Gene: ZBTB7B (zinc finger and BTB domain containing 7B)
Homo sapiens
Symbol:
ZBTB7B
Name:
zinc finger and BTB domain containing 7B
Description:
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
c-Krox; c-KROX; DKFZp686G01254; hcKrox; hcKROX; krueppel-related zinc finger protein cKrox; kruppel-related zinc finger protein hcKrox; OTTHUMP00000035544; OTTHUMP00000035545; T-helper-inducing POZ/Krueppel-like factor; THPOK; ZBTB15; zfp-67; ZFP-67; ZFP67; zinc finger and BTB domain containing 15; zinc finger and BTB domain-containing protein 15; zinc finger and BTB domain-containing protein 7B; zinc finger protein 67 homolog; zinc finger protein 67 homolog (mouse); zinc finger protein 857B; zinc finger protein Th-POK; ZNF857B
Orthologs:
Mus musculus : Zbtb7b
(zinc finger and BTB domain containing 7B)
MGI
Zbtb7b
(zinc finger and BTB domain containing 7B)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 161,477,621 - 161,493,424 + NCBI Human Genome Assembly HuRef 1 126,337,222 - 126,352,993 + NCBI Human Genome Assembly GRCh37 1 154,975,106 - 154,991,001 + NCBI Human Genome Assembly Build 36 1 153,241,736 - 153,257,623 + NCBI Human Cytogenetic Map 1 q21.3 NCBI Human Genome Assembly 1 151,799,996 - 151,802,525 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1557107 6480464 Ethinyl Estradiol results in increased expression of ZBTB7B mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1557107 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZBTB7B mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1557107 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZBTB7B mRNA CTD PMID:17942748 2,6-dinitrotoluene affects expression ISO RGD:1305963 6480464 2,6-dinitrotoluene affects the expression of ZBTB7B mRNA CTD PMID:21346803 4,4'-diaminodiphenylmethane increases expression ISO RGD:1557107 6480464 4,4'-diaminodiphenylmethane results in increased expression of ZBTB7B mRNA CTD PMID:18648102 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid decreases expression EXP 6480464 Am 580 results in decreased expression of ZBTB7B mRNA CTD PMID:16982809 all-trans-retinoic acid decreases expression ISO RGD:1557107 6480464 Tretinoin results in decreased expression of ZBTB7B mRNA CTD PMID:16604517 benzo[a]pyrene multiple interactions ISO RGD:1557107 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ZBTB7B mRNA CTD PMID:21715664 glutathione decreases expression ISO RGD:1305963 6480464 Glutathione deficiency results in decreased expression of ZBTB7B mRNA CTD PMID:20621112 hydroquinone O-beta-D-glucopyranoside decreases expression EXP 6480464 Arbutin results in decreased expression of ZBTB7B mRNA CTD PMID:17103032 paracetamol affects expression ISO RGD:1557107 6480464 Acetaminophen affects the expression of ZBTB7B mRNA CTD PMID:17562736 rosiglitazone decreases expression EXP 6480464 rosiglitazone results in decreased expression of ZBTB7B mRNA CTD PMID:16982809 testosterone increases expression ISO RGD:1557107 6480464 Testosterone results in increased expression of ZBTB7B mRNA CTD PMID:20403060 valproic acid affects expression ISO RGD:1557107 6480464 Valproic Acid affects the expression of ZBTB7B mRNA CTD PMID:17963808
Gene Ontology Annotations
Biological Process cell differentiation IEA UniProtKB-KW:KW-0221 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 ectoderm development TAS 2290271 PMID:7937772 PINC PMID:7937772 multicellular organismal development IEA UniProtKB-KW:KW-0217 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 regulation of transcription, DNA-dependent IEA UniProtKB-KW:KW-0805 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 transcription from RNA polymerase II promoter TAS 2290271 PMID:7937772 PINC PMID:7937772
1581540 BP60_H Blood pressure QTL 60 (human) Blood pressure hypertension susceptibility 1 19957148 198620398 Human 1331645 COPD18_H Chronic obstructive pulmonary disease QTL 18 (human) 1.92 Chronic airflow obstruction FEV1/FVC ratio 1 74229391 157932881 Human 1357381 BW57_H Body weight QTL 57 (human) 1 .0001 Body weight fat free mass after exercise training 1 91558770 166956374 Human 2289241 SLIPL21_H Serum lipid level QTL 21 (human) 3.39 .014402 Lipid level lipoprotein level 1 119678264 162362069 Human 2316338 GLUCO223_H Glucose level QTL 223 (human) 3.09 .00008 Glucose level 1 139437503 165437503 Human 2293485 PRSTS288_H Prostate tumor susceptibility QTL 288 (human) .031 Prostate tumor susceptibility 1 144932827 170932827 Human 2316705 GLUCO265_H Glucose level QTL 265 (human) 2.5 .00066 Glucose level 1 147767637 173767637 Human 2314801 GLUCO120_H Glucose level QTL 120 (human) Glucose level non-insulin dependent 1 148192596 174192596 Human 1298491 BP5_H Blood pressure QTL 5 (human) 2.96 Blood pressure diastolic 1 149361992 175361992 Human 1643514 BW260_H Body weight QTL 260 (human) 1.6 .00328 Body weight body mass index 1 149361992 175361992 Human 2301804 PRSTS430_H Prostate tumor susceptibility QTL 430 (human) 2.93 .0002 Prostate tumor susceptibility 1 150559802 176559802 Human 2289201 BW345_H Body weight QTL 345 (human) .0148 Body fat amount percent fat 1 150559802 176559802 Human 2293474 PRSTS289_H Prostate tumor susceptibility QTL 289 (human) .003 Prostate tumor susceptibility 1 150559802 176559802 Human 1643072 BW150_H Body weight QTL 150 (human) .0297 Body fat amount percent body fat 1 152437380 178437380 Human 2314796 GLUCO121_H Glucose level QTL 121 (human) Glucose level non-insulin dependent 1 153596141 179596141 Human
Gene Ontology Annotations
