Nepro (nucleolus and neural progenitor protein) - Rat Genome Database

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Gene: Nepro (nucleolus and neural progenitor protein) Rattus norvegicus
Analyze
Symbol: Nepro
Name: nucleolus and neural progenitor protein
RGD ID: 1311458
Description: Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to act upstream of or within negative regulation of neuron differentiation. Predicted to be located in nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC303948; hypothetical protein MGC27931; LOC303948; MGC95106; RGD1311458; similar to cDNA sequence BC027231; hypothetical protein MGC27931; uncharacterized protein C3orf17 homolog; uncharacterized protein LOC303948
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,464,263 - 69,476,429 (-)NCBIGRCr8
mRatBN7.21155,958,265 - 55,970,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,958,267 - 55,970,432 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,771,935 - 64,784,100 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,433,786 - 57,445,951 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,504,113 - 56,516,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,919,477 - 60,931,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,919,453 - 60,931,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01165,032,119 - 65,044,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,497,040 - 57,509,205 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,554,630 - 57,566,794 (-)NCBI
Celera1155,521,866 - 55,534,031 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
nucleolus  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19906856   PMID:26178919  


Genomics

Comparative Map Data
Nepro
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,464,263 - 69,476,429 (-)NCBIGRCr8
mRatBN7.21155,958,265 - 55,970,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,958,267 - 55,970,432 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,771,935 - 64,784,100 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,433,786 - 57,445,951 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,504,113 - 56,516,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,919,477 - 60,931,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,919,453 - 60,931,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01165,032,119 - 65,044,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,497,040 - 57,509,205 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,554,630 - 57,566,794 (-)NCBI
Celera1155,521,866 - 55,534,031 (-)NCBICelera
Cytogenetic Map11q21NCBI
NEPRO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383113,002,444 - 113,019,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3113,002,444 - 113,019,861 (-)EnsemblGRCh38hg38GRCh38
GRCh373112,721,291 - 112,738,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363114,203,981 - 114,221,245 (-)NCBINCBI36Build 36hg18NCBI36
Build 343114,206,457 - 114,221,203NCBI
Celera3111,129,629 - 111,146,889 (-)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3110,104,836 - 110,122,102 (-)NCBIHuRef
CHM1_13112,684,833 - 112,702,093 (-)NCBICHM1_1
T2T-CHM13v2.03115,723,401 - 115,740,627 (-)NCBIT2T-CHM13v2.0
Nepro
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,544,645 - 44,559,994 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,544,664 - 44,557,647 (+)EnsemblGRCm39 Ensembl
GRCm381644,724,301 - 44,738,856 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1644,724,301 - 44,737,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv371644,724,412 - 44,737,245 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361644,643,631 - 44,656,464 (+)NCBIMGSCv36mm8
Celera1645,084,903 - 45,097,735 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1629.04NCBI
Nepro
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542713,233,970 - 13,248,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542713,232,375 - 13,247,164 (-)NCBIChiLan1.0ChiLan1.0
NEPRO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22111,005,032 - 111,022,295 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13111,009,807 - 111,027,183 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03110,152,415 - 110,169,736 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13117,076,649 - 117,094,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3117,076,649 - 117,094,041 (-)Ensemblpanpan1.1panPan2
NEPRO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,392,962 - 17,406,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3317,393,154 - 17,406,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,495,837 - 17,509,832 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03317,636,958 - 17,650,956 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3317,636,674 - 17,650,864 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13317,441,302 - 17,455,110 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,488,757 - 17,502,761 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03318,038,410 - 18,052,222 (-)NCBIUU_Cfam_GSD_1.0
Nepro
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602136,866,719 - 136,881,289 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936536638,961 - 655,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936536641,085 - 655,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEPRO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13146,902,041 - 146,915,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113146,902,010 - 146,914,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213156,503,350 - 156,514,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEPRO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12267,817,433 - 67,833,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2267,817,386 - 67,832,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604198,645,396 - 98,663,067 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nepro
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473135,514,769 - 35,528,659 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473135,514,696 - 35,528,822 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nepro
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:32
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000018473
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 14 8 17 8 16 16 30 3
Low 1 39 43 33 2 33 8 11 58 19 11 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018473   ⟹   ENSRNOP00000018474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,958,267 - 55,970,432 (-)Ensembl
Rnor_6.0 Ensembl1160,919,453 - 60,931,794 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109171   ⟹   ENSRNOP00000076577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,958,267 - 55,968,372 (-)Ensembl
RefSeq Acc Id: NM_001009678   ⟹   NP_001009678
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,464,263 - 69,476,429 (-)NCBI
mRatBN7.21155,958,265 - 55,970,432 (-)NCBI
Rnor_6.01160,919,477 - 60,931,642 (-)NCBI
Rnor_5.01165,032,119 - 65,044,284 (-)NCBI
RGSC_v3.41157,497,040 - 57,509,205 (-)RGD
Celera1155,521,866 - 55,534,031 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88456 (Get FASTA)   NCBI Sequence Viewer  
  EDM11154 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018474
  ENSRNOP00000018474.5
  ENSRNOP00000076577.1
Reference Protein Sequences
RefSeq Acc Id: NP_001009678   ⟸   NM_001009678
- UniProtKB: Q5I0D2 (UniProtKB/TrEMBL),   A6IR01 (UniProtKB/TrEMBL),   A0A8I5XV66 (UniProtKB/TrEMBL),   F7F501 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018474   ⟸   ENSRNOT00000018473
RefSeq Acc Id: ENSRNOP00000076577   ⟸   ENSRNOT00000109171
Protein Domains
Nucleolus and neural progenitor protein-like N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5I0D2-F1-model_v2 AlphaFold Q5I0D2 1-566 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311458 AgrOrtholog
BioCyc Gene G2FUF-21355 BioCyc
Ensembl Genes ENSRNOG00000013721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018473 ENTREZGENE
  ENSRNOT00000018473.7 UniProtKB/TrEMBL
  ENSRNOT00000109171.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127273 IMAGE-MGC_LOAD
InterPro DUF4477 UniProtKB/TrEMBL
KEGG Report rno:303948 UniProtKB/TrEMBL
MGC_CLONE MGC:95106 IMAGE-MGC_LOAD
NCBI Gene 303948 ENTREZGENE
PANTHER NUCLEOLUS AND NEURAL PROGENITOR PROTEIN UniProtKB/TrEMBL
  NUCLEOLUS AND NEURAL PROGENITOR PROTEIN UniProtKB/TrEMBL
Pfam DUF4477 UniProtKB/TrEMBL
PhenoGen Nepro PhenoGen
RatGTEx ENSRNOG00000013721 RatGTEx
UniProt A0A8I5XV66 ENTREZGENE, UniProtKB/TrEMBL
  A6IR01 ENTREZGENE, UniProtKB/TrEMBL
  F7F501 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0D2 ENTREZGENE
UniProt Secondary Q5I0D2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-28 Nepro  nucleolus and neural progenitor protein  RGD1311458  similar to cDNA sequence BC027231; hypothetical protein MGC27931  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311458  similar to cDNA sequence BC027231; hypothetical protein MGC27931  RGD1311458_predicted  similar to cDNA sequence BC027231; hypothetical protein MGC27931 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311458_predicted  similar to cDNA sequence BC027231; hypothetical protein MGC27931 (predicted)  LOC303948_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303948_predicted  similar to cDNA sequence BC027231; hypothetical protein MGC27931 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL