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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | actin polymerization-dependent cell motility | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | actin polymerization-dependent cell motility | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | B cell homeostasis | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | B cell homeostasis | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | B cell receptor signaling pathway | | ISO | RGD:1323803 | 1624291 | PMID:17875758 | RGD | PMID:17875758 | B cell receptor signaling pathway | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cortical actin cytoskeleton organization | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | cortical actin cytoskeleton organization | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | erythrocyte development | | ISO | RGD:1323803 | 1624291 | PMID:7643388 | RGD | PMID:7643388 | erythrocyte development | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | maintenance of cell polarity | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | maintenance of cell polarity | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | myeloid cell homeostasis | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | myeloid cell homeostasis | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of apoptotic process | | ISO | RGD:1323803 | 1624291 | PMID:17875758 | RGD | PMID:17875758 | negative regulation of apoptotic process | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of interleukin-17 production | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | negative regulation of interleukin-17 production | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of interleukin-6 production | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | negative regulation of interleukin-6 production | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of myosin-light-chain-phosphatase activity | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | negative regulation of myosin-light-chain-phosphatase activity | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | neutrophil chemotaxis | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | neutrophil chemotaxis | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of actin filament polymerization | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of actin filament polymerization | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of actin filament polymerization | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of actin filament polymerization | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | positive regulation of B cell differentiation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of B cell differentiation | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of B cell proliferation | | ISO | RGD:1323803 | 1624291 | PMID:17875758 | RGD | PMID:17875758 | positive regulation of B cell proliferation | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of CD4-positive, alpha-beta T cell differentiation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of CD4-positive, alpha-beta T cell differentiation | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of CD8-positive, alpha-beta T cell differentiation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of CD8-positive, alpha-beta T cell differentiation | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of cell adhesion mediated by integrin | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of cell adhesion mediated by integrin | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of erythrocyte differentiation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of erythrocyte differentiation | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of gamma-delta T cell differentiation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of gamma-delta T cell differentiation | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of lymphocyte differentiation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of neutrophil chemotaxis | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of neutrophil chemotaxis | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of phagocytosis, engulfment | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of phagocytosis, engulfment | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of phosphorylation | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | positive regulation of protein kinase activity | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | positive regulation of Rac GTPase activity | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | positive regulation of T cell proliferation | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | positive regulation of T cell proliferation | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein complex assembly | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | protein complex assembly | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | response to chemical stimulus | | ISO | RGD:1323803 | 1624291 | PMID:16417406 | RGD | PMID:16417406 | response to drug | | ISO | RGD:1323803 | 1624291 | PMID:17875758 | RGD | PMID:17875758 | response to drug | | IEA | Ensembl:ENSP00000293373 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | T cell homeostasis | | ISO | RGD:1619908 | 1624291 | MGI:MGI:3818191|PMID:19015308 | RGD | MGI:MGI:3818191 PMID:19015308 | T cell homeostasis | | IEA | Ensembl:ENSMUSP00000035400 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | 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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Regulation of actin cytoskeleton |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Regulation of actin cytoskeleton |
References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
RGD automated data pipeline |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
RGD Disease Portals| Nckap1l has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Nckap1l (Rattus norvegicus) |
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| NCKAP1L (Homo sapiens) |
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| Nckap1l (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001108119 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06052804 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06052805 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01052842 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01052843 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01052844 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01052845 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474035 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227373 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108119 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001101589 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001101589 | (Get FASTA) |
| GenBank Protein | EDL86781 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000036829 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000058936 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000065753 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 315348 | ENTREZGENE |
| HomoloGene Group ID | 3901 | ENTREZGENE |
| InterPro | Nck-associated_protein-1 | UniProtKB/TrEMBL |
| IPI | IPI00949071 | UniProtKB/TrEMBL |
| KEGG Report | rno:315348 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | Nckap1 | UniProtKB/TrEMBL |
| UniGene | Rn.149002 | ENTREZGENE |
| UniProt | D3Z8V4_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-04-30 | Nckap1l | NCK associated protein 1 like | Nckap1l_predicted | NCK associated protein 1 like (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2006-03-30 | Nckap1l_predicted | NCK associated protein 1 like (predicted) | Hem1_predicted | hematopoietic protein 1 (predicted) | Symbol and Name updated | 10779 | APPROVED |
| 2005-01-12 | Hem1_predicted | hematopoietic protein 1 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Nckap1l | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1312032 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




