Gene: Thoc5 (THO complex 5)
Mus musculus
Symbol:
Thoc5
Name:
THO complex 5
Description:
ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN negative regulation of macrophage differentiation; primitive hemopoiesis; intronless viral mRNA export from host nucleus (ortholog); ASSOCIATED WITH abnormal bone marrow cell physiology; abnormal lymphopoiesis; anemia; ASSOCIATED WITH Anemia; Leukopenia; Breast Neoplasms (ortholog); FOUND IN intermediate filament cytoskeleton (ortholog); intracellular membrane-bounded organelle (ortholog); nucleus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; lead diacetate
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
1700060C24Rik; A430085L24Rik; Fmip; Fms interacting protein; fms-interacting protein; MGC49541; OTTMUSP00000005283; PK1.3; RP23-64E17.4; serum/glucocorticoid regulated kinase 2; Sgk2; THO complex subunit 5 homolog
Orthologs:
Homo sapiens : THOC5
(THO complex 5)
HGNC
Rattus norvegicus : Thoc5
(THO complex 5)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 4,895,343 - 4,928,865 + NCBI Mouse cM Map 11 + NCBI Mouse Celera Assembly 11 5,392,170 - 5,426,353 + NCBI Mouse Genome Assembly Build 37 11 4,795,346 - 4,828,868 + NCBI Mouse Genome Assembly Build 36.1 11 4,795,346 - 4,828,868 + NCBI Mouse Cytogenetic Map 11 A1 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THOC5 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THOC5 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of THOC5 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1304991 6480464 2,4-dinitrotoluene affects the expression of THOC5 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1304991 6480464 2,6-dinitrotoluene affects the expression of THOC5 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1349222 6480464 beta-methylcholine affects the expression of THOC5 mRNA CTD PMID:21179406 coumestrol increases expression ISO RGD:1349222 6480464 Coumestrol results in increased expression of THOC5 mRNA CTD PMID:19167446 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of THOC5 mRNA CTD PMID:20542052 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of THOC5 mRNA CTD PMID:19042947 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of THOC5 mRNA CTD PMID:17292431
Biological Process
cell differentiation IEA UniProtKB-KW:KW-0221 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 intronless viral mRNA export from host nucleus ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 monocyte differentiation ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 mRNA export from nucleus ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 mRNA processing IEA UniProtKB-KW:KW-0507 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 mRNA transport IEA UniProtKB-KW:KW-0509 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 negative regulation of macrophage differentiation IDA 2290270 MGI:MGI:1349551|PMID:10597251 MGI MGI:MGI:1349551 PMID:10597251 primitive hemopoiesis IMP 2290270 MGI:MGI:4943620|PMID:20051105 UniProtKB MGI:MGI:4943620 PMID:20051105 RNA splicing IEA UniProtKB-KW:KW-0508 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transport IEA UniProtKB-KW:KW-0813 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
cytoplasm IEA UniProtKB-KW:KW-0963 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 intermediate filament cytoskeleton ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 intracellular membrane-bounded organelle ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleus ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 THO complex ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 THO complex part of transcription export complex ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transcription export complex ISO UniProtKB:Q13769 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Molecular Function
protein binding IPI UniProtKB:P09581 2290270 MGI:MGI:1349551|PMID:10597251 MGI MGI:MGI:1349551 PMID:10597251 RNA binding IEA UniProtKB-KW:KW-0694 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
1301634 Eae6a_m susceptibility to experimental allergic encephalomyelitis 6a (mouse) Not determined 11 1146473 35146596 Mouse 1357842 Hipp5_m hippocampal weight 5 (mouse) Not determined 11 844334 34844436 Mouse 4141955 Hemq4_m hematocrit QTL 4 (mouse) Not determined 11 177055 34177235 Mouse 1558945 Orgwq8_m organ weight QTL 8 (mouse) Not determined 11 6178 34006316 Mouse 1301887 Nidd4n_m non-insulin-dependent diabetes mellitus 4 in NSY (mouse) Not determined 11 1 33598304 Mouse 4142184 Mcvq2_m mean corpuscular volume QTL 2 (mouse) Not determined 11 1 29218746 Mouse 4141419 Gluchos2_m glucose homeostasis QTL 2 (mouse) Not determined 11 1 29218746 Mouse 1300905 Scc6_m colon tumor susceptibility 6 (mouse) Not determined 11 1 29218746 Mouse 1301802 Bglq8_m body growth late QTL 8 (mouse) Not determined 11 1 25926377 Mouse 1558727 Manln10_m mandible length 10 (mouse) Not determined 11 1 25926377 Mouse 1301765 Skull15_m skull morphology 15 (mouse) Not determined 11 1 25926377 Mouse 1300661 Lmr6_m leishmaniasis resistance 6 (mouse) Not determined 11 1 25926377 Mouse 1300768 Tshp9_m tooth shape 9 (mouse) Not determined 11 1 25926377 Mouse 1357722 Vtbt11_m vertebral trabecular bone trait 11 (mouse) Not determined 11 1 23830490 Mouse 1357480 Igf1sl4_m IGF-1 serum levels 4 (mouse) Not determined 11 1 23830490 Mouse