Gene: ELF5 (E74-like factor 5 (ets domain transcription factor))
Homo sapiens
Symbol:
ELF5
Name:
E74-like factor 5 (ets domain transcription factor)
Description:
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE2; ETS-related transcription factor Elf-5; OTTHUMP00000232932; OTTHUMP00000232933; OTTHUMP00000232934
Orthologs:
Mus musculus : Elf5
(E74-like factor 5)
MGI
Elf5
(E74-like factor 5)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 34,429,004 - 34,464,008 - NCBI Human Genome Assembly HuRef 11 34,197,704 - 34,232,735 - NCBI Human Genome Assembly GRCh37 11 34,500,342 - 34,535,347 - NCBI Human Genome Assembly Build 36 11 34,456,918 - 34,491,906 - NCBI Human Cytogenetic Map 11 p13-p12 NCBI Human Genome Assembly 11 34,456,917 - 34,489,922 NCBI
Model
Gene-Chemical Interaction Annotations
17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ELF5 mRNA CTD PMID:19619570 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of ELF5 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ELF5 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1314144 6480464 Tetrachlorodibenzodioxin results in increased expression of ELF5 mRNA CTD PMID:17035482 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ELF5 mRNA CTD PMID:19619570 ciglitazone multiple interactions EXP 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of ELF5 mRNA; more ... CTD PMID:16197558 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ELF5 mRNA CTD PMID:19167446 diethylstilbestrol increases expression ISO RGD:1314144 6480464 Diethylstilbestrol results in increased expression of ELF5 mRNA CTD PMID:15171707 diuron decreases expression ISO RGD:1305859 6480464 Diuron results in decreased expression of ELF5 mRNA CTD PMID:21551480 lead diacetate decreases expression ISO RGD:1314144 6480464 lead acetate results in decreased expression of ELF5 mRNA CTD PMID:22609695 tert-butyl hydroperoxide increases expression ISO RGD:1314144 6480464 tert-Butylhydroperoxide results in increased expression of ELF5 mRNA CTD PMID:15003993
Gene Ontology Annotations
Biological Process cell proliferation TAS 2290271 PMID:9840936 PINC PMID:9840936 ectoderm development IEA Ensembl:ENSMUSP00000126941 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 mammary gland epithelial cell differentiation IEA Ensembl:ENSMUSP00000126941 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 transcription from RNA polymerase II promoter TAS 2290271 PMID:9840936 PINC PMID:9840936
1358830 MULTSCL21_H Multiple sclerosis susceptibility QTL 21 (human) Multiple sclerosis susceptibility 11 12852167 38852167 Human 2293388 PRSTS222_H Prostate tumor susceptibility QTL 222 (human) 3.02 Prostate tumor susceptibility 11 12937065 38937065 Human 1559250 SCL60_H Serum cholesterol level QTL 60 (human) 1.84 Lipid level total cholesterol 11 13680696 39680696 Human 2315778 GLUCO160_H Glucose level QTL 160 (human) 1.65 .003 Glucose level 11 13680696 39680696 Human 1576345 LVC1_H Left ventricular contractility QTL 1 (human) 3.93 Left ventricular contractility 11 16817071 70403343 Human 1559104 SCL15_H Serum cholesterol level QTL 15 (human) 2.6 .06 Lipid level hyperlipidemia susceptibility 11 17086204 79965640 Human 1559116 SCL24_H Serum cholesterol level QTL 24 (human) 2.11 .000009 Lipid level triglyceride 11 21640179 47640179 Human 2293464 PRSTS303_H Prostate tumor susceptibility QTL 303 (human) .015 Prostate tumor susceptibility 11 21640179 47640179 Human 2316031 GLUCO215_H Glucose level QTL 215 (human) .07 Glucose level 11 23023320 49023320 Human 2316050 GLUCO209_H Glucose level QTL 209 (human) .046 Glucose level 11 23023320 49023320 Human 2316340 GLUCO222_H Glucose level QTL 222 (human) .0013 Glucose level 11 27974426 53974426 Human 1559107 SCL32_H Serum cholesterol level QTL 32 (human) 3.27 Lipid level LDL cholesterol 11 28913978 70403233 Human 1559113 SCL31_H Serum cholesterol level QTL 31 (human) 3.72 Lipid level LDL cholesterol 11 28913978 70403233 Human 1643364 BW338_H Body weight QTL 338 (human) 2.21 Body fat amount percent body fat 11 30610207 56610207 Human 2315893 GLUCO189_H Glucose level QTL 189 (human) 2.25 Glucose level 11 30610207 56610207 Human
Gene Ontology Annotations
