LPIN1 (lipin 1) - Rat Genome Database

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Keyword

Gene: LPIN1 (lipin 1) Homo sapiens

Symbol:

LPIN1

Name:

lipin 1

Description:

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

DKFZp781P1796; KIAA0188; lipin-1; OTTHUMP00000147624; OTTHUMP00000179151; OTTHUMP00000179153; PAP1; phosphatidate phosphatase LPIN1

Orthologs:

Mus musculus : Lpin1 (lipin 1) MGI
Rattus norvegicus : Lpin1 (lipin 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	11,788,925 - 11,938,851	+	NCBI
Human Genome Assembly HuRef	2	11,669,235 - 11,818,856	+	NCBI
Human Genome Assembly GRCh37	2	11,817,705 - 11,967,535	+	NCBI
Human Genome Assembly Build 36	2	11,804,191 - 11,884,986	+	NCBI
Human Cytogenetic Map	2	p25.1		NCBI
Human Genome Assembly	2	11,837,337 - 11,918,129		NCBI