FBXO18 (F-box protein, helicase, 18)

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Keyword

Gene: FBXO18 (F-box protein, helicase, 18) Homo sapiens

Symbol:

FBXO18

Name:

F-box protein, helicase, 18

Description:

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

F-box DNA helicase 1; F-box only protein 18; F-box only protein, helicase, 18; FBH1; Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937; OTTHUMP00000019016; OTTHUMP00000019017

Orthologs:

Mus musculus : Fbxo18 (F-box protein 18) MGI
Rattus norvegicus : Fbxo18 (F-box protein, helicase, 18)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	10	5,845,850 - 5,893,758	+	NCBI
Human Genome Assembly HuRef	10	5,858,336 - 5,906,371	+	NCBI
Human Genome Assembly GRCh37	10	5,931,535 - 5,979,558	+	NCBI
Human Celera Assembly	10	5,862,606 - 5,909,945	+	NCBI
Human Genome Assembly Build 36	10	5,972,220 - 6,019,562	+	NCBI
Human Cytogenetic Map	10	p15.1		NCBI