Abo2 (histo-blood group ABO system transferase 2) - Rat Genome Database

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Gene: Abo2 (histo-blood group ABO system transferase 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abo2
Name: histo-blood group ABO system transferase 2
RGD ID: 1311152
Description: Predicted to enable glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase); PARTICIPATES IN lacto-series glycosphingolipid metabolic pathway; INTERACTS WITH bisphenol A; methamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a transferase; Abo; ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase); b blood group galactosyltransferase; b transferase; blood group A glycosyltransferase 2; cis-AB transferase 2; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase; histo-blood group ABO system transferase 2-like; histo-blood group B transferase; LOC100911704; NAGAT 2; putative blood group A transferase T2; transferase B, alpha 1-3-galactosyltransferase)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,409,553 - 30,426,477 (+)NCBIGRCr8
mRatBN7.2310,011,475 - 10,028,397 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,002,834 - 10,028,396 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,073,279 - 13,089,583 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,658,678 - 21,674,982 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,913,976 - 19,930,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,386,434 - 5,402,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,386,434 - 5,402,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,737,036 - 10,753,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,589,306 - 5,596,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,309,990 - 5,597,149 (+)NCBI
Celera34,828,494 - 4,829,181 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IBA)
membrane  (IEA)
vesicle  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Banales JM, etal., Am J Pathol. 2008 Dec;173(6):1637-46. Epub 2008 Nov 6.
2. Lack of association between asthma and ABO blood group. Bijanzadeh M, etal., Lung. 2009 Nov-Dec;187(6):389-92. Epub 2009 Sep 22.
3. ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan. Chen YL, etal., Clin Exp Allergy. 2005 Jul;35(7):926-32.
4. ABO blood group and susceptibility to severe acute respiratory syndrome. Cheng Y, etal., JAMA. 2005 Mar 23;293(12):1450-1.
5. [The distribution of ABO system blood groups in patients with unilocular echinococcosis]. Chobanov RE and Salekhov AA, Med Parazitol (Mosk). 1990 Mar-Apr;(2):18-20.
6. [Correlations of the antigenic specificity of human blood with the levels of antihemagglutinins to influenza viruses]. Fedorova GI, etal., Vopr Virusol. 1983 Jan-Feb;28(1):54-7.
7. Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. Flentke GR, etal., Dev Dyn. 2004 Apr;229(4):886-98.
8. Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. Fullmer JM, etal., J Comp Neurol. 2007 Mar 1;501(1):70-82.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of rat colon carcinoma cells. Marionneau S, etal., Glycobiology. 2002 Dec;12(12):851-6.
12. Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection. Olson FJ, etal., J Biol Chem 2002 Apr 26;277(17):15044-52.
13. ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. Pandey M, etal., BMJ. 1995 Jun 24;310(6995):1639.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case-Control Study. Risch HA, etal., J Natl Cancer Inst. 2010 Feb 24.
18. Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways. Taylor SG, etal., Glycobiology 2003 May;13(5):327-37.
19. Cloning of a rat gene encoding the histo-blood group B enzyme: rats have more than one Abo gene. Turcot AL, etal., Glycobiology. 2003 Dec;13(12):919-28. Epub 2003 Jun 10.
20. [Genetic markers of the ABO blood system in pulmonary sarcoidosis patients of different ethnic origin]. Volkova KI and Godes IE, Klin Med (Mosk). 1996;74(8):44-6.
21. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Wolpin BM, etal., Cancer Res. 2010 Feb 1;70(3):1015-23. Epub 2010 Jan 26.

Genomics

Variants

.
Variants in Abo2
253 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:56
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000061276
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

Markers in Region
RH132268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,162,172 - 10,162,384 (+)MAPPERmRatBN7.2
mRatBN7.2310,028,107 - 10,028,319 (-)MAPPERmRatBN7.2
Rnor_6.035,386,026 - 5,386,237NCBIRnor6.0
Rnor_6.034,374,754 - 4,374,965NCBIRnor6.0
Rnor_5.039,729,996 - 9,730,207UniSTSRnor5.0
Rnor_5.0310,737,095 - 10,737,306UniSTSRnor5.0
RGSC_v3.435,596,564 - 5,596,775UniSTSRGSC3.4
RGSC_v3.435,730,628 - 5,730,839UniSTSRGSC3.4
Celera34,960,705 - 4,960,916UniSTS
Celera34,829,378 - 4,829,589UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system reproductive system
High
Medium
Low 1
Below cutoff 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000061276   ⟹   ENSRNOP00000057988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,011,475 - 10,028,393 (+)Ensembl
Rnor_6.0 Ensembl35,386,434 - 5,402,666 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099183   ⟹   ENSRNOP00000091204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,002,834 - 10,028,396 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106649   ⟹   ENSRNOP00000079782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,021,572 - 10,028,396 (+)Ensembl
RefSeq Acc Id: NM_001271298   ⟹   NP_001258227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,409,553 - 30,426,477 (+)NCBI
mRatBN7.2310,011,475 - 10,028,397 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001258227 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057988
  ENSRNOP00000057988.3
  ENSRNOP00000079782.1
  ENSRNOP00000091204.1
RefSeq Acc Id: ENSRNOP00000057988   ⟸   ENSRNOT00000061276
RefSeq Acc Id: ENSRNOP00000079782   ⟸   ENSRNOT00000106649
RefSeq Acc Id: ENSRNOP00000091204   ⟸   ENSRNOT00000099183
RefSeq Acc Id: NP_001258227   ⟸   NM_001271298
- UniProtKB: D4A7T1 (UniProtKB/TrEMBL),   A6JTH9 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RE11-F1-model_v2 AlphaFold M0RE11 1-327 view protein structure
AF-D4A7T1-F1-model_v2 AlphaFold D4A7T1 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311152 AgrOrtholog
BioCyc Gene G2FUF-50337 BioCyc
Ensembl Genes ENSRNOG00000045801 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061276 ENTREZGENE
  ENSRNOT00000061276.5 UniProtKB/TrEMBL
  ENSRNOT00000099183.1 UniProtKB/TrEMBL
  ENSRNOT00000106649.1 UniProtKB/TrEMBL
InterPro Glyco_trans_6 UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
NCBI Gene 296504 ENTREZGENE
PANTHER Glyco_trans_6 UniProtKB/TrEMBL
  HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE UniProtKB/TrEMBL
Pfam Glyco_transf_6 UniProtKB/TrEMBL
PhenoGen Abo2 PhenoGen
RatGTEx ENSRNOG00000045801 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A8I5ZPA3_RAT UniProtKB/TrEMBL
  A0A8I6ADA3_RAT UniProtKB/TrEMBL
  A6JTH9 ENTREZGENE, UniProtKB/TrEMBL
  D4A7T1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Abo2  histo-blood group ABO system transferase 2  LOC100911704  histo-blood group ABO system transferase 2-like  Data merged from RGD:6491244 737654 PROVISIONAL
2012-07-05 LOC100911704  histo-blood group ABO system transferase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-04-21 Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)  Abo_predicted  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Abo_predicted  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (predicted)  LOC687450  similar to N-acetylgalactosaminyltransferase A blood group-like enzyme  Data merged from RGD:1585355 1643240 APPROVED
2006-11-19 LOC687450  similar to N-acetylgalactosaminyltransferase A blood group-like enzyme      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Abo_predicted  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (predicted)      Symbol and Name status set to approved 70820 APPROVED