Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | activation of Rho GTPase activity | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | angiogenesis | | IEA | UniProtKB-KW:KW-0037 | 2290271 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | cell surface receptor signaling pathway | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | negative regulation of cell migration | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | negative regulation of protein kinase activity | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | peptidyl-tyrosine phosphorylation | | IDA | | 2290271 | PMID:12775584 | UniProtKB | PMID:12775584 | positive regulation of angiogenesis | | IMP | | 2290271 | PMID:20043122 | UniProtKB | PMID:20043122 | positive regulation of cell migration | | IMP | | 2290271 | PMID:20043122 | UniProtKB | PMID:20043122 | positive regulation of cell proliferation | | IMP | | 2290271 | PMID:20043122 | UniProtKB | PMID:20043122 | positive regulation of cell-matrix adhesion | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | positive regulation of stress fiber assembly | | ISS | UniProtKB:Q60750 | 2290271 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | protein autophosphorylation | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | regulation of Rac GTPase activity | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | substrate adhesion-dependent cell spreading | | IDA | | 2290271 | PMID:19118217 | UniProtKB | PMID:19118217 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
| Pathway Interaction Database | EPHA forward signaling (PID:200142) |
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
Molecular Pathway Annotations
|
| External Database Links | |
| KEGG Pathway | Axon guidance |
| Pathway Interaction Database | EPHA forward signaling (PID:200142) |
References - curated| 1. |
GOA_HUMAN data from the GO Consortium |
| 2. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated| PubMed | 10207129 |
| 10369740 | |
| 10502115 | |
| 10730216 | |
| 11128993 | |
| 11256076 | |
| 11519828 | |
| 12477932 | |
| 12775584 | |
| 12853948 | |
| 14968112 | |
| 15146197 | |
| 15761153 | |
| 15951569 | |
| 16344560 | |
| 16737551 | |
| 16862074 | |
| 16964243 | |
| 17980912 | |
| 18308734 | |
| 18566674 | |
| 18590698 | |
| 18593464 | |
| 18728013 | |
| 18802966 | |
| 18990944 | |
| 19011600 | |
| 19118217 | |
| 19277044 | |
| 19525919 | |
| 19913121 | |
| 19949912 | |
| 20043122 | |
| 20596523 | |
| 20628086 | |
| 21042754 | |
| 21460840 | |
| 21460841 | |
| 21503576 | |
| 21906983 | |
| 22261062 | |
| 22362770 | |
| 22688511 | |
| 22939624 | |
| 23030051 | |
| 2825356 | |
| 8755474 | |
| 9267020 | |
| 9530499 | |
| 9576626 |
RGD Disease Portals| EPHA1 has been annotated in the following RGD Disease Portals. |
|||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
Comparative Map Data| EPHA1 (Homo sapiens) |
|
||||||||||||||||||||||||||||||||||||||||
| Epha1 (Mus musculus) |
|
||||||||||||||||||||||||||||||||||||||||
| Epha1 (Rattus norvegicus) |
|
Position Markers| RH69086 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| RH102690 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| RH12060 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| ZYX_3067 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| D20S1007 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| G10664 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
| RH47177 |
|
QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_005232 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AA723562 | (Get FASTA) | Search GEO for Microarray Profiles |
| AA723620 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AA788809 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AACC02000107 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01034136 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01034137 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC092214 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF101171 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AI057542 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK290351 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK313263 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01018007 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AU131228 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC130291 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC144156 