Gene: CLCA2 (chloride channel accessory 2) Homo sapiens
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Symbol: CLCA2
Name: chloride channel accessory 2
Description: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACC; CaCC-3; CACC3; calcium-activated chloride channel family member 2; calcium-activated chloride channel protein 3; calcium-activated chloride channel regulator 2; calcium-activated chloride channel-2; chloride channel regulator 2; chloride channel, calcium activated, family member 2; CLCA family member 2, chloride channel regulator; CLCRG2; FLJ97885; hCaCC-3; hCLCA2; OTTHUMP00000011911
Orthologs:
Mus musculus (house mouse) : Clca2 (chloride channel accessory 2)  MGI
Rattus norvegicus (Norway rat) : Clca2 (chloride channel accessory 2)
Chinchilla lanigera (long-tailed chinchilla) : Clca2 (chloride channel accessory 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCA2 (chloride channel accessory 2)
Canis lupus familiaris (dog) : CLCA2 (chloride channel accessory 2)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38186,424,086 - 86,456,558 (+)NCBIGRCh38hg38GRCh38
GRCh37186,889,769 - 86,922,241 (+)NCBIGRCh37hg19GRCh37
Build 36186,662,413 - 86,694,829 (+)NCBINCBI36hg18NCBI36
Build 34186,601,845 - 86,634,259NCBI
Celera185,133,768 - 85,166,240 (+)NCBI
Cytogenetic Map1p22.3NCBImapview
HuRef185,000,753 - 85,032,874 (+)NCBI
CHM1_1187,004,629 - 87,037,098 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CLCA2
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
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RGD Object Information
RGD ID: 1312594
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2017-09-12
Status: ACTIVE