Gene: Nelfa (negative elongation factor complex member A, Whsc2)
Mus musculus
Symbol:
Nelfa
Name:
negative elongation factor complex member A, Whsc2
Description:
ENCODES a protein that exhibits chromatin binding; INVOLVED IN negative regulation of transcription elongation from RNA polymerase II promoter; FOUND IN nucleus; NELF complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
mWHSC2; negative elongation factor A; Nelf-A; OTTMUSP00000030365; Whsc2; Whsc2h; Wolf-Hirschhorn syndrome candidate 2 homolog
Orthologs:
Homo sapiens : NELFA
(negative elongation factor complex member A)
HGNC
Rattus norvegicus : Nelfa
(negative elongation factor complex member A)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 5 33,898,179 - 33,936,258 - NCBI Mouse cM Map 5 - NCBI Mouse Celera Assembly 5 31,375,430 - 31,405,361 - NCBI Mouse Genome Assembly Build 37 5 34,240,828 - 34,278,907 - NCBI Mouse Genome Assembly Build 36.1 5 34,240,828 - 34,278,907 - NCBI Mouse Cytogenetic Map 5 B2 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of WHSC2 mRNA; more ... CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WHSC2 mRNA; more ... CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WHSC2 mRNA; more ... CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of WHSC2 mRNA; more ... CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1305556 6480464 2,4-dinitrotoluene affects the expression of WHSC2 mRNA; more ... CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1305556 6480464 2,6-dinitrotoluene affects the expression of WHSC2 mRNA; more ... CTD PMID:21346803 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of WHSC2 mRNA CTD PMID:21715664 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WHSC2 gene; more ... CTD PMID:20938992 dexamethasone increases expression ISO RGD:1313651 6480464 Dexamethasone results in increased expression of WHSC2 mRNA; more ... CTD PMID:16144937 dibutyl phthalate decreases expression ISO RGD:1305556 6480464 Dibutyl Phthalate results in decreased expression of WHSC2 mRNA; more ... CTD PMID:21266533 disodium selenite decreases expression ISO RGD:1313651 6480464 Sodium Selenite results in decreased expression of WHSC2 mRNA; more ... CTD PMID:18175754 elemental selenium multiple interactions ISO RGD:1313651 6480464 [Selenium co-treated with Vitamin E] results in increased expression of WHSC2 mRNA; more ... CTD PMID:19244175 elemental selenium increases expression ISO RGD:1313651 6480464 Selenium results in increased expression of WHSC2 mRNA; more ... CTD PMID:19244175 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WHSC2 gene; more ... CTD PMID:20938992 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WHSC2 gene; more ... CTD PMID:20938992 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of WHSC2 mRNA; more ... CTD PMID:21829687 methotrexate affects expression EXP 6480464 Methotrexate affects the expression of WHSC2 mRNA; more ... CTD PMID:18502557 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of WHSC2 mRNA; more ... CTD PMID:19270015 phenytoin decreases expression ISO RGD:1305556 6480464 Phenytoin results in decreased expression of WHSC2 mRNA; more ... CTD PMID:20345932 rotenone decreases expression ISO RGD:1305556 6480464 Rotenone results in decreased expression of WHSC2 mRNA; more ... CTD PMID:19013527 selenium atom multiple interactions ISO RGD:1313651 6480464 [Selenium co-treated with Vitamin E] results in increased expression of WHSC2 mRNA; more ... CTD PMID:19244175 selenium atom increases expression ISO RGD:1313651 6480464 Selenium results in increased expression of WHSC2 mRNA; more ... CTD PMID:19244175
Gene Ontology Annotations
Biological Process
negative regulation of transcription elongation from RNA polymerase II promoter IMP 2290270 MGI:MGI:5014448|PMID:21670248 MGI MGI:MGI:5014448 PMID:21670248 regulation of transcription, DNA-dependent IEA UniProtKB-KW:KW-0805 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
1301341 Many3_m mandible asymmetry 3 (mouse) Not determined 5 4368263 38368361 Mouse 1301806 Actd2_m activity-distance traveled 2 (mouse) Not determined 5 4685340 38685472 Mouse 1301146 Obq11_m obesity QTL 11 (mouse) Not determined 5 7111533 41111675 Mouse 4141207 Imrfq1_m immune response to Factor IX QTL 1 (mouse) Not determined 5 7424937 41425059 Mouse 4142377 Secia1_m small effect CIA locus 1 (mouse) Not determined 5 7474980 41475119 Mouse 4141920 Vmmt5_m vertebral morphology and mechanical traits 5 (mouse) Not determined 5 10281935 44282072 Mouse 1357808 Mgdr2_m muscle Gapd decay rate 2 (mouse) Not determined 5 10281935 44282072 Mouse 1300964 Hdlq22_m HDL QTL 22 (mouse) Not determined 5 15132687 49132904 Mouse 1301685 Estq2_m estradiol regulated response QTL 2 (mouse) Not determined 5 15779113 49779219 Mouse 1558858 Scpro7_m Stem cell proliferation 7 (mouse) Not determined 5 18957616 52957725 Mouse 1301355 Hipp2_m hippocampal weight 2 (mouse) Not determined 5 18957616 52957725 Mouse 1300719 Iba5_m induction of brown adipocytes 5 (mouse) Not determined 5 20920888 54921029 Mouse 1301264 Cocia6_m cocaine induced activation 6 (mouse) Not determined 5 20920888 54921029 Mouse 1301776 Skts3_m skin tumor susceptibility 3 (mouse) Not determined 5 21901191 55901299 Mouse 1357688 Mgdr1_m muscle Gapd decay rate 1 (mouse) Not determined 5 27449245 61449348 Mouse 1300701 Cd8ts1_m CD8 T cell subset 1 (mouse) Not determined 5 27449245 61449348 Mouse 1302076 Vmbic2_m ventral midbrain iron content 2 (mouse) Not determined 5 27449245 61449348 Mouse 1300760 Nobq1_m New Zealand obese QTL 1 (mouse) Not determined 5 29021463 63021569 Mouse 1301403 Alcp9_m alcohol preference locus 9 (mouse) Not determined 5 31258172 65258377 Mouse 1302061 Szv1_m seizure severity 1 (mouse) Not determined 5 31258172 65258377 Mouse 1301555 Alcp10_m alcohol preference locus 10 (mouse) Not determined 5 31258172 65258377 Mouse 4142228 Adip13_m adiposity 13 (mouse) Not determined 5 33722564 67722773 Mouse 1301693 Sle6_m systemic lupus erythematosus susceptibility 6 (mouse) Not determined 5 33817671 67817825 Mouse