Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of XPO4 mRNA | CTD | PMID:23019147 and PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Xpo4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of XPO4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of XPO4 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | XPO4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of XPO4 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of XPO4 mRNA | CTD | PMID:20106945 and PMID:21632981 | 2,4,6-tribromophenol | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of XPO4 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of XPO4 mRNA | CTD | PMID:21346803 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in increased expression of XPO4 protein | CTD | PMID:31675489 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of XPO4 mRNA | CTD | PMID:30071829 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of XPO4 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of XPO4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of XPO4 mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of XPO4 mRNA | CTD | PMID:27153756 | alpha-pinene | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of XPO4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of XPO4 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of XPO4 mRNA | CTD | PMID:30047161 | aristolochic acid A | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of XPO4 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | XPO4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of XPO4 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | XPO4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of XPO4 gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | Xpo4 (Mus musculus) | 6480464 | arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein] more ... | CTD | PMID:26354774 | arsenite(3-) | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to XPO4 mRNA] | CTD | PMID:32406909 | atrazine | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of XPO4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of XPO4 mRNA | CTD | PMID:20064835 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of XPO4 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of XPO4 protein | CTD | PMID:31675489 | bisphenol A | increases expression | ISO | Xpo4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of XPO4 mRNA | CTD | PMID:35598803 | butanal | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of XPO4 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XPO4 mRNA | CTD | PMID:35301059 | cadmium dichloride | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of XPO4 protein | CTD | PMID:26220685 | cadmium dichloride | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XPO4 mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | ISO | Xpo4 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of XPO4 mRNA | CTD | PMID:25620056 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of XPO4 mRNA | CTD | PMID:23125180 | chlorpyrifos | decreases expression | ISO | Xpo4 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of XPO4 mRNA | CTD | PMID:37019170 | cisplatin | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of XPO4 mRNA | CTD | PMID:27594783 | clotrimazole | decreases expression | EXP | | 6480464 | Clotrimazole results in decreased expression of XPO4 mRNA | CTD | PMID:30047161 | coumarin | increases phosphorylation | ISO | XPO4 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of XPO4 protein | CTD | PMID:35688186 | crocidolite asbestos | increases expression | ISO | Xpo4 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in increased expression of XPO4 mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of XPO4 mRNA | CTD | PMID:20106945 | decabromodiphenyl ether | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in increased expression of XPO4 protein | CTD | PMID:31675489 | dibutyl phthalate | decreases expression | ISO | Xpo4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of XPO4 mRNA | CTD | PMID:21266533 | doxorubicin | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of XPO4 mRNA | CTD | PMID:29803840 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of XPO4 mRNA | CTD | PMID:24136188 | formaldehyde | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of XPO4 mRNA | CTD | PMID:23649840 | hydrogen peroxide | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of XPO4 mRNA | CTD | PMID:18951874 | ivermectin | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of XPO4 protein | CTD | PMID:32959892 | leptomycin B | multiple interactions | ISO | Xpo4 (Mus musculus) | 6480464 | leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]] more ... | CTD | PMID:26354774 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of XPO4 mRNA | CTD | PMID:30047161 | methylmercury chloride | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of XPO4 mRNA | CTD | PMID:28001369 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of XPO4 gene | CTD | PMID:33148267 | nickel atom | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Nickel results in increased expression of XPO4 mRNA | CTD | PMID:25583101 | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of XPO4 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of XPO4 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of XPO4 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Xpo4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of XPO4 mRNA | CTD | PMID:17562736 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of XPO4 gene | CTD | PMID:33148267 | resveratrol | multiple interactions | ISO | XPO4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of XPO4 mRNA | CTD | PMID:23557933 | silicon dioxide | increases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of XPO4 mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of XPO4 protein | CTD | PMID:30528433 | sunitinib | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of XPO4 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of XPO4 mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of XPO4 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of XPO4 mRNA | CTD | PMID:25729387 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of XPO4 gene | CTD | PMID:27618143 | trichostatin A | affects expression | ISO | XPO4 (Homo sapiens) | 6480464 | trichostatin A affects the expression of XPO4 mRNA | CTD | PMID:28542535 | triclosan | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of XPO4 mRNA | CTD | PMID:30510588 | trimellitic anhydride | increases expression | ISO | Xpo4 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of XPO4 mRNA | CTD | PMID:19042947 | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of XPO4 mRNA | CTD | PMID:30589522 | triptonide | increases expression | ISO | Xpo4 (Mus musculus) | 6480464 | triptonide results in increased expression of XPO4 mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | ISO | Xpo4 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of XPO4 mRNA | CTD | PMID:19136453 and PMID:21427059 | valproic acid | decreases expression | ISO | XPO4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of XPO4 mRNA | CTD | PMID:23179753 and PMID:27188386 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of XPO4 mRNA | CTD | PMID:19015723 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of XPO4 mRNA | CTD | PMID:23034163 | |