PBX1 (pre-B-cell leukemia homeobox 1)

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Keyword

Gene: PBX1 (pre-B-cell leukemia homeobox 1) Homo sapiens

Symbol:

PBX1

Name:

pre-B-cell leukemia homeobox 1

Description:

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

DKFZp686B09108; homeobox protein PBX1; homeobox protein PRL; MGC126627; OTTHUMP00000032205; OTTHUMP00000032206; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia transcription factor 1

Orthologs:

Mus musculus : Pbx1 (pre B cell leukemia homeobox 1) MGI
Rattus norvegicus : Pbx1 (pre-B-cell leukemia homeobox 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	1	171,078,704 - 171,371,133	+	NCBI
Human Genome Assembly HuRef	1	135,774,690 - 136,068,016	+	NCBI
Human Genome Assembly GRCh37	1	164,528,597 - 164,821,067	+	NCBI
Human Genome Assembly Build 36	1	162,795,561 - 163,082,934	+	NCBI
Human Cytogenetic Map	1	q23		NCBI
Human Genome Assembly	1	161,260,594 - 161,547,967		NCBI