Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SPATA13 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of SPATA13 mRNA more ... | CTD | PMID:17962382 and PMID:30165855 | 17beta-estradiol | affects expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Estradiol affects the expression of SPATA13 mRNA | CTD | PMID:32145629 | 17beta-estradiol | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SPATA13 mRNA | CTD | PMID:17962382 more ... | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of SPATA13 mRNA | CTD | PMID:29581250 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPATA13 mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SPATA13 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of SPATA13 intron] which results in increased expression of SPATA13 mRNA | CTD | PMID:33017471 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPATA13 mRNA | CTD | PMID:26290441 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SPATA13 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SPATA13 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of SPATA13 mRNA | CTD | PMID:28973697 | acrylamide | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of SPATA13 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of SPATA13 mRNA | CTD | PMID:19770486 | aflatoxin B1 | affects methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of SPATA13 intron | CTD | PMID:30157460 | aflatoxin B1 | increases methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SPATA13 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | affects methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | aflatoxin B2 affects the methylation of SPATA13 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SPATA13 mRNA | CTD | PMID:21934132 | amphetamine | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of SPATA13 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SPATA13 mRNA | CTD | PMID:33212167 | arsenous acid | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SPATA13 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | affects methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SPATA13 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[e]pyrene | decreases methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of SPATA13 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SPATA13 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SPATA13 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SPATA13 mRNA | CTD | PMID:35598803 | bisphenol A | decreases methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SPATA13 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SPATA13 gene | CTD | PMID:31601247 | bisphenol A | affects expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of SPATA13 mRNA | CTD | PMID:32145629 | bisphenol A | increases methylation | ISO | Spata13 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of SPATA13 gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SPATA13 mRNA | CTD | PMID:30816183 | cadmium dichloride | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of SPATA13 mRNA | CTD | PMID:33453195 | chlordecone | increases expression | EXP | | 6480464 | Chlordecone results in increased expression of SPATA13 mRNA | CTD | PMID:29980752 | ciguatoxin CTX1B | affects expression | EXP | | 6480464 | Ciguatoxins affects the expression of SPATA13 mRNA | CTD | PMID:18353800 | cisplatin | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SPATA13 mRNA | CTD | PMID:27594783 | cisplatin | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of SPATA13 mRNA | CTD | PMID:27392435 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of SPATA13 mRNA | CTD | PMID:23811191 | copper(II) sulfate | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SPATA13 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SPATA13 mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SPATA13 mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SPATA13 mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of SPATA13 mRNA | CTD | PMID:21266533 | dicrotophos | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SPATA13 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATA13 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SPATA13 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of SPATA13 mRNA | CTD | PMID:29391264 | ethanol | multiple interactions | EXP | | 6480464 | Ethanol affects the expression of and affects the splicing of SPATA13 mRNA | CTD | PMID:30319688 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of SPATA13 mRNA | CTD | PMID:30319688 | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of SPATA13 mRNA | CTD | PMID:34813904 | fenvalerate | increases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of SPATA13 mRNA | CTD | PMID:30307764 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of SPATA13 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SPATA13 mRNA | CTD | PMID:27664576 | FR900359 | decreases phosphorylation | ISO | SPATA13 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SPATA13 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SPATA13 gene | CTD | PMID:31601247 | furan | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | furan results in decreased expression of SPATA13 mRNA | CTD | PMID:25539665 and PMID:27387713 | gentamycin | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of SPATA13 mRNA | CTD | PMID:33387578 | hydrogen cyanide | decreases expression | EXP | | 6480464 | Hydrogen Cyanide results in decreased expression of SPATA13 mRNA | CTD | PMID:33914522 | hydroquinone O-beta-D-glucopyranoside | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Arbutin results in increased expression of SPATA13 mRNA | CTD | PMID:17103032 | indometacin | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SPATA13 mRNA | CTD | PMID:28628672 | lipopolysaccharide | increases expression | EXP | | 6480464 | Lipopolysaccharides results in increased expression of SPATA13 mRNA | CTD | PMID:25890327 | methapyrilene | decreases methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of SPATA13 intron | CTD | PMID:30157460 | methidathion | decreases expression | EXP | | 6480464 | methidathion results in decreased expression of SPATA13 mRNA | CTD | PMID:34813904 | methoxychlor | affects methylation | ISO | Spata13 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of SPATA13 gene | CTD | PMID:35440735 | paracetamol | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of SPATA13 mRNA | CTD | PMID:33387578 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of SPATA13 mRNA | CTD | PMID:36331819 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of SPATA13 mRNA | CTD | PMID:23811191 | potassium cyanide | decreases expression | EXP | | 6480464 | Potassium Cyanide results in decreased expression of SPATA13 mRNA | CTD | PMID:33914522 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of SPATA13 mRNA | CTD | PMID:21278054 | raloxifene | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Raloxifene Hydrochloride results in increased expression of SPATA13 mRNA | CTD | PMID:17962382 | SB 431542 | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATA13 mRNA | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SPATA13 mRNA | CTD | PMID:25895662 | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide results in decreased expression of SPATA13 mRNA | CTD | PMID:19073995 | sodium arsenite | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SPATA13 mRNA | CTD | PMID:29301061 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SPATA13 mRNA | CTD | PMID:21641980 | sunitinib | decreases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SPATA13 mRNA | CTD | PMID:31533062 | tamoxifen | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Tamoxifen results in increased expression of SPATA13 mRNA | CTD | PMID:17962382 | tetrachloromethane | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of SPATA13 mRNA | CTD | PMID:31150632 | trichostatin A | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SPATA13 mRNA | CTD | PMID:24935251 | triclosan | increases methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | Triclosan results in increased methylation of SPATA13 gene | CTD | PMID:34523531 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of SPATA13 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of SPATA13 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of SPATA13 mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | SPATA13 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SPATA13 gene | CTD | PMID:29154799 | valproic acid | multiple interactions | ISO | SPATA13 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATA13 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | SPATA13 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SPATA13 mRNA | CTD | PMID:23179753 more ... | vinclozolin | decreases expression | ISO | Spata13 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of SPATA13 mRNA | CTD | PMID:23034163 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. | Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48. |
| 4. | Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. | Powles N, etal., Dev Biol 2004 Apr 1;268(1):24-38. |
| 5. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 7. | Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. | Tchernev VT, etal., Genomics 1997 Feb 15;40(1):170-4. |
| 8. | Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. | Yoshizawa M, etal., Gene Expr Patterns 2003 Jun;3(3):375-81. |
Additional References at PubMed
| PMID:7490078 | PMID:8889548 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:14610273 | PMID:16141072 | PMID:16141073 |
| PMID:16602821 | PMID:17967808 | PMID:18799693 | PMID:19893577 | PMID:19906978 | PMID:20436479 | PMID:21267068 | PMID:21491433 | PMID:21873635 | PMID:24154525 | PMID:27881777 | PMID:28671696 |
| PMID:31020388 | PMID:32541003 | PMID:34321999 |
Genomics
Comparative Map Data
| Spata13 (Mus musculus - house mouse) |
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| SPATA13 (Homo sapiens - human) |
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| Spata13 (Rattus norvegicus - Norway rat) |
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| Spata13 (Chinchilla lanigera - long-tailed chinchilla) |
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| SPATA13 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SPATA13 (Canis lupus familiaris - dog) |
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| Spata13 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SPATA13 (Sus scrofa - pig) |
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| SPATA13 (Chlorocebus sabaeus - green monkey) |
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| Spata13 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Spata13
9039 total Variants 
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