Gene: NDUFS2 (NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase))  Homo sapiens
Symbol: NDUFS2
Name: NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Description: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CI-49; CI-49kD; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 49kDa subunit; complex I-49kD; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase NDUFS2 subunit; OTTHUMP00000032241
Orthologs: Mus musculus : Ndufs2 (NADH dehydrogenase (ubiquinone) Fe-S protein 2)  MGI
Rattus norvegicus : Ndufs2 (NADH dehydrogenase (ubiquinone) Fe-S protein 2)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11167,665,359 - 167,680,454+NCBI
Human Genome Assembly HuRef1132,526,050 - 132,541,132+NCBI
Human Genome Assembly GRCh371161,169,105 - 161,184,185+NCBI
Human Genome Assembly Build 361159,435,729 - 159,450,809+NCBI
Human Cytogenetic Map1q23 NCBI
Human Genome Assembly1157,982,177 - 157,997,255 NCBI
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Nomenclature History
  
More on NDUFS2
Entrez Gene
Ensembl Gene
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Vista
Vista + UCSC

RGD Object Information
RGD ID: 1316107
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2013-03-06
Status: ACTIVE



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