USP5 (ubiquitin specific peptidase 5 (isopeptidase T))

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Keyword

Gene: USP5 (ubiquitin specific peptidase 5 (isopeptidase T)) Homo sapiens

Symbol:

USP5

Name:

ubiquitin specific peptidase 5 (isopeptidase T)

Description:

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

deubiquitinating enzyme 5; isopeptidase T; ISOT; OTTHUMP00000240481; OTTHUMP00000240482; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific protease 5 (isopeptidase t); ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5

Orthologs:

Mus musculus : Usp5 (ubiquitin specific peptidase 5 (isopeptidase T)) MGI
Rattus norvegicus : Usp5 (ubiquitin specific peptidase 5 (isopeptidase T))

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	12	6,892,718 - 6,907,229	+	NCBI
Human Genome Assembly HuRef	12	6,815,013 - 6,829,524	+	NCBI
Human Genome Assembly GRCh37	12	6,961,285 - 6,975,796	+	NCBI
Human Genome Assembly Build 36	12	6,831,546 - 6,846,057	+	NCBI
Human Cytogenetic Map	12	p13		NCBI
Human Genome Assembly	12	6,831,583 - 6,846,054		NCBI