TRAF4 (TNF receptor-associated factor 4)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene: TRAF4 (TNF receptor-associated factor 4) Homo sapiens

Symbol:

TRAF4

Name:

TNF receptor-associated factor 4

Description:

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CART1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; OTTHUMP00000163519; RING finger protein 83; RNF83; TNF receptor-associated factor 4; tumor necrosis receptor-associated factor 4A

Orthologs:

Mus musculus : Traf4 (TNF receptor associated factor 4) MGI
Rattus norvegicus : Traf4 (Tnf receptor associated factor 4)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	17	27,131,073 - 27,138,093	+	NCBI
Human Genome Assembly HuRef	17	23,279,873 - 23,286,815	+	NCBI
Human Genome Assembly GRCh37	17	27,071,023 - 27,077,976	+	NCBI
Human Genome Assembly Build 36	17	24,095,150 - 24,102,103	+	NCBI
Human Cytogenetic Map	17	q11-q12		NCBI
Human Genome Assembly	17	24,095,172 - 24,101,223		NCBI