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CD653381 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH236959 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471198 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN289899 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN289901 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU826604 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU826605 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M18391 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z27409 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_005232 | ||||||||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||||||||
| Protein Acc Id: | NP_005223 | ||||||||||||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_005223 | (Get FASTA) |
| GenBank Protein | AAA36747 | (Get FASTA) |
| AAD43440 | (Get FASTA) | |
| AAI30292 | (Get FASTA) | |
| AAS07458 | (Get FASTA) | |
| ACF47640 | (Get FASTA) | |
| ACF47641 | (Get FASTA) | |
| BAF83040 | (Get FASTA) | |
| CAA81796 | (Get FASTA) | |
| EAL23789 | (Get FASTA) | |
| EAW51845 | (Get FASTA) | |
| EAW51846 | (Get FASTA) | |
| EAW51847 | (Get FASTA) | |
| P21709 | (Get FASTA) |
Promoters| RGD ID: | 6805169 | ||||||||||
| Promoter ID: | HG_KWN:60113 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour | ||||||||||
| Transcripts: | OTTHUMT00000342150, OTTHUMT00000342151, OTTHUMT00000342156 | ||||||||||
| Position: |
|
| RGD ID: | 6805638 | ||||||||||
| Promoter ID: | HG_KWN:60114 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour | ||||||||||
| Transcripts: | OTTHUMT00000342154, OTTHUMT00000342155 | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | EPHA1 | COSMIC |
| Ensembl Genes | ENSG00000146904 | ENTREZGENE |
| Ensembl Protein | ENSP00000275815 | ENTREZGENE |
| Ensembl Transcript | ENST00000275815 | ENTREZGENE |
| Entrez Gene | 2041 | ENTREZGENE |
| Gene3D-CATH | 20.260 | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| SAM_type | UniProtKB/Swiss-Prot | |
| Germonline | ENSG00000146904 | |
| HGNC ID | 3385 | ENTREZGENE |
| HomoloGene Group ID | 3835 | ENTREZGENE |
| HPRD ID | 01554 | ENTREZGENE |
| InterPro | Ephrin_rcpt_lig-bd | UniProtKB/Swiss-Prot |
| Fibronectin_type3 | UniProtKB/Swiss-Prot | |
| Galactose-bd-like | UniProtKB/Swiss-Prot | |
| Growth_fac_rcpt | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| SAM | UniProtKB/Swiss-Prot | |
| SAM/pointed | UniProtKB/Swiss-Prot | |
| SAM_type1 | UniProtKB/Swiss-Prot | |
| Ser-Thr/Tyr_kinase | UniProtKB/Swiss-Prot | |
| Tyr_kinase_AS | UniProtKB/Swiss-Prot | |
| Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Tyr_kinase_ephrin_rcpt | UniProtKB/Swiss-Prot | |
| Tyr_kinase_rcpt_V_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:2041 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 179610 | OMIM |
| Pfam | Ephrin_lbd | UniProtKB/Swiss-Prot |
| fn3 | UniProtKB/Swiss-Prot | |
| Pkinase_Tyr | UniProtKB/Swiss-Prot | |
| SAM_1 | UniProtKB/Swiss-Prot | |
| PharmGKB | PA27817 | PharmGKB |
| PIRSF | TyrPK_ephrin_receptor | UniProtKB/Swiss-Prot |
| PRINTS | TYRKINASE | UniProtKB/Swiss-Prot |
| PROSITE | EGF_2; UNKNOWN_1 | UniProtKB/Swiss-Prot |
| EPH_LBD | UniProtKB/Swiss-Prot | |
| FN3 | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot | |
| RECEPTOR_TYR_KIN_V_1 | UniProtKB/Swiss-Prot | |
| RECEPTOR_TYR_KIN_V_2 | UniProtKB/Swiss-Prot | |
| SAM_DOMAIN | UniProtKB/Swiss-Prot | |
| SMART | EPH_lbd | UniProtKB/Swiss-Prot |
| FN3 | UniProtKB/Swiss-Prot | |
| SAM | UniProtKB/Swiss-Prot | |
| TyrKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | FN_III-like | UniProtKB/Swiss-Prot |
| Gal_bind_like | UniProtKB/Swiss-Prot | |
| Grow_fac_recept | UniProtKB/Swiss-Prot | |
| Kinase_like | UniProtKB/Swiss-Prot | |
| SAM_homology | UniProtKB/Swiss-Prot | |
| UniGene | Hs.89839 | ENTREZGENE |
| UniProt | B5A967_HUMAN | UniProtKB/TrEMBL |
| EPHA1_HUMAN | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | EPHA1 | EPH receptor A1 | EPHA1 | EPH receptor A1 | Symbol and/or name change | 39860 | APPROVED |
| More on EPHA1 | |||
![]() |
Entrez Gene | ||
![]() |
Ensembl Gene | ||
|
|
||
![]() |
HGNC Report | ||
![]() |
NCBI Map Viewer | ||
![]() |
Vista | ||
![]() |
Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 1312265 |
| Created: | 2005-01-12 |
| Species: | Homo sapiens |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




