PCDHGA7 (protocadherin gamma subfamily A, 7)

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Keyword

Gene: PCDHGA7 (protocadherin gamma subfamily A, 7) Homo sapiens

Symbol:

PCDHGA7

Name:

protocadherin gamma subfamily A, 7

Description:

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

OTTHUMP00000224535; PCDH-GAMMA-A7; protocadherin gamma-A7

Orthologs:

Mus musculus : Pcdhga7 (protocadherin gamma subfamily A, 7) MGI
Rattus norvegicus : Pcdhga7 (protocadherin gamma subfamily A, 7)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	141,039,144 - 141,169,210	+	NCBI
Human Genome Assembly HuRef	5	135,907,542 - 136,037,386	+	NCBI
Human Genome Assembly GRCh37	5	140,762,467 - 140,892,546	+	NCBI
Human Celera Assembly	5	136,839,290 - 136,969,282	+	NCBI
Human Genome Assembly Build 36	5	140,742,651 - 140,872,730	+	NCBI
Human Cytogenetic Map	5	q31		NCBI
Human Genome Assembly	5	140,742,650 - 140,745,371		NCBI