP | | 6480464 | 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA | CTD | PMID:18579281 | 17beta-estradiol | increases expression | ISO | RGD:1319638 | 6480464 | Estradiol results in increased expression of SEMA3C mRNA | CTD | PMID:19167446 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1319638 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEMA3C mRNA | CTD | PMID:19901195 PMID:19684285 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEMA3C mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1319638 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEMA3C mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1319638 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEMA3C mRNA | CTD | PMID:19684285 PMID:19901195 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SEMA3C mRNA | CTD | PMID:19684285 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1319638 | 6480464 | Fenretinide results in increased expression of SEMA3C mRNA | CTD | PMID:15958647 | afimoxifene | increases expression | ISO | RGD:1319638 | 6480464 | 4-hydroxytamoxifen results in increased expression of SEMA3C mRNA | CTD | PMID:19901195 | aflatoxin B1 | affects expression | ISO | RGD:1319638 | 6480464 | Aflatoxin B1 affects the expression of SEMA3C protein | CTD | PMID:20106945 | all-trans-retinoic acid | increases expression | ISO | RGD:1319638 | 6480464 | Tretinoin results in increased expression of SEMA3C mRNA | CTD | PMID:21934132 | arsenic atom | decreases expression | EXP | | 6480464 | Arsenic results in decreased expression of SEMA3C mRNA | CTD | PMID:19654921 | cadmium dichloride | affects expression | ISO | RGD:1309343 | 6480464 | Cadmium Chloride affects the expression of SEMA3C mRNA | CTD | PMID:22110744 | calcitriol | decreases expression | ISO | RGD:1319638 | 6480464 | Calcitriol results in decreased expression of SEMA3C mRNA | CTD | PMID:15951637 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA3C mRNA | CTD | PMID:20938992 | cobalt dichloride | decreases expression | ISO | RGD:1319638 | 6480464 | cobaltous chloride results in decreased expression of SEMA3C mRNA | CTD | PMID:19376846 | cocaine | affects expression | ISO | RGD:1309343 | 6480464 | Cocaine affects the expression of SEMA3C mRNA | CTD | PMID:15691709 | copper(2+) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of SEMA3C mRNA | CTD | PMID:18579281 | coumestrol | increases expression | ISO | RGD:1319638 | 6480464 | Coumestrol results in increased expression of SEMA3C mRNA | CTD | PMID:19167446 | diuron | decreases expression | ISO | RGD:1309343 | 6480464 | Diuron results in decreased expression of SEMA3C mRNA | CTD | PMID:21551480 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA3C mRNA | CTD | PMID:20938992 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA3C mRNA | CTD | PMID:20938992 | N-ethyl-N-nitrosourea | increases mutagenesis | EXP | | 6480464 | Ethylnitrosourea results in increased mutagenesis of SEMA3C gene | CTD | PMID:15548583 | quercetin | decreases expression | ISO | RGD:1319638 | 6480464 | Quercetin results in decreased expression of SEMA3C mRNA | CTD | PMID:19729006 | sirolimus | multiple interactions | ISO | RGD:1319638 | 6480464 | Sirolimus inhibits the reaction [TP73 protein results in increased expression of SEMA3C mRNA] | CTD | PMID:21245298 | tamoxifen | affects expression | ISO | RGD:1319638 | 6480464 | Tamoxifen affects the expression of SEMA3C mRNA | CTD | PMID:14699072 | troglitazone | increases expression | ISO | RGD:1319638 | 6480464 | troglitazone results in increased expression of SEMA3C mRNA | CTD | PMID:19140230 | vancomycin | decreases expression | EXP | | 6480464 | Vancomycin results in decreased expression of SEMA3C mRNA | CTD | PMID:18930951 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
Phenotype Annotations
Disease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
Phenotype Annotations
|
|
|
References - curated| 1. |
Cloutier JF, etal., Neuron 2002 Mar 14;33(6):877-92. |
| 2. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 3. |
Mangasser-Stephan K, etal., Biochem Biophys Res Commun. 1997 May 8;234(1):153-6. |
| 4. |
MGD data from the GO Consortium |
| 5. |
MGD IEA |
| 6. |
Miller LE, etal., Arthritis Rheum. 2004 Apr;50(4):1156-63. |
| 7. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 8. |
RGD automated import pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated| PubMed | 10349636 |
| 10725249 | |
| 10843805 | |
| 10922068 | |
| 11042159 | |
| 11076861 | |
| 11231073 | |
| 11442635 | |
| 11688556 | |
| 11688557 | |
| 12397112 | |
| 12397115 | |
| 12413905 | |
| 12435358 | |
| 12477932 | |
| 12506007 | |
| 12852851 | |
| 14622119 | |
| 14681479 | |
| 15051154 | |
| 15070745 | |
| 15229182 | |
| 15239958 | |
| 15328020 | |
| 15545635 | |
| 15548583 | |
| 15550623 | |
| 15582152 | |
| 15609325 | |
| 15841179 | |
| 15869472 | |
| 16141072 | |
| 16141073 | |
| 16284245 | |
| 16360650 | |
| 16557299 | |
| 16602821 | |
| 16766700 | |
| 16940438 | |
| 17021275 | |
| 17145500 | |
| 17626059 | |
| 17942483 | |
| 18287559 | |
| 18480165 | |
| 18489001 | |
| 18583714 | |
| 18617019 | |
| 18723443 | |
| 18830417 | |
| 19509466 | |
| 19587446 | |
| 19666519 | |
| 19812329 | |
| 19855134 | |
| 19859539 | |
| 20006658 | |
| 20018673 | |
| 21157040 | |
| 21440680 | |
| 21658587 | |
| 21677750 | |
| 21779340 | |
| 21784065 | |
| 21905163 | |
| 21966449 | |
| 22076636 | |
| 22082309 | |
| 22092651 | |
| 22242143 | |
| 22365545 | |
| 22514301 | |
| 23063659 | |
| 7748561 | |
| 8812066 | |
| 8817451 | |
| 8889548 | |
| 9331348 | |
| 9753685 | |
| 9811588 |
RGD Disease Portals| Sema3c has been annotated in the following RGD Disease Portals. |
|||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
Comparative Map Data| Sema3c (Mus musculus) |
|
||||||||||||||||||||||||||||||||||||||||
| SEMA3C (Homo sapiens) |
|
||||||||||||||||||||||||||||||||||||||||
| Sema3c (Rattus norvegicus) |
|
Position Markers| Sema3c |
|
||||||||||||||||||||||||||||||||||||||||
| UniSTS:235133 |
|
||||||||||||||||||||||||||||||||||||||||
| D5Mit1 |
|
||||||||||||||||||||||||||||||||||||||||
| Sema3c |
|
||||||||||||||||||||||||||||||||||||||||
| Sema3c |
|
||||||||||||||||||||||||||||||||||||||||
| Sema3c |
|
||||||||||||||||||||||||||||||||||||||||
| Sema3c |
|
QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013657 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01042494 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01042495 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01042496 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01042497 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01042498 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC122936 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC161507 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF164783 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK004119 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK034239 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK077231 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK078589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK140348 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC066852 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466586 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X85994 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013657 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_038685 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_038685 | (Get FASTA) |
| GenBank Protein | AAH66852 | (Get FASTA) |
| BAC28643 | (Get FASTA) | |
| BAE24348 | (Get FASTA) | |
| CAA59986 | (Get FASTA) | |
| EDL03233 | (Get FASTA) | |
| EDL03234 | (Get FASTA) | |
| Q62181 | (Get FASTA) |
Promoters| RGD ID: | 6838307 | ||||||||||
| Promoter ID: | MM_KWN:41449 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day1, BoneMarrow_2Hour, BoneMarrow_4Hour, Lung | ||||||||||
| Transcripts: | ENSMUST00000030568 | ||||||||||
| Position: |
|
| RGD ID: | 6878150 | ||||||||||
| Promoter ID: | EPDNEW_M2526 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Sema3c_1 | ||||||||||
| Description: | sema domain, immunoglobulin domain , short basic domain, secreted,3C | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000028780 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000030568 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000030568 | ENTREZGENE |
| Entrez Gene | 20348 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| WD40/YVTN_repeat-like | UniProtKB/Swiss-Prot | |
| Germonline | ENSMUSG00000028780 | |
| HomoloGene Group ID | 36201 | ENTREZGENE |
| InterPro | Ig-like | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_I-set | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Plexin-like | UniProtKB/Swiss-Prot | |
| Plexin-like_fold | UniProtKB/Swiss-Prot | |
| Semaphorin | UniProtKB/Swiss-Prot | |
| Semaphorin/CD100_Ag | UniProtKB/Swiss-Prot | |
| WD40/YVTN_repeat-like_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00311104 | UniProtKB/Swiss-Prot |
| IPI00988246 | UniProtKB/TrEMBL | |
| IPI00988580 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:20348 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:107557 | ENTREZGENE |
| PANTHER | PTHR11036 | UniProtKB/Swiss-Prot |
| Pfam | I-set | UniProtKB/Swiss-Prot |
| Sema | UniProtKB/Swiss-Prot | |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot |
| SEMA | UniProtKB/Swiss-Prot | |
| SMART | PSI | UniProtKB/Swiss-Prot |
| Sema | UniProtKB/Swiss-Prot | |
| SM00409 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Plexin-like_fold | UniProtKB/Swiss-Prot |
| Sema | UniProtKB/Swiss-Prot | |
| UniGene | Mm.5071 | ENTREZGENE |
| UniProt | E9PXL2_MOUSE | UniProtKB/TrEMBL |
| E9Q0Z0_MOUSE | UniProtKB/TrEMBL | |
| SEM3C_MOUSE | UniProtKB/Swiss-Prot |
| More on Sema3c | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
MGI Report |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1319639 |
| Created: | 2005-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




