Gene: Nthl1 (nth (endonuclease III)-like 1 (E.coli))
Mus musculus
Symbol:
Nthl1
Name:
nth (endonuclease III)-like 1 (E.coli)
Description:
ENCODES a protein that exhibits DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding (ortholog); INVOLVED IN nucleotide-excision repair, DNA incision, 5'-to lesion; base-excision repair, AP site formation (ortholog); PARTICIPATES IN base excision repair pathway; ASSOCIATED WITH abnormal DNA repair; other aberrant phenotype; FOUND IN mitochondrion; nucleus; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
endonuclease III-like protein 1; Nth1; Octs3; thymine glycol DNA glycosylase/AP lyase
Orthologs:
Homo sapiens : NTHL1
(nth endonuclease III-like 1 (E. coli))
HGNC
Rattus norvegicus : Nthl1
(nth (endonuclease III)-like 1 (E.coli))
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 17 24,632,682 - 24,638,838 + NCBI Mouse cM Map 17 + NCBI Mouse Celera Assembly 17 25,155,083 - 25,161,227 + NCBI Mouse Genome Assembly Build 37 17 24,769,627 - 24,775,783 + NCBI Mouse Genome Assembly Build 36.1 17 24,769,655 - 24,775,782 + NCBI Mouse Cytogenetic Map 17 A3 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of NTHL1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNA CTD PMID:17942748 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of NTHL1 mRNA CTD PMID:16684588 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1319554 6480464 Tetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NTHL1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1309289 6480464 Tetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNA CTD PMID:17942748 2,6-dinitrotoluene affects expression ISO RGD:1309289 6480464 2,6-dinitrotoluene affects the expression of NTHL1 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1319554 6480464 beta-methylcholine affects the expression of NTHL1 mRNA CTD PMID:21179406 actinomycin D decreases expression ISO RGD:1319554 6480464 Dactinomycin results in decreased expression of NTHL1 mRNA CTD PMID:21527772 aflatoxin B1 decreases expression ISO RGD:1319554 6480464 Aflatoxin B1 results in decreased expression of NTHL1 mRNA CTD PMID:22100608 all-trans-retinoic acid decreases expression ISO RGD:1319554 6480464 Tretinoin results in decreased expression of NTHL1 mRNA CTD PMID:16140955 aniline increases expression ISO RGD:1309289 6480464 aniline results in increased expression of NTHL1 mRNA CTD PMID:23352893 aniline multiple interactions ISO RGD:1309289 6480464 aniline results in increased expression of and results in increased activity of NTHL1 protein CTD PMID:23352893 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of NTHL1 mRNA CTD PMID:22228805 bezafibrate increases expression EXP 6480464 Bezafibrate results in increased expression of NTHL1 mRNA CTD PMID:15447978 cadmium dichloride multiple interactions ISO RGD:1319554 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA CTD PMID:12634122 cadmium dichloride decreases methylation ISO RGD:1309289 6480464 Cadmium Chloride results in decreased methylation of NTHL1 promoter CTD PMID:22457795 cisplatin multiple interactions ISO RGD:1319554 6480464 Folic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA] CTD PMID:16898872 cobalt dichloride decreases expression ISO RGD:1319554 6480464 cobaltous chloride results in decreased expression of NTHL1 mRNA CTD PMID:19376846 PMID:19320972 cobalt dichloride decreases expression ISO RGD:1319554 6480464 cobaltous chloride results in decreased expression of NTHL1 mRNA CTD PMID:19320972 PMID:19376846 copper atom multiple interactions ISO RGD:1319554 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NTHL1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1319554 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NTHL1 mRNA CTD PMID:20971185 copper(2+) sulfate decreases expression ISO RGD:1319554 6480464 Copper Sulfate results in decreased expression of NTHL1 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1319554 6480464 Cyclosporine results in decreased expression of NTHL1 mRNA CTD PMID:20106945 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of NTHL1 mRNA CTD PMID:21266533 dichromium trioxide multiple interactions ISO RGD:1319554 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA CTD PMID:12634122 flutamide increases expression EXP 6480464 Flutamide results in increased expression of NTHL1 mRNA CTD PMID:19442681 folic acid multiple interactions ISO RGD:1319554 6480464 Folic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA] CTD PMID:16898872 lead diacetate multiple interactions ISO RGD:1319554 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA CTD PMID:12634122 methyl methanesulfonate decreases expression ISO RGD:1319554 6480464 Methyl Methanesulfonate results in decreased expression of NTHL1 mRNA CTD PMID:21527772 miconazole increases expression ISO RGD:1309289 6480464 Miconazole results in increased expression of NTHL1 mRNA CTD PMID:22262564 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NTHL1 mRNA] CTD PMID:16137721 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of NTHL1 mRNA CTD PMID:17562736 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTHL1 mRNA CTD PMID:19710929 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of NTHL1 mRNA CTD PMID:22155349
Gene Ontology Annotations
Biological Process
base-excision repair IEA InterPro:IPR003265 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 base-excision repair, AP site formation ISO UniProtKB:P78549 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 DNA repair TAS 2290270 MGI:MGI:2389521|PMID:12200441 MGI MGI:MGI:2389521 PMID:12200441 metabolic process IEA UniProtKB-KW:KW-0326 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleotide-excision repair, DNA incision, 5'-to lesion ISO UniProtKB:P78549 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleotide-excision repair, DNA incision, 5'-to lesion IDA 2290270 MGI:MGI:1289919|PMID:9743625 UniProtKB MGI:MGI:1289919 PMID:9743625 response to DNA damage stimulus IEA UniProtKB-KW:KW-0227 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
1301279 Obq4_m obesity QTL 4 (mouse) Not determined 17 1 25636109 Mouse 1357902 Obq19_m obesity QTL 19 (mouse) Not determined 17 1 25636109 Mouse 1301615 Cfld3_m cystic fibrosis lung disease 3 (mouse) Not determined 17 1 27055575 Mouse 1300613 Pcyts4_m plasmacytoma susceptibility 4 (mouse) Not determined 17 1 27055575 Mouse 4141973 Adip18_m adiposity 18 (mouse) Not determined 17 1 27489635 Mouse 1302100 Circp2_m circadian photosensitivity 2 (mouse) Not determined 17 1 29172432 Mouse 4141308 Secia8_m small effect CIA locus 8 (mouse) Not determined 17 3264877 37265001 Mouse 1300890 Bhr3_m bronchial hyperresponsiveness 3 (mouse) Not determined 17 3924615 48698388 Mouse 1300706 Alan1_m alloantigen response 1 (mouse) Not determined 17 4804477 46295725 Mouse 4141608 Phl1_m progressive hearing loss 1 (mouse) Not determined 17 7849876 29405394 Mouse 1357816 Fmgty14_m femur geometry 14 (mouse) Not determined 17 8502885 42503120 Mouse 1301935 Skull24_m skull morphology 24 (mouse) Not determined 17 8502885 42503120 Mouse 4142029 Vmmt14_m vertebral morphology and mechanical traits 14 (mouse) Not determined 17 8502885 42503120 Mouse 4141959 Chlq8_m circulating hormone level QTL 8 (mouse) Not determined 17 8502885 42503120 Mouse 1357588 Manln18_m mandible length 18 (mouse) Not determined 17 8502885 42503120 Mouse 1300787 Cd8mts5_m CD8 memory T cell subset 5 (mouse) Not determined 17 8502885 42503120 Mouse 1558788 Ptnu2_m proteinuria 2 (mouse) Not determined 17 8502885 42503120 Mouse 1302028 Asbb3_m autoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse) Not determined 17 10796090 44796190 Mouse 1357504 Mhstq1_m male hybrid sterility QTL 1 (mouse) Not determined 17 10796090 44796190 Mouse 1558807 Ceat1_m chronic experimental autoimmune thyroiditis 1 (mouse) Not determined 17 12610661 26319104 Mouse 1558766 Mmtp2_m modifier of mammary tumor progression 2 (mouse) Not determined 17 14041343 48041467 Mouse 1558886 Lgth9_m body length 9 (mouse) Not determined 17 14979623 48979731 Mouse 1300914 Pcir4_m periosteal circumference 4 (mouse) Not determined 17 14979623 48979731 Mouse 1302070 Tbbmd7_m total body bone mineral density 7 (mouse) Not determined 17 14979623 48979731 Mouse 1300995 Fembrs4_m femur breaking strength 4 (mouse) Not determined 17 14979623 48979731 Mouse 1302152 Skull25_m skull morphology 25 (mouse) Not determined 17 16737692 50737814 Mouse 4141038 Acla1_m anticardiolipin antibody 1 (mouse) Not determined 17 16737692 50737814 Mouse 1301005 Idd16_m insulin dependent diabetes susceptibility 16 (mouse) Not determined 17 16737692 50737814 Mouse 1301505 Tir1_m trypanosome infection response 1 (mouse) Not determined 17 16737692 50737814 Mouse 4141228 Pbat1_m platelet-binding antibody-associated thrombocytopenia 1 (mouse) Not determined 17 16737692 50737814 Mouse 1301056 Pas2_m pulmonary adenoma susceptibility 2 (mouse) Not determined 17 16737692 50737814 Mouse 1302140 Wta4_m weight adult 4 (mouse) Not determined 17 16737692 50737814 Mouse 1558734 Arfix_m antibody response to human factor IX (mouse) Not determined 17 16874679 50874850 Mouse 1357765 Cmcs_m cerebral malaria susceptibility in CBA/N (mouse) Not determined 17 17137861 51137980 Mouse 1302189 Dps3_m delta power in slow-wave sleep 3 (mouse) Not determined 17 17137861 51137980 Mouse 1300535 Char3_m P. chabaudi malaria resistance QTL 3 (mouse) Not determined 17 17380179 51380316 Mouse 1302042 Acsns3_m Angiostrongylus costaricensis nematode susceptibility 3 (mouse) Not determined 17 17380179 51380316 Mouse 1357574 Hcif1_m hepatocarcinogenesis in females 1 (mouse) Not determined 17 17380179 51380316 Mouse 4141496 Krcn1_m keratoconus 1 (mouse) Not determined 17 17880993 51881142 Mouse 1301759 Sles1_m systemic lupus erythmatosus suppressor 1 (mouse) Not determined 17 17880998 51881144 Mouse 1302038 Radpf1_m radiation pulmonary fibrosis 1 (mouse) Not determined 17 18216590 52216736 Mouse 1301097 Bplpf1_m bleomycin pulmonary fibrosis 1 (mouse) Not determined 17 18216590 52216736 Mouse 1302091 Pidys_m particle-induced immune disfunction (mouse) Not determined 17 19635102 53635244 Mouse 1302069 Bbaa8_m B.burgdorferi-associated arthritis 8 (mouse) Not determined 17 20346853 54346954 Mouse 1301454 Eae5_m susceptibility to experimental allergic encephalomyelitis 5 (mouse) Not determined 17 24438808 58438922 Mouse