Pgap6 (post-GPI attachment to proteins 6)

Gene: Pgap6 (post-GPI attachment to proteins 6) Rattus norvegicus

Analyze

Symbol:

Pgap6

Name:

post-GPI attachment to proteins 6

RGD ID:

1311395

Description:

Predicted to be located in plasma membrane. Orthologous to human PGAP6 (post-GPI attachment to proteins 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

M83; post-glycosylphosphatidylinositol attachment to proteins 6; post-GPI attachment to proteins factor 6; Tmem8; Tmem8a; transmembrane protein 8 (five membrane-spanning domains); transmembrane protein 8A; type I transmembrane protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PGAP6 (post-GPI attachment to proteins 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pgap6 (post-glycosylphosphatidylinositol attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pgap6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PGAP6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PGAP6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pgap6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PGAP6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PGAP6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pgap6 (post-GPI attachment to proteins 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PGAP6 (post-GPI attachment to proteins 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pgap6 (post-glycosylphosphatidylinositol attachment to proteins 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem8a (transmembrane protein 8A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG13654	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pgap6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,643,081 - 15,652,912 (+)	NCBI		GRCr8
mRatBN7.2	10	15,138,918 - 15,148,431 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	15,138,959 - 15,148,431 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,878,593 - 19,888,041 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,367,472 - 19,376,920 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,866,862 - 14,876,335 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	15,484,952 - 15,495,380 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,484,795 - 15,495,377 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	15,298,650 - 15,309,080 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,384,648 - 15,394,120 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,385,789 - 15,395,171 (+)	NCBI
Celera	10	14,806,937 - 14,816,409 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

genetic disease (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium atom (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

clothianidin (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

folic acid (ISO)

lamivudine (ISO)

menadione (ISO)

methamphetamine (EXP)

ozone (ISO)

paracetamol (EXP)

pirinixic acid (ISO)

rotenone (EXP,ISO)

SCH 23390 (EXP)

Soman (EXP)

temozolomide (ISO)

thimerosal (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17897319	PMID:23533145

Genomics

Comparative Map Data

Pgap6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,643,081 - 15,652,912 (+)	NCBI		GRCr8
mRatBN7.2	10	15,138,918 - 15,148,431 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	15,138,959 - 15,148,431 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,878,593 - 19,888,041 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,367,472 - 19,376,920 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,866,862 - 14,876,335 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	15,484,952 - 15,495,380 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,484,795 - 15,495,377 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	15,298,650 - 15,309,080 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,384,648 - 15,394,120 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,385,789 - 15,395,171 (+)	NCBI
Celera	10	14,806,937 - 14,816,409 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

PGAP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	370,788 - 386,979 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	370,788 - 387,113 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	420,788 - 431,978 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	360,777 - 371,951 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	361,860 - 371,908	NCBI
Celera	16	621,328 - 632,498 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	339,818 - 350,835 (-)	NCBI		HuRef
CHM1_1	16	420,861 - 458,154 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	366,436 - 382,868 (-)	NCBI		T2T-CHM13v2.0

Pgap6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	26,332,290 - 26,342,228 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	26,332,273 - 26,342,228 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	26,112,752 - 26,123,254 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	26,113,299 - 26,123,254 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	26,250,261 - 26,260,199 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,840,917 - 25,850,854 (+)	NCBI		MGSCv36	mm8
Celera	17	26,647,061 - 26,657,000 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	13.06	NCBI

Pgap6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955442	16,821,275 - 16,830,275 (+)	NCBI	ChiLan1.0	ChiLan1.0

PGAP6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	598,412 - 609,789 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	4,388,759 - 4,400,126 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	361,783 - 378,207 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	361,783 - 378,207 (-)	Ensembl	panpan1.1		panPan2

PGAP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	40,139,259 - 40,144,957 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	40,136,561 - 40,144,957 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,399,491 - 41,408,248 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,478,213 - 40,486,979 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	40,477,826 - 40,487,762 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	40,166,539 - 40,175,293 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	40,126,755 - 40,135,506 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,606,010 - 40,614,776 (+)	NCBI		UU_Cfam_GSD_1.0

Pgap6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,473,410 - 112,482,762 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936501	564,963 - 580,617 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PGAP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	41,318,889 - 41,330,273 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	41,318,569 - 41,330,430 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,097,604 - 41,109,203 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PGAP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	311,625 - 322,355 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	311,334 - 322,243 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,850,448 - 30,861,205 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pgap6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624913	1,210,631 - 1,219,111 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pgap6
43 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	104
Interacting mature miRNAs:	129
Transcripts:	ENSRNOT00000027609
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat

Markers in Region

AW490096

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	15,147,280 - 15,147,376 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	15,494,227 - 15,494,322	NCBI	Rnor6.0
Rnor_5.0	10	15,307,927 - 15,308,022	UniSTS	Rnor5.0
RGSC_v3.4	10	15,392,970 - 15,393,065	UniSTS	RGSC3.4
Celera	10	14,815,259 - 14,815,354	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3								7	29	10
Low		40	57	41	19	41	1	3	67	6	31	11	1
Below cutoff		3					7	8					7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010055170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027609 ⟹ ENSRNOP00000027609

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	15,138,959 - 15,148,431 (+)	Ensembl
Rnor_6.0 Ensembl	10	15,485,905 - 15,495,377 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079826 ⟹ ENSRNOP00000069297

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	15,138,959 - 15,148,431 (+)	Ensembl
Rnor_6.0 Ensembl	10	15,484,795 - 15,494,572 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110211 ⟹ ENSRNOP00000082896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	15,139,284 - 15,148,431 (+)	Ensembl

RefSeq Acc Id:

NM_001106991 ⟹ NP_001100461

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,643,440 - 15,652,912 (+)	NCBI
mRatBN7.2	10	15,138,959 - 15,148,431 (+)	NCBI
Rnor_6.0	10	15,485,905 - 15,495,377 (+)	NCBI
Rnor_5.0	10	15,298,650 - 15,309,080 (+)	NCBI
RGSC_v3.4	10	15,384,648 - 15,394,120 (+)	RGD
Celera	10	14,806,937 - 14,816,409 (+)	RGD

Sequence:

show sequence

GCGGCAGGTCCATCCGAGCCATGGGAGCTCCGGGCAGAGGCAGCGGCGGCGGCCGCAGAGGCGG
CAGGGGCTGCCCAGGCGGGGGCGAGCGGCGCGGGACTCGGGAGGGGTAGCACGGGCCAAGCGTG
GAGCCATGGGCCGGGTTGGGGCCGGGAGCACAGCGCGGGTGGCAGCAGCCGGGTCACTGCTGCT
ACTGCTGCTGCTCCTGGCTCGGCCTCCGCCTGCCGCCGCCCGCAACATCAAGGAGAGCGAGGCT
GGACTGGTGTCTGAGCACTTCTCACAGGCCCCACAGAAGCTGTCCTTCTATAGCTGGTATGGTA
GCACCCGGCTTTTCCACTTCCGTGTGCCCCCAGACACCGTGCTGCTTCGATGGCTGCTGCATGT
GTCCCAGGGAGGTCCGTCATGCGCCGACGTAGAGATCACAGTGCATTTCCGCTATGGCGCCCCT
CCTGTCATCAACCCGCTGGGCACCAGCTTCCCTGACGACACCTTGACCCATGCCTCCTTCCATA
TCAAGACACTGCTGAGCACCATGTTACTGGGCAACACCTCAGTCAACATCTCCCACCCAGCCCC
TGGGGACTGGTTCCTGGTGGCTCACCTCCCTCCCTCATCCCAGAAGATCCAGGTGAAGGGCTTT
GTTCCAACCTGTGCCTACATCTTCCAGCCTGATATGCTGGTAATGAGGGTGGTTGAAGTCTCCA
TCCTAGAGCCCGACATTCCCCTCCCACAGACGCTGCTCTCCCACCCCAGCTACCTCAAGATCTT
TGTCCCTGAATACACCCAGGAGCTTCGCTTGGAACTGCAGGGCTGTGTGTCCAGTGTGAGCCCC
GGCTGCCCAGTACGTCTCACAGCGGGGGTGACCACCCTGCCTAGAAACTTCCAGAGGGTATTGA
CTTGCACTGGCCTTGCTCCATTCTGCCATTTGCTGCTGTCCTCTCCGCCCTGGGGCCGGTGGTT
ACAAGTGACAGTGGAGAGCCTGGCTGAACCTCACGTGACAGTGGGTTTCACTGCTAAAGCTGCC
TTTACAGCGTGTAGGCCATGGAGTGTGACCTTCCATCATCTAATACAAAACAACCCAAACCAGA
CTTACGATACCTCTGCAGTCCAGCTGTCCCAAAGTGCTGCCCACTGGGACCTGGGCAGGAGTGG
CCGGAGTAGCAGGGTAGACGGTGGCCCCTTCTGTCTCCTGAACTATCCAGTCCTGAGGGAGGAC
ACAGATGTGGTGTCTGTACACTTCCAGCCCCTGAATGGGGCCTTCGTGCTGGTGCATTCAAACA
TGCCTTCTGTAATGCAGCTCCGTCTTGATACAGGCATGGACAGCGGGGGCTCCTTCATCATTGT
CCTGAGGGCTAACAAGTCAGAGGTCACAAATGGCACCTCGGTAGCAGCTTGTGTGAATGTTGCC
TCACCTTTCCTCAGCTTCAACGCTTCACTCAACTGCACCACAGCCTTCTTCCAGGGCTATCCCA
TGTTTCTGAGTGCCTCATCTCACATGGCCAACCTCATCATCCCCTATCCGGAGACAGACAACTG
GTACCTCTCCTTGCAGCTTGTGTGCCCTGAGAGTCCTGAGGATTGTGAACAGGCCGCGGTTCGC
GTGGAGACCGTCTTGTATCTGGTGCCCTGTTTGAATGACTGTGGGCCCTATGGCCAGTGTCTCC
TGCTCCGTAGATACGGCTATCTGTACGCAGGCTGCAGCTGCAAGGCAGGTTGGCGTGGGTGGAG
CTGCACGGACAACAGCACAGCCCAGACTGCAGCCCAGCAGAGGGCAGCAGCACTTCTGCTCACG
CTTAGCAACCTCATGTTCCTGGCCCCCATTGCTATATCCGTGCACCGCTCCTTCCTGGTTGAGG
CCTCTGTCTACTTTTACACTATGTTCTTCTCAACGTTCTACCACGCCTGTGACCAGCCTGGGGA
GGCTGTGTTGTGTATCCTCAGCTATGACACGCTGCAGTACTGCGACTTTCTGGGTTCTGGGGCA
TCCACCTGGGTGACCATTCTTTGCATGGCCCGTCTGAAGACAATCCTGAAACAGGTACTACTTG
TCCTCGGCCTACTGGTCATCGCTATGTCCTTGCAGATGGATCGCAGGGGCATCTGGAACCTGAT
GGGACCTTGTGTCTTTGCCTTTGTGATCATGGCTTTCATGTGGATATACCGCTGTGGGCACCGA
CGTCAGTGCTACCCTACCTCGTGGCAGCGCTGGGTCTTCTACCTCCTGCCTGGCATCTCCATGG
CTTTTGTGGGCATCGCCATGTACACTTCAATGATGACCAGCGACAACTACTACTACACCCACAG
CATTTGGCACATCCTACTGGCTGGCAGTGTGGCATTTCTTCTCCCTCCACGAGAAGAAAAGGCT
GGGTCCTGGGCCTGTTTGCAGAAGTTCCCCTGTCACTACCAGATCTGCAGGAATGATCGGGATG
AGTTGTACACAGTGACATGATAAGGCTAGCTCACGGACACCCGAGACTCTAATGACCTCTTCAG
CCAGGACAGGAATGAGAGAGGTGCCTGTCTAGCCCCAACCAGGTTTCCATCTGAATAAAACTGT
CCTGAGACCCTTGGCTTCTTTCTCCAGAGGAGAAGACCCTCTCCACCCATAAAATCTTTATGGC
CGTTGCCAGTCAGAGCTGCTTCCACCTGGAGATAGACCACAGGTGCCACGTGTGGGCAGAGCAC
TCTGTTATGGCTGGAGACACAGATAAGGGGTTCCCGTGGTCCCCTTCCTTTGGGAAGCTGTGAT
GTGAGAGCCACAAGCAAGGAAGGCTGAGTGCACAGAGACCACTGTCCATGACATCGTGTACCCT
TGAATGCCACCCTGCCTTGGCATGGGGATGCCCTGCTGCTGCAGTTGCTATGGCAGAGGCCAAG
GTCATCAGAGAGCTGATTAAGACCTGGGGTGCTGTGTGCTGTCCCTCCCTCATTCTCTGTTGGA
GTGGGGGATCCTGGAAAGATCCTGGGGTAGCAGGCTGCTCAGCTGTATGAGGTGTGGCTCCAGA
AGGCACACAATGCTATGCCAGTGTCCTTCTCACCCTAAGAGTCCTAGGCCCCAGTCTGGTGAGC
ATTCTCTTGTGCTGTCCTAGGCACTAGGTTGAGGCTAACCCCTACTGGATCAATCGAGGTTTGA
GGAGTGGGTTCTGGAGCCCTGGTCCAGTCTTTCTGGTTTCCTGGGATCACTGAGTTGGCAATGC
AGTGTGCTCTGTCTGTATGGTTCCCACTATGAGGCCCATCTGCTCTGAGTACTAGGATTACAGG
TGTAGGCCTCTGGGCTCCTTCCCAAGCTATTAACATCCTTTATTTGGCCACCAAAGCACACTTT
AGCCCCTGAAAGGGGAAACATGTATATATTGTTGGGGGGAGGTGGTAAAATGTTACTGTTCTAA
GATATGAAGGCATATTTTTATGTAATTGGTGAATTTAATATTCTACAATGATTTTTTCAAACC

hide sequence

RefSeq Acc Id:

XM_063268946 ⟹ XP_063125016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,643,081 - 15,652,024 (+)	NCBI

RefSeq Acc Id:

XM_063268947 ⟹ XP_063125017

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,644,237 - 15,652,024 (+)	NCBI

RefSeq Acc Id:

XR_010055170

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,643,406 - 15,650,103 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100461	(Get FASTA)	NCBI Sequence Viewer
	XP_063125016	(Get FASTA)	NCBI Sequence Viewer
	XP_063125017	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03993	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027609
	ENSRNOP00000027609.4
	ENSRNOP00000069297.2
	ENSRNOP00000082896.1

RefSeq Acc Id:	NP_001100461 ⟸ NM_001106991
- Peptide Label:	precursor
- UniProtKB:	D3ZKI8 (UniProtKB/TrEMBL), A6HD88 (UniProtKB/TrEMBL), A0A0G2JV00 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRVGAGSTARVAAAGSLLLLLLLLARPPPAAARNIKESEAGLVSEHFSQAPQKLSFYSWYGST RLFHFRVPPDTVLLRWLLHVSQGGPSCADVEITVHFRYGAPPVINPLGTSFPDDTLTHASFHIK TLLSTMLLGNTSVNISHPAPGDWFLVAHLPPSSQKIQVKGFVPTCAYIFQPDMLVMRVVEVSIL EPDIPLPQTLLSHPSYLKIFVPEYTQELRLELQGCVSSVSPGCPVRLTAGVTTLPRNFQRVLTC TGLAPFCHLLLSSPPWGRWLQVTVESLAEPHVTVGFTAKAAFTACRPWSVTFHHLIQNNPNQTY DTSAVQLSQSAAHWDLGRSGRSSRVDGGPFCLLNYPVLREDTDVVSVHFQPLNGAFVLVHSNMP SVMQLRLDTGMDSGGSFIIVLRANKSEVTNGTSVAACVNVASPFLSFNASLNCTTAFFQGYPMF LSASSHMANLIIPYPETDNWYLSLQLVCPESPEDCEQAAVRVETVLYLVPCLNDCGPYGQCLLL RRYGYLYAGCSCKAGWRGWSCTDNSTAQTAAQQRAAALLLTLSNLMFLAPIAISVHRSFLVEAS VYFYTMFFSTFYHACDQPGEAVLCILSYDTLQYCDFLGSGASTWVTILCMARLKTILKQVLLVL GLLVIAMSLQMDRRGIWNLMGPCVFAFVIMAFMWIYRCGHRRQCYPTSWQRWVFYLLPGISMAF VGIAMYTSMMTSDNYYYTHSIWHILLAGSVAFLLPPREEKAGSWACLQKFPCHYQICRNDRDEL YTVT hide sequence

RefSeq Acc Id:

ENSRNOP00000069297 ⟸ ENSRNOT00000079826

RefSeq Acc Id:

ENSRNOP00000027609 ⟸ ENSRNOT00000027609

RefSeq Acc Id:

ENSRNOP00000082896 ⟸ ENSRNOT00000110211

RefSeq Acc Id:	XP_063125016 ⟸ XM_063268946
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063125017 ⟸ XM_063268947
- Peptide Label:	isoform X2

Protein Domains

EGF-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKI8-F1-model_v2	AlphaFold	D3ZKI8	1-772	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697071

Promoter ID:

EPDNEW_R7595

Type:

initiation region

Name:

Tmem8a_1

Description:

transmembrane protein 8A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	15,485,916 - 15,485,976	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311395	AgrOrtholog
BioCyc Gene	G2FUF-25729	BioCyc
Ensembl Genes	ENSRNOG00000020374	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027609	ENTREZGENE
	ENSRNOT00000027609.6	UniProtKB/TrEMBL
	ENSRNOT00000079826.2	UniProtKB/TrEMBL
	ENSRNOT00000110211.1	UniProtKB/TrEMBL
InterPro	DUF3522	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
KEGG Report	rno:303004	UniProtKB/TrEMBL
NCBI Gene	303004	ENTREZGENE
PANTHER	POST-GPI ATTACHMENT TO PROTEINS FACTOR 6	UniProtKB/TrEMBL
	PTHR14319	UniProtKB/TrEMBL
Pfam	DUF3522	UniProtKB/TrEMBL
PhenoGen	Pgap6	PhenoGen
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020374	RatGTEx
UniProt	A0A0G2JV00	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZVT8_RAT	UniProtKB/TrEMBL
	A6HD88	ENTREZGENE, UniProtKB/TrEMBL
	D3ZKI8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-03-22	Pgap6	post-GPI attachment to proteins 6	Pgap6	post-glycosylphosphatidylinositol attachment to proteins 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-09-30	Pgap6	post-glycosylphosphatidylinositol attachment to proteins 6	Tmem8a	transmembrane protein 8A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-25	Tmem8a	transmembrane protein 8A	Tmem8	transmembrane protein 8 (five membrane-spanning domains)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Tmem8	transmembrane protein 8 (five membrane-spanning domains)	Tmem8_predicted	transmembrane protein 8 (five membrane-spanning domains) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Tmem8_predicted	transmembrane protein 8 (five membrane-spanning domains) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar