Gene: Alg9 (alpha-1,2-mannosyltransferase)
Rattus norvegicus
Symbol:
Alg9
Name:
alpha-1,2-mannosyltransferase
Description:
ENCODES a protein that exhibits transferase activity, transferring glycosyl groups (inferred); INVOLVED IN GPI anchor biosynthetic process (inferred); PARTICIPATES IN N-linked glycan biosynthetic pathway; ASSOCIATED WITH Congenital disorder of glycosylation type 1L (ortholog); FOUND IN intrinsic to endoplasmic reticulum membrane (inferred); INTERACTS WITH 17alpha-ethynylestradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 4,4'-diaminodiphenylmethane (ortholog)
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Alg9_predicted; alpha-1,2-mannosyltransferase ALG9; asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase); asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase); asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase) ; asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase) (predicted); asparagine-linked glycosylation 9 protein; asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog; asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae); Dibd1; Dibd1_predicted; disrupted in bipolar affective disorder 1; disrupted in bipolar affective disorder 1 (predicted); LOC367083
Orthologs:
Homo sapiens : ALG9
(ALG9, alpha-1,2-mannosyltransferase)
HGNC
Alg9
(asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase))
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 8 q23 NCBI RGSC Genome Assembly v5.0 8 53,799,792 - 53,862,451 + NCBI RGSC Genome Assembly v3.4 8 54,131,722 - 54,194,200 + NCBI Rat Celera Assembly 8 50,667,014 - 50,729,187 + NCBI Genome Assembly 3.1 8 54,149,950 - 54,213,133 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1322641 6480464 Ethinyl Estradiol results in increased expression of ALG9 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1322641 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALG9 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1322641 6480464 Ethinyl Estradiol affects the expression of ALG9 mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1322641 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALG9 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1322641 6480464 Tetrachlorodibenzodioxin affects the expression of ALG9 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1322641 6480464 Tetrachlorodibenzodioxin results in increased expression of ALG9 mRNA CTD PMID:17942748 4,4'-diaminodiphenylmethane increases expression ISO RGD:1322641 6480464 4,4'-diaminodiphenylmethane results in increased expression of ALG9 mRNA CTD PMID:18648102 benzo[a]pyrene multiple interactions ISO RGD:1322641 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ALG9 mRNA CTD PMID:21715664 elemental selenium multiple interactions ISO RGD:1342764 6480464 [Selenium co-treated with Vitamin E] results in increased expression of ALG9 mRNA CTD PMID:19244175 hydrogen peroxide multiple interactions ISO RGD:1342764 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ALG9 protein CTD PMID:18951874 paracetamol affects expression ISO RGD:1322641 6480464 Acetaminophen affects the expression of ALG9 mRNA CTD PMID:17562736 phenobarbital increases expression ISO RGD:1322641 6480464 Phenobarbital results in increased expression of ALG9 mRNA CTD PMID:19270015 resveratrol decreases expression ISO RGD:1342764 6480464 resveratrol results in decreased expression of ALG9 mRNA CTD PMID:19371625 selenium atom multiple interactions ISO RGD:1342764 6480464 [Selenium co-treated with Vitamin E] results in increased expression of ALG9 mRNA CTD PMID:19244175 tamoxifen affects expression ISO RGD:1322641 6480464 Tamoxifen affects the expression of ALG9 mRNA CTD PMID:17555576 theophylline multiple interactions ISO RGD:1342764 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ALG9 protein CTD PMID:18951874 trans-resveratrol decreases expression ISO RGD:1342764 6480464 resveratrol results in decreased expression of ALG9 mRNA CTD PMID:19371625
Biological Process biological_process ND 1598407 01/2007: no relevant rat data RGD GPI anchor biosynthetic process IEA InterPro:IPR005599 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Cellular Component cellular_component ND 1598407 01/2007: no relevant rat data RGD intrinsic to endoplasmic reticulum membrane IEA InterPro:IPR005599 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Molecular Function molecular_function ND 1598407 01/2007: no relevant rat data RGD transferase activity, transferring glycosyl groups IEA UniProtKB-KW:KW-0328 1600115 GO_REF:0000038 UniProtKB GO_REF:0000038
71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 Glucose level postprandial 8 3039822 61462321 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 Brain/spinal cord inflammation demyelination 8 8294860 115338082 Rat 1598824 Memor4 Memory QTL 4 2.5 Memory navigation-spatial 8 9581132 56397678 Rat 61353 Bp35 Blood pressure QTL 35 Blood pressure 8 9581132 103685771 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 .005 White blood cell count 8 10116155 55116155 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 Joint/bone inflammation adjuvant induced 8 10116155 55116155 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 .00036 Spike wave discharge measurement frequency 8 16442230 61442230 Rat 631271 Cati1 Cataract Ihara QTL 1 .001 Cataract susceptibility 8 16468237 61468237 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 Renal function urine albumin level 8 19815642 98451660 Rat 631842 Inf1 Infertility severity QTL 1 4.1 .001 Seminal vesicle mass 8 26358063 71358063 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 .0003 Lipid level triglyceride 8 28414004 58991068 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 Kidney mass 8 28414004 103684785 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 Blood pressure post sympathetic nervous system block 8 28414004 103684785 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 Cardiac mass 8 28414004 103684785 Rat 2303572 Insul13 Insulin level QTL 13 2 Insulin level 8 29077622 74077622 Rat 2303564 Gluco43 Glucose level QTL 43 3 Glucose level fasting 8 29077622 74077622 Rat 1300146 Rf17 Renal function QTL 17 2.9 Renal function salt-loaded renal blood flow 8 29559446 74559446 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 Cardiac mass 8 29559446 103672447 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 Renal function urine albumin level 8 30878636 74178909 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5 0 Neurodegradation motoneuron cell number 8 31508524 98947320 Rat 1331744 Bp217 Blood pressure QTL 217 3.398 Blood pressure systolic 8 32203394 61853629 Rat 1359033 Bp273 Blood pressure QTL 273 Blood pressure response to intrathecal cytisine 8 32203394 64762616 Rat 2313046 Bss78 Bone structure and strength QTL 78 3.5 .0001 Bone strength 8 32203394 86628010 Rat 2313057 Bss76 Bone structure and strength QTL 76 3 .0001 Bone structure 8 32203394 86628010 Rat 2313067 Bss77 Bone structure and strength QTL 77 3.1 .0001 Bone structure 8 32203394 86628010 Rat 2313088 Bss75 Bone structure and strength QTL 75 3.1 .0001 Bone structure 8 32203394 86628010 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 Renal function urine abumin level 8 32203394 98986263 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 .0001 Renal function urine protein level 8 32203394 98986263 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 .0001 Renal histology kidney lesion grade 8 32203499 98986085 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 .001 Renal function urine albumin level 8 32203499 98986085 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 Lipid level serum cholesterol 8 32203499 110106272 Rat 1298065 Scl16 Serum cholesterol level QTL 16 3.8 Lipid level cholesterol 8 33897608 78897608 Rat 1582222 Epfw2 Epididymal fat weight QTL 2 3.2 .0005 Epididymal fat weight 8 34808657 79808657 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 .0004 Insulin level fasting 8 38003289 103665018 Rat 61358 Bp39 Blood pressure QTL 39 2 Blood pressure 8 38902937 83902937 Rat 737824 Hcar10 Hepatocarcinoma resistance QTL 10 2.9 Liver tumor resistance nodule number 8 43313902 87122960 Rat 1358906 Bp253 Blood pressure QTL 253 4 .0004 Blood pressure post sympathetic nervous system block 8 43313902 98451660 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 .0001 Bone mineral density distal femur volumetric BMD by pQCT 8 43561064 129041809 Rat 1331769 Rf39 Renal function QTL 39 3.871 Renal function urine volume 8 44484215 103672447 Rat 1298079 Activ2 Activity QTL 2 9.5 .000001 Activity level novel environment 8 44484215 129041809 Rat 631216 Stl9 Serum triglyceride level QTL 9 4.71 .0001 Lipid level triglyceride 8 44484347 74178405 Rat 70161 Bp62 Blood pressure QTL 62 2.9 .001 Blood pressure salt-loaded systolic 8 45291674 94514282 Rat 2313086 Bss60 Bone structure and strength QTL 60 4.1 .0001 Bone structure 8 53049279 86628010 Rat 4889938 Bss89 Bone structure and strength QTL 89 3.8 Bone structure 8 53049279 86628010 Rat 5684973 Bss100 Bone structure and strength QTL 100 4.7 Bone structure tibial area 8 53049279 86628010 Rat 2303570 Gluco48 Glucose level QTL 48 2 Glucose level post-restraint 8 53621297 98621297 Rat
Gene-Chemical Interaction Annotations
