Neu4 (sialidase 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Neu4 (sialidase 4) Mus musculus
Analyze
Symbol: Neu4
Name: sialidase 4
RGD ID: 1318507
MGI Page MGI
Description: Enables exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. Involved in ganglioside catabolic process; glycoprotein catabolic process; and negative regulation of neuron projection development. Located in neuron projection and plasma membrane. Is expressed in brain; liver; lung; metanephros; and spleen. Orthologous to human NEU4 (neuraminidase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9330166I04; N-acetyl-alpha-neuraminidase 4; neuraminidase 4; sialidase-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,948,215 - 93,956,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,948,173 - 93,956,056 (+)EnsemblGRCm39 Ensembl
GRCm38194,020,493 - 94,028,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,020,451 - 94,028,334 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,917,070 - 95,924,911 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,850,899 - 95,858,740 (+)NCBIMGSCv36mm8
Celera196,885,435 - 96,893,274 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14637003   PMID:14681479   PMID:16141072   PMID:16141073   PMID:17883393   PMID:18270209   PMID:18614015  
PMID:19506080   PMID:20862357   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22393058   PMID:28442549   PMID:30359429   PMID:34686927   PMID:35363389  


Genomics

Comparative Map Data
Neu4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,948,215 - 93,956,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,948,173 - 93,956,056 (+)EnsemblGRCm39 Ensembl
GRCm38194,020,493 - 94,028,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,020,451 - 94,028,334 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,917,070 - 95,924,911 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,850,899 - 95,858,740 (+)NCBIMGSCv36mm8
Celera196,885,435 - 96,893,274 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.46NCBI
NEU4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,809,193 - 241,817,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,809,065 - 241,817,413 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,750,288 - 242,758,739 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,400,746 - 242,407,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 342242,472,062 - 242,478,724NCBI
Celera2236,415,462 - 236,423,972 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,501,226 - 234,509,785 (+)NCBIHuRef
CHM1_12242,756,215 - 242,764,748 (+)NCBICHM1_1
T2T-CHM13v2.02242,310,986 - 242,319,206 (+)NCBIT2T-CHM13v2.0
Neu4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,844,261 - 101,849,917 (+)NCBIGRCr8
mRatBN7.2994,396,920 - 94,402,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,396,920 - 94,402,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,832,389 - 102,838,045 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,967,672 - 107,973,326 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,323,784 - 106,329,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09101,284,902 - 101,290,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,284,902 - 101,290,558 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,005,082 - 101,008,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,655,816 - 100,661,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,150,680 - 93,156,336 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,343,347 - 93,360,169 (+)NCBI
Celera991,931,048 - 91,936,704 (+)NCBICelera
Cytogenetic Map9q36NCBI
Neu4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554266,174 - 71,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495554266,214 - 70,456 (-)NCBIChiLan1.0ChiLan1.0
NEU4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,517,325 - 144,526,774 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,532,652 - 144,541,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012130,824,179 - 130,833,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NEU4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,594,865 - 51,602,500 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,815,995 - 51,824,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,795,643 - 51,804,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,782,762 - 51,803,768 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,645,546 - 51,654,141 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,384,795 - 51,393,349 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,661,976 - 51,670,484 (+)NCBIUU_Cfam_GSD_1.0
Neu4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303193,042,611 - 193,054,249 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936745172,983 - 175,470 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEU4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,325,135 - 140,328,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,324,087 - 140,332,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEU4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,845,536 - 127,852,873 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,847,391 - 127,852,519 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,467,646 - 71,474,913 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Neu4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,716,659 - 5,720,542 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,716,165 - 5,720,542 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Neu4
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:862
Count of miRNA genes:529
Interacting mature miRNAs:637
Transcripts:ENSMUST00000050890
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193536855120529678Mouse

Markers in Region
Neu4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1DUniSTS
cM Map1 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000050890   ⟹   ENSMUSP00000051151
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,948,215 - 93,956,056 (+)Ensembl
GRCm38.p6 Ensembl194,020,493 - 94,028,334 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190212   ⟹   ENSMUSP00000140127
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,948,173 - 93,953,138 (+)Ensembl
GRCm38.p6 Ensembl194,020,451 - 94,025,416 (+)Ensembl
RefSeq Acc Id: NM_001310769   ⟹   NP_001297698
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,948,215 - 93,956,056 (+)NCBI
GRCm38194,020,493 - 94,028,334 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173772   ⟹   NP_776133
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,948,215 - 93,956,056 (+)NCBI
GRCm38194,020,493 - 94,028,334 (+)NCBI
MGSCv37195,917,070 - 95,924,911 (+)RGD
Celera196,885,435 - 96,893,274 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_776133   ⟸   NM_173772
- Peptide Label: isoform 2
- UniProtKB: Q6NS66 (UniProtKB/Swiss-Prot),   Q8BZL1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001297698   ⟸   NM_001310769
- Peptide Label: isoform 1
- UniProtKB: C5NTX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000051151   ⟸   ENSMUST00000050890
RefSeq Acc Id: ENSMUSP00000140127   ⟸   ENSMUST00000190212
Protein Domains
Sialidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BZL1-F1-model_v2 AlphaFold Q8BZL1 1-478 view protein structure

Promoters
RGD ID:6874586
Promoter ID:EPDNEW_M744
Type:initiation region
Name:Neu4_1
Description:Mus musculus sialidase 4 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,020,463 - 94,020,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2661364 AgrOrtholog
Ensembl Genes ENSMUSG00000034000 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000050890 ENTREZGENE
  ENSMUST00000050890.8 UniProtKB/Swiss-Prot
  ENSMUST00000190212 ENTREZGENE
  ENSMUST00000190212.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Sialidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialidase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:241159 UniProtKB/Swiss-Prot
MGD MGI:2661364 ENTREZGENE
NCBI Gene 241159 ENTREZGENE
PANTHER PTHR10628 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10628:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BNR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Neu4 PhenoGen
Superfamily-SCOP SSF50939 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C5NTX9 ENTREZGENE, UniProtKB/TrEMBL
  NEUR4_MOUSE UniProtKB/Swiss-Prot
  Q6NS66 ENTREZGENE
  Q8BZL1 ENTREZGENE
UniProt Secondary Q6NS66 UniProtKB/Swiss-Prot